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    ryhB [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 2847761, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ryhB
    Primary source
    ECOCYC:G0-8872
    Locus tag
    b4451
    See related
    ASAP:ABE-0047271
    Gene type
    ncRNA
    RNA name
    other
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3426; IS176; psrA18; sraI
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    Genomic context

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    Sequence:
    NC_000913.3 (3580922..3581016, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene quercetin 2,3-dioxygenase Neighboring gene putative oxidoreductase YhhX Neighboring gene N-acetyltransferase YhhY Neighboring gene putative endonuclease YhhZ Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Metabolic and physiological perturbations of Escherichia coli W3100 by bacterial small RNA RyhB. Lyu Y, et al. Biochimie, 2019 Jul. PMID 31002843
    2. Regulation by iron: RNA rules the rust. Kadner RJ. J Bacteriol, 2005 Oct. PMID 16199555, Free PMC Article
    3. RyhB in Avian Pathogenic Escherichia coli Regulates the Expression of Virulence-Related Genes and Contributes to Meningitis Development in a Mouse Model. Meng X, et al. Int J Mol Sci, 2022 Dec 8. PMID 36555174, Free PMC Article
    4. RyhB small RNA modulates the free intracellular iron pool and is essential for normal growth during iron limitation in Escherichia coli. Jacques JF, et al. Mol Microbiol, 2006 Nov. PMID 17078818
    5. Small RNAs controlling iron metabolism. Massé E, et al. Curr Opin Microbiol, 2007 Apr. PMID 17383226

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RyhB in Avian Pathogenic Escherichia coli Regulates the Expression of Virulence-Related Genes and Contributes to Meningitis Development in a Mouse Model.
      Title: RyhB in Avian Pathogenic Escherichia coli Regulates the Expression of Virulence-Related Genes and Contributes to Meningitis Development in a Mouse Model.
    2. The authors demonstrated RyhB has substantial effects on E. coli cell physiology as well as central carbon metabolism.
      Title: Metabolic and physiological perturbations of Escherichia coli W3100 by bacterial small RNA RyhB.
    3. High iron supply inhibits the synthesis of the genotoxin colibactin by pathogenic Escherichia coli through a non-canonical Fur/RyhB-mediated pathway.
      Title: High iron supply inhibits the synthesis of the genotoxin colibactin by pathogenic Escherichia coli through a non-canonical Fur/RyhB-mediated pathway.
    4. PNPase and RNase PH facilitate the stability and regulatory function of the sRNAs RyhB, CyaR, and MicA during exponential growth.
      Title: The Phosphorolytic Exoribonucleases Polynucleotide Phosphorylase and RNase PH Stabilize sRNAs and Facilitate Regulation of Their mRNA Targets.
    5. findings show how an sRNA, RyhB, and a transcription factor, IscR, regulate expression of an essential gene, erpA, in E. coli
      Title: A Regulatory Circuit Composed of a Transcription Factor, IscR, and a Regulatory RNA, RyhB, Controls Fe-S Cluster Delivery.
    6. The authors report that O2 availability affects the gene expression programs of two Escherichia coli master regulators that function in iron homeostasis: the transcription factor Fur and the small RNA regulator RyhB.
      Title: Impact of Anaerobiosis on Expression of the Iron-Responsive Fur and RyhB Regulons.
    7. In a murine model of urinary tract infection (UTI), deletion of fur alone did not attenuate virulence, whereas a DeltaryhB mutant and a Deltafur DeltaryhB double mutant showed significantly reduced bladder colonization.
      Title: The small RNA RyhB contributes to siderophore production and virulence of uropathogenic Escherichia coli.
    8. Here the small RNA ryhB, which regulates the metabolism of iron in Escherichia coli, was constitutively expressed in engineered E. coli DALA.
      Title: Constitutive expression of RyhB regulates the heme biosynthesis pathway and increases the 5-aminolevulinic acid accumulation in Escherichia coli.
    9. Data show that small RNA (sRNA) RyhB controls iron metabolism and directly pairs with the 5'UTR region of msrB at two distinct sites, but msrA expression is not sensitive to changes in iron availability.
      Title: The sRNA RyhB regulates the synthesis of the Escherichia coli methionine sulfoxide reductase MsrB but not MsrA.
    10. RyhB had a comprehensive influence on glucose central metabolism.
      Title: Small RNA RyhB as a potential tool used for metabolic engineering in Escherichia coli.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

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