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    morA motility regulator [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 881084, updated on 24-Aug-2024

    Summary

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    Gene symbol
    morA
    Gene description
    motility regulator
    Locus tag
    PA4601
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (5156368..5160615)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene resistance-nodulation-cell division (RND) multidrug efflux membrane fusion protein MexC Neighboring gene transcriptional regulator NfxB Neighboring gene serine hydroxymethyltransferase Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Global Regulator MorA Affects Virulence-Associated Protease Secretion in Pseudomonas aeruginosa PAO1. Ravichandran A, et al. PLoS One, 2015. PMID 25894344, Free PMC Article
    2. MorA defines a new class of regulators affecting flagellar development and biofilm formation in diverse Pseudomonas species. Choy WK, et al. J Bacteriol, 2004 Nov. PMID 15489433, Free PMC Article
    3. Formation and dimerization of the phosphodiesterase active site of the Pseudomonas aeruginosa MorA, a bi-functional c-di-GMP regulator. Phippen CW, et al. FEBS Lett, 2014 Dec 20. PMID 25447517
    4. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
    5. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MorA, a global regulator with GGDEF and EAL domains that was previously reported to affect virulence factors, negatively regulates protease secretion via the type II secretion system (T2SS) in P. aeruginosa PAO1.
      Title: Global Regulator MorA Affects Virulence-Associated Protease Secretion in Pseudomonas aeruginosa PAO1.
    2. dimerization of the phosphodiesterase active site of the Pseudomonas aeruginosa MorA
      Title: Formation and dimerization of the phosphodiesterase active site of the Pseudomonas aeruginosa MorA, a bi-functional c-di-GMP regulator.
    3. novel membrane-localized regulator that impairs biofilm formation
      Title: MorA defines a new class of regulators affecting flagellar development and biofilm formation in diverse Pseudomonas species.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    motility regulator
    NP_253291.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      5156368..5160615
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_253291.1 motility regulator [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_253291.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      Q9HVI8
      Conserved Domains (4) summary
      PRK13560
      Location:518 → 974
      PRK13560; hypothetical protein; Provisional
      COG5000
      Location:269 → 374
      NtrY; Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]
      PRK10060
      Location:838 → 1406
      PRK10060; cyclic di-GMP phosphodiesterase
      pfam08447
      Location:618 → 699
      PAS_3; PAS fold
    Nucleotide Protein
    Heading Accession and Version

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