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    ssrA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945053, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ssrA
    Primary source
    ECOCYC:EG30100
    Locus tag
    b2621
    See related
    ASAP:ABE-0008624
    Gene type
    ncRNA
    RNA name
    other
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2617; sipB
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    Genomic context

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    Sequence:
    NC_000913.3 (2755593..2755955)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative component of the Rsx system Neighboring gene ribosome association toxin RatA Neighboring gene SsrA-binding protein Neighboring gene integrase IntA Neighboring gene uncharacterized protein YfjH

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The tmRNA website. Williams KP. Nucleic Acids Res, 1999 Jan 1. PMID 9847167, Free PMC Article
    2. tmRDB (tmRNA database). Zwieb C, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520048, Free PMC Article
    3. Comparative sequence analysis of tmRNA. Zwieb C, et al. Nucleic Acids Res, 1999 May 15. PMID 10219077, Free PMC Article
    4. Traffic at the tmRNA gene. Williams KP. J Bacteriol, 2003 Feb. PMID 12533482, Free PMC Article
    5. Trans-translation and protein synthesis inhibitors. Vioque A, et al. FEMS Microbiol Lett, 2003 Jan 21. PMID 12583891

    See all (185) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Authors conclude that SsrA and SmpB are important for persister survival.
      Title: Trans-translation mediates tolerance to multiple antibiotics and stresses in Escherichia coli.
    2. tmRNA (ssrA) regulates the synthesis of ArfA.
      Title: tmRNA regulates synthesis of the ArfA ribosome rescue factor.
    3. THe efficient translatability of the conserved alanine resume codon is a crucial for ssrA function.
      Title: Functional significance of an evolutionarily conserved alanine (GCA) resume codon in tmRNA in Escherichia coli.
    4. Strikingly, tmRNA-mediated SsrA peptide tagging of two proteins, ribosomal protein S7 and LacI, was dramatically increased in DeltarluD cells.
      Title: Deletion of the RluD pseudouridine synthase promotes SsrA peptide tagging of ribosomal protein S7.
    5. Data identify two components of the trans-translation machinery, transfer-messenger RNA (tmRNA) and SmpB, that are responsible for the short half-life of RNase R in exponential phase cells.
      Title: A novel mechanism for ribonuclease regulation: transfer-messenger RNA (tmRNA) and its associated protein SmpB regulate the stability of RNase R.
    6. The authors show that Hha induces excision of prophages, CP4-57 and DLP12, by inducing excision genes and by reducing SsrA synthesis.
      Title: Control and benefits of CP4-57 prophage excision in Escherichia coli biofilms.
    7. ClpXP, together with SspB, is uniquely adapted for degradation of SsrA-tagged proteins and is responsible for the major part of their degradation in vivo
      Title: Turnover of endogenous SsrA-tagged proteins mediated by ATP-dependent proteases in Escherichia coli.
    8. Ribosome, tmRNA and SmpB are found to be in equimolar amounts in the tmRNA-ribosome complexes stopped at different positions of the coding part of the tmRNA.
      Title: One SmpB molecule accompanies tmRNA during its passage through the ribosomes.
    9. Overproduction of tmRNA rescues the temperature-sensitive phenotype of a peptidyl-tRNA hydrolase mutant Escherichia coli strain.
      Title: A physiological connection between tmRNA and peptidyl-tRNA hydrolase functions in Escherichia coli.
    10. a cluster of conserved residues in SmpB binding to SsrA RNA might represent a core contact surface for recognition of SsrA RNA
      Title: Role of conserved surface amino acids in binding of SmpB protein to SsrA RNA.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

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