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    hokB toxin HokB [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 2847727, updated on 3-Dec-2024

    Summary

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    Official Symbol
    hokB
    Official Full Name
    toxin HokB
    Primary source
    ECOCYC:G0-9610
    Locus tag
    b4428
    See related
    ASAP:ABE-0047283
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1412; ydcB
    Summary
    Sequence analysis indicates that the hokB gene is a homologue of the hok (host killing) gene which is responsible for mediating plasmid stabilization by post-segregational killing (PSK) in plasmid R1. hok encodes a stable mRNA whose translation is inhibited by a less stable mRNA encoded by sok. [More information is available at EcoCyc: G0-9610].
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    Genomic context

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    Sequence:
    NC_000913.3 (1491922..1492071, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene protein YdcA Neighboring gene protein YncP Neighboring gene putative regulatory protein MokB Neighboring gene ncRNA Neighboring gene methyl-accepting chemotaxis protein Trg

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Persistence-Inducing Toxin HokB Forms Dynamic Pores That Cause ATP Leakage. Wilmaerts D, et al. mBio, 2018 Aug 14. PMID 30108166, Free PMC Article
    2. Postoperative adrenal cortical insufficiency; occurrence in patients previously treated with cortisone. SALASSA RM, et al. J Am Med Assoc, 1953 Aug 15. PMID 13061310
    3. Biochemical determinants of ObgE-mediated persistence. Verstraeten N, et al. Mol Microbiol, 2019 Nov. PMID 31498933
    4. Obg and Membrane Depolarization Are Part of a Microbial Bet-Hedging Strategy that Leads to Antibiotic Tolerance. Verstraeten N, et al. Mol Cell, 2015 Jul 2. PMID 26051177
    5. Nucleotide sequence of the cybB gene encoding cytochrome b561 in Escherichia coli K12. Nakamura H, et al. Mol Gen Genet, 1988 Apr. PMID 2836696

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Gene Ontology Provided by EcoCyc

    Process Evidence Code Pubs
    involved_in dormancy process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within dormancy process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    toxin HokB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1491922..1492071 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_025301.1 toxin HokB [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for YP_025301.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A286MK15, A0A6N9S5I5
      Conserved Domains (1) summary
      PRK09738
      Location:1 → 49
      PRK09738; small toxic polypeptide; Provisional
    Nucleotide Protein
    Heading Accession and Version

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