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    feaB phenylacetaldehyde dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945933, updated on 17-Dec-2024

    Summary

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    Official Symbol
    feaB
    Official Full Name
    phenylacetaldehyde dehydrogenase
    Primary source
    ECOCYC:G7961
    Locus tag
    b1385
    See related
    ASAP:ABE-0004637
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1382; padA; ydbG
    Summary
    Phenylacetaldehyde dehydrogenase is a dimer in solution . [More information is available at EcoCyc: G7961].
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    Genomic context

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    Sequence:
    NC_000913.3 (1447519..1449018)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF1318 domain-containing protein YdbL Neighboring gene DNA-binding transcriptional activator FeaR Neighboring gene copper-containing amine oxidase Neighboring gene fused 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase and oxepin-CoA hydrolase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. 2-Phenylethylamine catabolism by Escherichia coli K12. Parrott S, et al. J Gen Microbiol, 1987 Feb. PMID 3309152
    2. Chemotaxis of Escherichia coli to norepinephrine (NE) requires conversion of NE to 3,4-dihydroxymandelic acid. Pasupuleti S, et al. J Bacteriol, 2014 Dec. PMID 25182492, Free PMC Article
    3. Finely tuned regulation of the aromatic amine degradation pathway in Escherichia coli. Zeng J, et al. J Bacteriol, 2013 Nov. PMID 24013633, Free PMC Article
    4. Escherichia coli NsrR regulates a pathway for the oxidation of 3-nitrotyramine to 4-hydroxy-3-nitrophenylacetate. Rankin LD, et al. J Bacteriol, 2008 Sep. PMID 18658270, Free PMC Article
    5. Characterization of E. coli tetrameric aldehyde dehydrogenases with atypical properties compared to other aldehyde dehydrogenases. Rodríguez-Zavala JS, et al. Protein Sci, 2006 Jun. PMID 16731973, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Only strains that produce TynA and FeaB converting norepinephrine to 3,4-dihydroxymandelic acid xhibited chemotaxis toward norepinephrine and 3,4-dihydroxymandelic acid is sensed by the serine chemoreceptor Tsr.
      Title: Chemotaxis of Escherichia coli to norepinephrine (NE) requires conversion of NE to 3,4-dihydroxymandelic acid.
    2. Using genetic, biochemical and computational approaches, authors show that the FeaR binding site is a TGNCA-N8-AAA motif that occurs in 2 copies in the tynA and feaB promoters.
      Title: Finely tuned regulation of the aromatic amine degradation pathway in Escherichia coli.
    3. N-terminus verified by Edman degradation on complete protein
      Title: Molecular characterization of PadA, a phenylacetaldehyde dehydrogenase from Escherichia coli.
    4. phenylacetaldehyde dehydrogenases (PAD) used both NAD+ and NADP+ but with a clear preference for NAD
      Title: Characterization of E. coli tetrameric aldehyde dehydrogenases with atypical properties compared to other aldehyde dehydrogenases.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 4-hydroxyphenylacetaldehyde dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aldehyde dehydrogenase [NAD(P)+] activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phenylacetaldehyde dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phenylacetaldehyde dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phenylacetaldehyde dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within 4-nitrophenol catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in L-phenylalanine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within NAD biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within phenylethylamine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phenylacetaldehyde dehydrogenase
    NP_415903.4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1447519..1449018
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415903.4 phenylacetaldehyde dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415903.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1X3J1L1, A0A1X3JHW4
      Conserved Domains (1) summary
      cd07113
      Location:21 → 499
      ALDH_PADH_NahF; Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like
    Nucleotide Protein
    Heading Accession and Version

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