dxs 1-deoxy-D-xylulose-5-phosphate synthase [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: dxs
Official Full Name: 1-deoxy-D-xylulose-5-phosphate synthase
Primary source: ECOCYC:G6237
Locus tag: b0420
See related: ASAP:ABE-0001461
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK0414; yajP
Summary: 1-deoxyxylulose-5-phosphate synthase (Dxs) catalyzes the first, rate-limiting step in the methylerythritol phosphate pathway of isoprenoid biosynthesis, as well as feeding into the pyridoxal 5-phosphate and thiamine biosynthesis pathways. [More information is available at EcoCyc: G6237].
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NC_000913.3 Genomic Context describing neighboring genes

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H49 and H299 of dxs are critical for the closed, predecarboxylation state providing the first direct link between catalysis and conformational dynamics.
Title: Active Site Histidines Link Conformational Dynamics with Catalysis on Anti-Infective Target 1-Deoxy-d-xylulose 5-Phosphate Synthase.
N-terminus verified by Edman degradation on mature peptide
Title: Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables 1-deoxy-D-xylulose-5-phosphate synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-deoxy-D-xylulose-5-phosphate synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-deoxy-D-xylulose-5-phosphate synthase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables thiamine pyrophosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables thiamine pyrophosphate binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transketolase or transaldolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 1-deoxy-D-xylulose 5-phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in glyceraldehyde-3-phosphate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in isoprenoid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within isoprenoid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pyridoxine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in terpenoid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in thiamine biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within thiamine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ubiquinone biosynthetic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

NP_414954.1

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