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    paaG putative ring 1,2-epoxyphenylacetyl-CoA isomerase (oxepin-CoA forming) [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946263, updated on 3-Dec-2024

    Summary

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    Official Symbol
    paaG
    Official Full Name
    putative ring 1,2-epoxyphenylacetyl-CoA isomerase (oxepin-CoA forming)
    Primary source
    ECOCYC:G6715
    Locus tag
    b1394
    See related
    ASAP:ABE-0004661
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1391; ydbT
    Summary
    paaG mutants accumulate ring-1,2-dihydroxy-1,2-dihydrophenylacetyl lactone. [More information is available at EcoGene: EG13741]. PaaG is a putative enoyl-CoA hydratase/isomerase involved in phenylacetate catabolism . [More information is available at EcoCyc: G6715].
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    Genomic context

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    Sequence:
    NC_000913.3 (1458264..1459052)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene phenylacetate degradation protein Neighboring gene phenylacetyl-CoA 1,2-epoxidase, reductase subunit Neighboring gene putative 2,3-dehydroadipyl-CoA hydratase Neighboring gene 3-hydroxyadipyl-CoA dehydrogenase Neighboring gene phenylacetyl-CoA thioesterase Neighboring gene beta-ketoadipyl-CoA thiolase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protein-protein interactions in the β-oxidation part of the phenylacetate utilization pathway: crystal structure of the PaaF-PaaG hydratase-isomerase complex. Grishin AM, et al. J Biol Chem, 2012 Nov 2. PMID 22961985, Free PMC Article
    2. New FadB homologous enzymes and their use in enhanced biosynthesis of medium-chain-length polyhydroxyalkanoates in FadB mutant Escherichia coli. Park SJ, et al. Biotechnol Bioeng, 2004 Jun 20. PMID 15137080
    3. Functional genomics by NMR spectroscopy. Phenylacetate catabolism in Escherichia coli. Ismail W, et al. Eur J Biochem, 2003 Jul. PMID 12846838
    4. A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map. Aiba H, et al. DNA Res, 1996 Dec 31. PMID 9097039
    5. Large-scale identification of protein-protein interaction of Escherichia coli K-12. Arifuzzaman M, et al. Genome Res, 2006 May. PMID 16606699, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that the PaaFG complex has a four-layered structure composed of homotrimeric discs of PaaF and PaaG.
      Title: Protein-protein interactions in the β-oxidation part of the phenylacetate utilization pathway: crystal structure of the PaaF-PaaG hydratase-isomerase complex.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phenylacetate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phenylacetate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phenylacetate catabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative ring 1,2-epoxyphenylacetyl-CoA isomerase (oxepin-CoA forming)
    NP_415912.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1458264..1459052
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415912.1 putative ring 1,2-epoxyphenylacetyl-CoA isomerase (oxepin-CoA forming) [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415912.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376TG89
      Conserved Domains (1) summary
      PRK08140
      Location:1 → 262
      PRK08140; enoyl-CoA hydratase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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