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    mcrC Type IV methyl-directed restriction enzyme EcoKMcrBC subunit [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948880, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mcrC
    Official Full Name
    Type IV methyl-directed restriction enzyme EcoKMcrBC subunit
    Primary source
    ECOCYC:EG10575
    Locus tag
    b4345
    See related
    ASAP:ABE-0014248
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4335
    Summary
    McrC modulates the specificity of McrB and stimulates hydrolysis of GTP by McrB 30-fold . [More information is available at EcoCyc: EG10575].
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    Genomic context

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    Sequence:
    NC_000913.3 (4576912..4577958, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative uncharacterized protein YjiT Neighboring gene pseudo Neighboring gene 5-methylcytosine-specific restriction enzyme subunit McrB;McrBS Neighboring gene nucleoid-associated protein SymE Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The recognition of methylated DNA by the GTP-dependent restriction endonuclease McrBC resides in the N-terminal domain of McrB. Gast FU, et al. Biol Chem, 1997 Sep. PMID 9348106
    2. Characterization of the mcrBC region of Escherichia coli K-12 wild-type and mutant strains. Krüger T, et al. Gene, 1992 May 1. PMID 1316864
    3. Organization and function of the mcrBC genes of Escherichia coli K-12. Raleigh EA. Mol Microbiol, 1992 May. PMID 1316984
    4. McrBC: a multisubunit GTP-dependent restriction endonuclease. Sutherland E, et al. J Mol Biol, 1992 May 20. PMID 1317461
    5. Identification of a second polypeptide required for McrB restriction of 5-methylcytosine-containing DNA in Escherichia coli K12. Ross TK, et al. Mol Gen Genet, 1989 Apr. PMID 2664457

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables type IV site-specific deoxyribonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables type IV site-specific deoxyribonuclease activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA restriction-modification system IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA restriction-modification system NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of endonuclease complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Type IV methyl-directed restriction enzyme EcoKMcrBC subunit

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4576912..4577958 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418765.1 Type IV methyl-directed restriction enzyme EcoKMcrBC subunit [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418765.1

      Status: PROVISIONAL

      Conserved Domains (1) summary
      PRK09736
      Location:1 → 348
      PRK09736; 5-methylcytosine-specific restriction enzyme subunit McrC; Provisional
    Nucleotide Protein
    Heading Accession and Version

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