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    Ttf1 transcription termination factor, RNA polymerase I [ Mus musculus (house mouse) ]

    Gene ID: 22130, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ttf1provided by MGI
    Official Full Name
    transcription termination factor, RNA polymerase Iprovided by MGI
    Primary source
    MGI:MGI:105044
    See related
    Ensembl:ENSMUSG00000026803 AllianceGenome:MGI:105044
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TTF-1; TTF-I
    Summary
    Enables DNA binding activity and chromatin binding activity. Involved in termination of RNA polymerase I transcription. Acts upstream of or within chromatin remodeling and transcription initiation at RNA polymerase I promoter. Located in nucleolus and nucleoplasm. Is expressed in several structures, including central nervous system; early conceptus; and genitourinary system. Orthologous to human TTF1 (transcription termination factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Note: Ttf1 (GeneID 22130) and Nkx2-1 (GeneID 21869) loci share the Ttf1 symbol/alias in common. Ttf1 is a widely used alternative name for thyroid transcription factor 1 (Nkx2-1) conflicting with the official symbol for transcription termination factor, RNA polymerase I (Ttf1). [13 Feb 2013]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 5.0), bladder adult (RPKM 3.8) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ttf1 in Genome Data Viewer
    Location:
    2 A3; 2 19.38 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (28950211..28977668)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (29060199..29087656)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene cilia and flagella associated protein 77 Neighboring gene STARR-positive B cell enhancer ABC_E4422 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:28916086-28916195 Neighboring gene STARR-seq mESC enhancer starr_04036 Neighboring gene STARR-seq mESC enhancer starr_04037 Neighboring gene STARR-seq mESC enhancer starr_04038 Neighboring gene STARR-seq mESC enhancer starr_04039 Neighboring gene ring finger and WD repeat domain 2 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:28980423-28980610 Neighboring gene STARR-positive B cell enhancer ABC_E5902 Neighboring gene STARR-seq mESC enhancer starr_04042 Neighboring gene STARR-seq mESC enhancer starr_04043 Neighboring gene senataxin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    transcription termination factor 1
    Names
    RNA polymerase I termination factor
    transcription termination factor I

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001421169.1NP_001408098.1  transcription termination factor 1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL845267
      UniProtKB/Swiss-Prot
      Q62187, Q9JKK5
    2. NM_001421170.1NP_001408099.1  transcription termination factor 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL845267
    3. NM_009442.2NP_033468.2  transcription termination factor 1 isoform a

      See identical proteins and their annotated locations for NP_033468.2

      Status: VALIDATED

      Source sequence(s)
      AK163606, BC059011, BE332152, BU757299
      Consensus CDS
      CCDS38089.1
      UniProtKB/Swiss-Prot
      Q62187, Q9JKK5
      Related
      ENSMUSP00000097809.4, ENSMUST00000100237.4
      Conserved Domains (1) summary
      pfam13921
      Location:595650
      Myb_DNA-bind_6; Myb-like DNA-binding domain

    RNA

    1. NR_185261.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL845267
    2. NR_185262.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL845267
    3. NR_185263.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL845267

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      28950211..28977668
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160512.1XP_036016405.1  transcription termination factor 1 isoform X1

      Conserved Domains (1) summary
      pfam13921
      Location:625680
      Myb_DNA-bind_6; Myb-like DNA-binding domain

    RNA

    1. XR_004939514.1 RNA Sequence

    2. XR_374068.2 RNA Sequence