caiB gamma-butyrobetainyl-CoA:carnitine CoA transferase [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: caiB
Official Full Name: gamma-butyrobetainyl-CoA:carnitine CoA transferase
Primary source: ECOCYC:EG11559
Locus tag: b0038
See related: ASAP:ABE-0000136
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK0039; yaaN
Summary: Uses gamma-butyrobetainyl-CoA as co-factor. [More information is available at EcoGene: EG11559]. The crystal structure of CaiB has been solved and shows that two monomers form an interlaced dimer . [More information is available at EcoCyc: EG11559].
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NC_000913.3 Genomic Context describing neighboring genes

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N-terminus verified by Edman degradation on complete protein
Title: Crotonobetaine reductase from Escherichia coli consists of two proteins.
crystal structure
Title: Crystal structure of Escherichia coli crotonobetainyl-CoA: carnitine CoA-transferase (CaiB) and its complexes with CoA and carnitinyl-CoA.
The binding of coenzyme A to CaiB induces a domain movement that closes the active site of the protein and can play an important role in coupling substrate binding to initiation of the catalytic reaction.
Title: Crystal structure of CaiB, a type-III CoA transferase in carnitine metabolism.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables CoA-transferase activity	IEA Inferred from Electronic Annotation more info
enables L-carnitine CoA-transferase activity	EXP Inferred from Experiment more info	PubMed
enables L-carnitine CoA-transferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity, transferring sulphur-containing groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within carnitine catabolic process	EXP Inferred from Experiment more info	PubMed
involved_in carnitine metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

NP_414580.1

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