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    astD aldehyde dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946260, updated on 3-Dec-2024

    Summary

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    Official Symbol
    astD
    Official Full Name
    aldehyde dehydrogenase
    Primary source
    ECOCYC:G6942
    Locus tag
    b1746
    See related
    ASAP:ABE-0005820
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1744; ydjU
    Summary
    AstD is also a decanal or succinic semialdehyde dehydrogenase. [More information is available at EcoGene: EG13997]. A high-throughput screen of purified proteins showed that AstD is an aldehyde dehydrogenase with broad substrate specificity. [More information is available at EcoCyc: G6942].
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    Genomic context

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    Sequence:
    NC_000913.3 (1828256..1829734, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene ATP-independent periplasmic chaperone Neighboring gene succinylglutamate desuccinylase Neighboring gene N-succinylarginine dihydrolase Neighboring gene arginine N-succinyltransferase Neighboring gene succinylornithine transaminase Neighboring gene exodeoxyribonuclease III

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Indole can act as an extracellular signal in Escherichia coli. Wang D, et al. J Bacteriol, 2001 Jul. PMID 11418561, Free PMC Article
    2. Escherichia coli genes regulated by cell-to-cell signaling. Baca-DeLancey RR, et al. Proc Natl Acad Sci U S A, 1999 Apr 13. PMID 10200310, Free PMC Article
    3. ArgR-independent induction and ArgR-dependent superinduction of the astCADBE operon in Escherichia coli. Kiupakis AK, et al. J Bacteriol, 2002 Jun. PMID 12003934, Free PMC Article
    4. Arginine catabolism and the arginine succinyltransferase pathway in Escherichia coli. Schneider BL, et al. J Bacteriol, 1998 Aug. PMID 9696779, Free PMC Article
    5. Temporal gene-expression in Escherichia coli K-12 biofilms. Domka J, et al. Environ Microbiol, 2007 Feb. PMID 17222132

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables aldehyde dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aldehyde dehydrogenase [NAD(P)+] activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables succinate-semialdehyde dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables succinylglutamate-semialdehyde dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in arginine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in arginine catabolic process to glutamate IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in arginine catabolic process to succinate IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in arginine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    aldehyde dehydrogenase
    NP_416260.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1828256..1829734 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416260.1 aldehyde dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416260.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376S9Z1, A0A8S7EGI2
      Conserved Domains (1) summary
      PRK09457
      Location:1 → 487
      astD; succinylglutamic semialdehyde dehydrogenase; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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