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    UNC119B unc-119 lipid binding chaperone B [ Homo sapiens (human) ]

    Gene ID: 84747, updated on 9-Dec-2024

    Summary

    Official Symbol
    UNC119Bprovided by HGNC
    Official Full Name
    unc-119 lipid binding chaperone Bprovided by HGNC
    Primary source
    HGNC:HGNC:16488
    See related
    Ensembl:ENSG00000175970 MIM:620513; AllianceGenome:HGNC:16488
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    POC7B
    Summary
    Enables lipid binding activity. Involved in cilium assembly and lipoprotein transport. Located in ciliary transition zone. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 22.0), ovary (RPKM 19.5) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See UNC119B in Genome Data Viewer
    Location:
    12q24.31
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (120710458..120723640)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (120699614..120712778)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (121148261..121161443)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene calcium binding protein 1 Neighboring gene uncharacterized LOC105370029 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7147 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4961 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4962 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7148 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7149 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:121124755-121125256 Neighboring gene uncharacterized LOC124903035 Neighboring gene uncharacterized LOC124903036 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:121148178-121149020 Neighboring gene malectin Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:121163301-121163802 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121176341-121177046 Neighboring gene microRNA 4700 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:121185508-121185723 Neighboring gene acyl-CoA dehydrogenase short chain Neighboring gene ReSE screen-validated silencer GRCh37_chr12:121200901-121201064 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121209105-121209605 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:121220845-121222044 Neighboring gene signal peptide peptidase like 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7150 Neighboring gene ARF GTPase 1 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    An atlas of genetic influences on human blood metabolites.
    EBI GWAS Catalog
    Human metabolic individuality in biomedical and pharmaceutical research.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC5139

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables lipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables lipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lipoprotein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in lipoprotein transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in ciliary transition zone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cilium TAS
    Traceable Author Statement
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    protein unc-119 homolog B
    Names
    POC7 centriolar protein homolog B
    unc-119 homolog B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080533.3NP_001074002.1  protein unc-119 homolog B

      See identical proteins and their annotated locations for NP_001074002.1

      Status: VALIDATED

      Source sequence(s)
      AC069234, AL137327, BC070088, DA324219
      Consensus CDS
      CCDS31914.1
      UniProtKB/Swiss-Prot
      A6NIH7
      UniProtKB/TrEMBL
      B3KX02
      Related
      ENSP00000344942.4, ENST00000344651.5
      Conserved Domains (1) summary
      pfam05351
      Location:89247
      GMP_PDE_delta; GMP-PDE, delta subunit

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      120710458..120723640
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      120699614..120712778
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_032661.1: Suppressed sequence

      Description
      NM_032661.1: This RefSeq was permanently suppressed because it contains the wrong CDS.