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    Atg2b autophagy related 2B [ Mus musculus (house mouse) ]

    Gene ID: 76559, updated on 9-Dec-2024

    Summary

    Official Symbol
    Atg2bprovided by MGI
    Official Full Name
    autophagy related 2Bprovided by MGI
    Primary source
    MGI:MGI:1923809
    See related
    Ensembl:ENSMUSG00000041341 AllianceGenome:MGI:1923809
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA4067; 2410024A21Rik; C030004M05Rik; C630028L02Rik
    Summary
    Predicted to enable phosphatidylinositol-3-phosphate binding activity and protein-membrane adaptor activity. Predicted to be involved in autophagy of mitochondrion and macroautophagy. Predicted to be located in endoplasmic reticulum membrane; lipid droplet; and phagophore assembly site membrane. Predicted to be active in phagophore and phagophore assembly site. Orthologous to human ATG2B (autophagy related 2B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 6.2), testis adult (RPKM 5.5) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Atg2b in Genome Data Viewer
    Location:
    12 E; 12 55.82 cM
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (105579798..105651554, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (105613539..105685297, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_33182 Neighboring gene bradykinin receptor, beta 2 Neighboring gene STARR-positive B cell enhancer ABC_E4041 Neighboring gene bradykinin receptor, beta 1 Neighboring gene STARR-seq mESC enhancer starr_33186 Neighboring gene STARR-seq mESC enhancer starr_33187 Neighboring gene STARR-positive B cell enhancer ABC_E5352 Neighboring gene GSK3B interacting protein Neighboring gene adenylate kinase 7 Neighboring gene STARR-seq mESC enhancer starr_33192 Neighboring gene STARR-seq mESC enhancer starr_33193

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA4067

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lipid transfer activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol-3-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-membrane adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glycophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intermembrane lipid transfer IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in pexophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in piecemeal microautophagy of the nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in reticulophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in phagophore IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in phagophore assembly site IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in phagophore assembly site membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    autophagy-related protein 2 homolog B
    Names
    ATG2 autophagy related 2 homolog B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001403515.1NP_001390444.1  autophagy-related protein 2 homolog B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC068459, AC158526
    2. NM_029654.5NP_083930.5  autophagy-related protein 2 homolog B isoform 1

      See identical proteins and their annotated locations for NP_083930.5

      Status: VALIDATED

      Source sequence(s)
      AC068459, AC158526
      Consensus CDS
      CCDS36550.1
      UniProtKB/Swiss-Prot
      A0PJL7, Q80XK6, Q8BIQ4, Q8BIV0, Q8R1H5, Q9CWK6
      Related
      ENSMUSP00000037441.8, ENSMUST00000041055.9
      Conserved Domains (3) summary
      pfam09333
      Location:19772071
      ATG_C; Autophagy-related protein C terminal domain
      pfam12624
      Location:11105
      Chorein_N; N-terminal region of Chorein or VPS13
      pfam13329
      Location:12391359
      ATG2_CAD; Autophagy-related protein 2 CAD motif

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      105579798..105651554 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157656.1XP_036013549.1  autophagy-related protein 2 homolog B isoform X3

      UniProtKB/TrEMBL
      A0A1Y7VNP1
      Conserved Domains (1) summary
      pfam09333
      Location:9161010
      ATG_C; Autophagy-related protein C terminal domain
    2. XM_006516361.3XP_006516424.1  autophagy-related protein 2 homolog B isoform X2

      UniProtKB/TrEMBL
      A0A1Y7VNP1
      Related
      ENSMUSP00000152527.2, ENSMUST00000221015.2
      Conserved Domains (1) summary
      pfam09333
      Location:9171011
      ATG_C; Autophagy-related protein C terminal domain