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    Hipk1 homeodomain interacting protein kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 15257, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hipk1provided by MGI
    Official Full Name
    homeodomain interacting protein kinase 1provided by MGI
    Primary source
    MGI:MGI:1314873
    See related
    Ensembl:ENSMUSG00000008730 AllianceGenome:MGI:1314873
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Myak; 1110062K04Rik
    Summary
    Predicted to enable protein serine/threonine kinase activity; protein tyrosine kinase activity; and transcription corepressor activity. Involved in adherens junction assembly; camera-type eye morphogenesis; and neuron differentiation. Acts upstream of or within several processes, including anterior/posterior pattern specification; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; and smoothened signaling pathway. Located in PML body; cytoplasm; and nuclear speck. Is expressed in several structures, including forebrain ventricular layer and future forebrain. Orthologous to human HIPK1 (homeodomain interacting protein kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 35.2), testis adult (RPKM 31.7) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Hipk1 in Genome Data Viewer
    Location:
    3 F2.2; 3 45.52 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (103647131..103699210, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (103739815..103791894, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108168889 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:103542020-103542203 Neighboring gene STARR-positive B cell enhancer ABC_E6093 Neighboring gene olfactomedin-like 3 Neighboring gene STARR-seq mESC enhancer starr_08602 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:103577942-103578125 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:103581922-103582188 Neighboring gene predicted gene 15886 Neighboring gene DNA cross-link repair 1B Neighboring gene STARR-positive B cell enhancer ABC_E11207 Neighboring gene predicted gene 15471 Neighboring gene adaptor-related protein complex AP-4, beta 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    NOT enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription corepressor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in adherens junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within anterior/posterior pattern specification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic camera-type eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in embryonic retina morphogenesis in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endothelial cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endothelial cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in extrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in iris morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lens induction in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in regulation of tumor necrosis factor-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retina layer formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in smoothened signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within smoothened signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in PML body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in PML body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    homeodomain-interacting protein kinase 1
    Names
    nuclear body-associated kinase 2
    protein kinase Myak
    NP_001288233.1
    NP_001288235.1
    NP_034562.2
    XP_011238326.1
    XP_036018798.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301304.1NP_001288233.1  homeodomain-interacting protein kinase 1 isoform 1

      See identical proteins and their annotated locations for NP_001288233.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC132567
      Consensus CDS
      CCDS38576.1
      UniProtKB/Swiss-Prot
      A6H5Z7, O88904, Q80TV5, Q9QUQ8, Q9QZR3, Q9WVN7
      Related
      ENSMUSP00000113998.2, ENSMUST00000118317.8
      Conserved Domains (1) summary
      cd14228
      Location:174528
      STKc_HIPK1; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1
    2. NM_001301306.1NP_001288235.1  homeodomain-interacting protein kinase 1 isoform 2

      See identical proteins and their annotated locations for NP_001288235.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in central coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC132567
      Consensus CDS
      CCDS79992.1
      UniProtKB/Swiss-Prot
      O88904
      Related
      ENSMUSP00000102458.3, ENSMUST00000106845.9
      Conserved Domains (2) summary
      smart00220
      Location:190518
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14228
      Location:174528
      STKc_HIPK1; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1
    3. NM_010432.2NP_034562.2  homeodomain-interacting protein kinase 1 isoform 1

      See identical proteins and their annotated locations for NP_034562.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript ans encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC132567, AF170304, AK134408, AW125573
      Consensus CDS
      CCDS38576.1
      UniProtKB/Swiss-Prot
      A6H5Z7, O88904, Q80TV5, Q9QUQ8, Q9QZR3, Q9WVN7
      Related
      ENSMUSP00000029438.9, ENSMUST00000029438.15
      Conserved Domains (1) summary
      cd14228
      Location:174528
      STKc_HIPK1; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1

    RNA

    1. NR_125731.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most [supported/expected] translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC132567
      Related
      ENSMUST00000137078.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      103647131..103699210 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240024.2XP_011238326.1  homeodomain-interacting protein kinase 1 isoform X2

      Conserved Domains (1) summary
      cd14228
      Location:174528
      STKc_HIPK1; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1
    2. XM_036162905.1XP_036018798.1  homeodomain-interacting protein kinase 1 isoform X1

      UniProtKB/Swiss-Prot
      A6H5Z7, O88904, Q80TV5, Q9QUQ8, Q9QZR3, Q9WVN7
      Conserved Domains (1) summary
      cd14228
      Location:174528
      STKc_HIPK1; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1

    RNA

    1. XR_003954293.2 RNA Sequence

    2. XR_004941290.1 RNA Sequence