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    Acot8 acyl-CoA thioesterase 8 [ Mus musculus (house mouse) ]

    Gene ID: 170789, updated on 9-Dec-2024

    Summary

    Official Symbol
    Acot8provided by MGI
    Official Full Name
    acyl-CoA thioesterase 8provided by MGI
    Primary source
    MGI:MGI:2158201
    See related
    Ensembl:ENSMUSG00000017307 AllianceGenome:MGI:2158201
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pte1; PTE-1; PTE-2
    Summary
    Enables fatty acyl-CoA hydrolase activity. Acts upstream of or within acyl-CoA metabolic process. Located in peroxisome. Orthologous to human ACOT8 (acyl-CoA thioesterase 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 26.5), duodenum adult (RPKM 22.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Acot8 in Genome Data Viewer
    Location:
    2 H3; 2 85.27 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164634688..164662132, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (164792768..164820219, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2C Neighboring gene troponin C2, fast Neighboring gene sorting nexin family member 21 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:164630130-164630494 Neighboring gene zinc finger SWIM-type containing 3 Neighboring gene STARR-seq mESC enhancer starr_06336 Neighboring gene zinc finger SWIM-type containing 1 Neighboring gene spermatogenesis associated 25

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acetoacetyl-CoA hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables acetyl-CoA hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables choloyl-CoA hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables choloyl-CoA hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables fatty acyl-CoA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables fatty acyl-CoA hydrolase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables fatty acyl-CoA hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydroxymethylglutaryl-CoA hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables long-chain fatty acyl-CoA hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables long-chain fatty acyl-CoA hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables medium-chain fatty acyl-CoA hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables medium-chain fatty acyl-CoA hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables succinyl-CoA hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in acyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within acyl-CoA metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in acyl-CoA metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dicarboxylic acid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dicarboxylic acid catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fatty acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of CD4 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of CD4 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in peroxisome fission IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peroxisome fission ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in peroxisomal matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in peroxisomal matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in peroxisomal matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    acyl-coenzyme A thioesterase 8
    Names
    choloyl-coenzyme A thioesterase
    peroxisomal acyl-CoA thioesterase 1
    peroxisomal acyl-CoA thioesterase 2
    peroxisomal acyl-coenzyme A thioester hydrolase 1
    peroxisomal long-chain acyl-CoA thioesterase 1
    NP_001349685.1
    NP_001349686.1
    NP_573503.2
    XP_006498892.1
    XP_006498894.1
    XP_011237620.1
    XP_011237621.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362756.1NP_001349685.1  acyl-coenzyme A thioesterase 8 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK033724, AL591127
      Consensus CDS
      CCDS89580.1
      UniProtKB/TrEMBL
      Q8BZR4
      Related
      ENSMUSP00000017451.7, ENSMUST00000017451.7
      Conserved Domains (1) summary
      cl26120
      Location:35246
      4HBT_3; Thioesterase-like superfamily
    2. NM_001362757.1NP_001349686.1  acyl-coenzyme A thioesterase 8 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AL591127
      Conserved Domains (1) summary
      TIGR00189
      Location:3228
      tesB; acyl-CoA thioesterase II
    3. NM_133240.2NP_573503.2  acyl-coenzyme A thioesterase 8 isoform 1

      See identical proteins and their annotated locations for NP_573503.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AI122325, AK151924, BB604985
      Consensus CDS
      CCDS17057.1
      UniProtKB/Swiss-Prot
      P58137, Q8VHM4
      UniProtKB/TrEMBL
      Q3U965
      Related
      ENSMUSP00000099383.5, ENSMUST00000103094.11
      Conserved Domains (3) summary
      cd03444
      Location:206309
      Thioesterase_II_repeat1; Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP) ...
      cd03445
      Location:40131
      Thioesterase_II_repeat2; Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP) ...
      TIGR00189
      Location:35310
      tesB; acyl-CoA thioesterase II

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      164634688..164662132 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498831.5XP_006498894.1  acyl-coenzyme A thioesterase 8 isoform X4

      Conserved Domains (1) summary
      TIGR00189
      Location:2179
      tesB; acyl-CoA thioesterase II
    2. XM_006498829.2XP_006498892.1  acyl-coenzyme A thioesterase 8 isoform X2

      Conserved Domains (1) summary
      TIGR00189
      Location:3227
      tesB; acyl-CoA thioesterase II
    3. XM_011239318.4XP_011237620.1  acyl-coenzyme A thioesterase 8 isoform X1

      Conserved Domains (1) summary
      TIGR00189
      Location:9230
      tesB; acyl-CoA thioesterase II
    4. XM_011239319.2XP_011237621.1  acyl-coenzyme A thioesterase 8 isoform X3

      Conserved Domains (1) summary
      TIGR00189
      Location:3224
      tesB; acyl-CoA thioesterase II

    RNA

    1. XR_001781109.3 RNA Sequence

      Related
      ENSMUST00000134611.4