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    Paxx non-homologous end joining factor [ Mus musculus (house mouse) ]

    Gene ID: 227622, updated on 9-Dec-2024

    Summary

    Official Symbol
    Paxxprovided by MGI
    Official Full Name
    non-homologous end joining factorprovided by MGI
    Primary source
    MGI:MGI:2442831
    See related
    Ensembl:ENSMUSG00000047617 AllianceGenome:MGI:2442831
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D930050G13Rik
    Summary
    Predicted to enable DNA polymerase binding activity; molecular adaptor activity; and protein homodimerization activity. Involved in double-strand break repair via nonhomologous end joining. Predicted to be located in nucleoplasm. Predicted to be part of Ku70:Ku80 complex and nonhomologous end joining complex. Predicted to be active in nucleus and site of double-strand break. Is expressed in brain; cortical plate; lung; spleen; and thymus. Orthologous to human PAXX (PAXX non-homologous end joining factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver adult (RPKM 28.1), thymus adult (RPKM 19.7) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Paxx in Genome Data Viewer
    Location:
    2 A3; 2 17.27 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25345132..25352666, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25455120..25462654, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene fucosyltransferase 7 Neighboring gene ATP-binding cassette, sub-family A member 2 Neighboring gene microRNA 3087 Neighboring gene STARR-positive B cell enhancer ABC_E2604 Neighboring gene chloride intracellular channel 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:25321339-25321522 Neighboring gene prostaglandin D2 synthase (brain) Neighboring gene predicted gene, 35287

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Clone Names

    • MGC36831

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA polymerase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA polymerase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables molecular adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in double-strand break repair via nonhomologous end joining IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in double-strand break repair via nonhomologous end joining IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in double-strand break repair via nonhomologous end joining ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in double-strand break repair via nonhomologous end joining ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of Ku70:Ku80 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Ku70:Ku80 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of nonhomologous end joining complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of nonhomologous end joining complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nonhomologous end joining complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in site of double-strand break IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
     
    located_in site of double-strand break ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    protein PAXX
    Names
    paralog of XRCC4 and XLF

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153557.2NP_705785.1  protein PAXX

      See identical proteins and their annotated locations for NP_705785.1

      Status: VALIDATED

      Source sequence(s)
      AL732557
      Consensus CDS
      CCDS15775.1
      UniProtKB/Swiss-Prot
      Q8C6V7, Q8K0Y7
      Related
      ENSMUSP00000109899.3, ENSMUST00000114261.9
      Conserved Domains (1) summary
      pfam15384
      Location:10205
      PAXX; PAXX, PAralog of XRCC4 and XLF, also called C9orf142

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      25345132..25352666 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249617.1XP_030105477.1  protein PAXX isoform X8

      Conserved Domains (1) summary
      pfam15384
      Location:10173
      PAXX; PAralog of XRCC4 and XLF, also called C9orf142
    2. XM_030249618.1XP_030105478.1  protein PAXX isoform X11

      UniProtKB/TrEMBL
      A2AJ30
      Related
      ENSMUSP00000120533.2, ENSMUST00000151239.2
      Conserved Domains (1) summary
      pfam15384
      Location:10193
      PAXX; PAralog of XRCC4 and XLF, also called C9orf142
    3. XM_036160674.1XP_036016567.1  protein PAXX isoform X2

      Conserved Domains (1) summary
      pfam15384
      Location:10165
      PAXX; PAralog of XRCC4 and XLF, also called C9orf142
    4. XM_006497865.4XP_006497928.1  protein PAXX isoform X7

      Conserved Domains (1) summary
      pfam15384
      Location:10174
      PAXX; PAralog of XRCC4 and XLF, also called C9orf142
    5. XM_006497867.4XP_006497930.1  protein PAXX isoform X10

      UniProtKB/TrEMBL
      A2AJ30
      Conserved Domains (1) summary
      pfam15384
      Location:10194
      PAXX; PAralog of XRCC4 and XLF, also called C9orf142
    6. XM_036160672.1XP_036016565.1  protein PAXX isoform X1

      Conserved Domains (1) summary
      pfam15384
      Location:10166
      PAXX; PAralog of XRCC4 and XLF, also called C9orf142
    7. XM_006497866.5XP_006497929.1  protein PAXX isoform X9

      Conserved Domains (1) summary
      pfam15384
      Location:10206
      PAXX; PAralog of XRCC4 and XLF, also called C9orf142
    8. XM_030249615.1XP_030105475.1  protein PAXX isoform X6

      Conserved Domains (1) summary
      pfam15384
      Location:10197
      PAXX; PAralog of XRCC4 and XLF, also called C9orf142
    9. XM_030249613.1XP_030105473.1  protein PAXX isoform X4

      Conserved Domains (1) summary
      pfam15384
      Location:10165
      PAXX; PAralog of XRCC4 and XLF, also called C9orf142
    10. XM_006497864.4XP_006497927.1  protein PAXX isoform X5

      Conserved Domains (1) summary
      pfam15384
      Location:10198
      PAXX; PAralog of XRCC4 and XLF, also called C9orf142
    11. XM_017317186.2XP_017172675.1  protein PAXX isoform X3

      Conserved Domains (1) summary
      pfam15384
      Location:10166
      PAXX; PAralog of XRCC4 and XLF, also called C9orf142