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    Crebzf CREB/ATF bZIP transcription factor [ Mus musculus (house mouse) ]

    Gene ID: 233490, updated on 9-Dec-2024

    Summary

    Official Symbol
    Crebzfprovided by MGI
    Official Full Name
    CREB/ATF bZIP transcription factorprovided by MGI
    Primary source
    MGI:MGI:2675296
    See related
    Ensembl:ENSMUSG00000051451 AllianceGenome:MGI:2675296
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zf; LAZip; SMILE; LAZipII; 1110034C16Rik; 6330417B10Rik
    Summary
    Predicted to enable identical protein binding activity and sequence-specific DNA binding activity. Predicted to be involved in negative regulation of gene expression, epigenetic; regulation of DNA-templated transcription; and response to virus. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including early embryo; foot mesenchyme; nervous system; retina; and uterus. Orthologous to human CREBZF (CREB/ATF bZIP transcription factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 27.9), ovary adult (RPKM 27.4) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Crebzf in Genome Data Viewer
    Location:
    7 E1; 7 50.59 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (90091942..90097590)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (90442734..90448382)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene synaptotagmin-like 2 Neighboring gene STARR-seq mESC enhancer starr_19508 Neighboring gene STARR-seq mESC enhancer starr_19509 Neighboring gene STARR-seq mESC enhancer starr_19510 Neighboring gene STARR-seq mESC enhancer starr_19511 Neighboring gene coiled-coil domain containing 89 Neighboring gene STARR-positive B cell enhancer ABC_E10450 Neighboring gene transmembrane protein 126A Neighboring gene STARR-positive B cell enhancer ABC_E352 Neighboring gene transmembrane protein 126B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of RNA polymerase II transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    CREB/ATF bZIP transcription factor
    Names
    HCF-binding transcription factor Zhangfei
    host cell factor-binding transcription factor Zhangfei
    tyrosine kinase-associated leucine zipper protein LAZip
    tyrosine kinase-associated leucine zipper protein LAZipII

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145151.3NP_660133.2  CREB/ATF bZIP transcription factor

      See identical proteins and their annotated locations for NP_660133.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein.
      Source sequence(s)
      AC100322, AK004085
      Consensus CDS
      CCDS40020.1
      UniProtKB/Swiss-Prot
      Q91Y72, Q91ZR3
      Related
      ENSMUSP00000050972.6, ENSMUST00000061767.5
      Conserved Domains (1) summary
      cl21462
      Location:223264
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

    RNA

    1. NR_073436.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate internal segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC100322, AK004085, BI990274
    2. NR_073437.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate internal segments, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC100322, CX237465
    3. NR_073438.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks three alternate internal segments, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AA028814, AC100322, BG094109

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      90091942..90097590
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507606.2XP_006507669.1  CREB/ATF bZIP transcription factor isoform X1

      See identical proteins and their annotated locations for XP_006507669.1

      UniProtKB/Swiss-Prot
      Q91Y72, Q91ZR3
      Conserved Domains (1) summary
      cl21462
      Location:223264
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain