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    NOL3 nucleolar protein 3 [ Homo sapiens (human) ]

    Gene ID: 8996, updated on 9-Dec-2024

    Summary

    Official Symbol
    NOL3provided by HGNC
    Official Full Name
    nucleolar protein 3provided by HGNC
    Primary source
    HGNC:HGNC:7869
    See related
    Ensembl:ENSG00000140939 MIM:605235; AllianceGenome:HGNC:7869
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARC; FCM; MYP; NOP; NOP30; MYOCL1
    Summary
    This gene encodes an anti-apoptotic protein that has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
    Expression
    Ubiquitous expression in skin (RPKM 15.7), prostate (RPKM 15.6) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See NOL3 in Genome Data Viewer
    Location:
    16q22.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (67170538..67175737)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (72964831..72970031)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67204441..67209640)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67189519-67190420 Neighboring gene TNFRSF1A associated via death domain Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10952 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7584 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7585 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67195788-67196300 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67196374-67197322 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67197323-67198271 Neighboring gene F-box and leucine rich repeat protein 8 Neighboring gene Sharpr-MPRA regulatory region 11796 Neighboring gene heat shock transcription factor 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10954 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10955 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7588 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:67206328-67206491 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67207408-67208330 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:67209861-67210290 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67211873-67212416 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67212417-67212958 Neighboring gene microtubule associated tyrosine carboxypeptidase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10956 Neighboring gene exocyst complex component 3 like 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67225781-67226711 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10958 Neighboring gene E2F transcription factor 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7593

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of nucleolar protein 3, apoptosis repressor with CARD domain (NOL3) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ35304

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables calcium ion binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables caspase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables caspase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables death effector domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables death receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in blood vessel remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cardiac muscle cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA splice site recognition IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cardiac muscle cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cysteine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of extrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of extrinsic apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of intrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of mitochondrial membrane permeability involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of muscle atrophy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of programmed necrotic cell death IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of release of cytochrome c from mitochondria IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of release of cytochrome c from mitochondria IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of tumor necrosis factor-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein complex oligomerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of non-canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to injury involved in regulation of muscle adaptation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ischemia IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sarcoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    nucleolar protein 3
    Names
    muscle-enriched cytoplasmic protein
    nucleolar protein 3 (apoptosis repressor with CARD domain)
    nucleolar protein of 30 kDa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029566.1 RefSeqGene

      Range
      8352..10236
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001185057.3NP_001171986.1  nucleolar protein 3 isoform Nop30

      See identical proteins and their annotated locations for NP_001171986.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) originates from a different promoter, has a shorter 5' UTR, and uses an alternate splice site in the CDS, compared to variant 1. This transcript and protein were described by Stoss et al. (PMID: 10196175). The resulting protein (Nop30) has the same N-terminus and then is frameshifted resulting in a distinct C-terminus, compared to isoform MYP.
      Source sequence(s)
      AC074143
      Consensus CDS
      CCDS58473.1
      UniProtKB/TrEMBL
      H3BQJ5
      Related
      ENSP00000454598.1, ENST00000568146.1
      Conserved Domains (1) summary
      cl14633
      Location:592
      DD; Death Domain Superfamily of protein-protein interaction domains
    2. NM_001276307.3NP_001263236.1  nucleolar protein 3 isoform MYP

      See identical proteins and their annotated locations for NP_001263236.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 4, and 5 encode the same protein (isoform MYP).
      Source sequence(s)
      AC074143
      Consensus CDS
      CCDS42176.1
      UniProtKB/Swiss-Prot
      B4DFL0, O60936, O60937
      UniProtKB/TrEMBL
      Q5TZN6
      Conserved Domains (1) summary
      cl14633
      Location:592
      DD; Death Domain Superfamily of protein-protein interaction domains
    3. NM_001276309.3NP_001263238.1  nucleolar protein 3 isoform MYP

      See identical proteins and their annotated locations for NP_001263238.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 4, and 5 encode the same protein (isoform MYP).
      Source sequence(s)
      AC074143
      Consensus CDS
      CCDS42176.1
      UniProtKB/Swiss-Prot
      B4DFL0, O60936, O60937
      UniProtKB/TrEMBL
      Q5TZN6
      Related
      ENSP00000457720.2, ENST00000564992.2
      Conserved Domains (1) summary
      cl14633
      Location:592
      DD; Death Domain Superfamily of protein-protein interaction domains
    4. NM_001276311.2NP_001263240.1  nucleolar protein 3 isoform C

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses an alternate splice site in the CDS compared to variant 1. The resulting protein has the same N-terminus and then is frame-shifted resulting in a distinct C-terminus, compared to isoform MYP.
      Source sequence(s)
      AC074143
      UniProtKB/TrEMBL
      H3BQJ5
      Related
      ENSP00000455808.1, ENST00000566871.5
      Conserved Domains (2) summary
      cl00281
      Location:30115
      metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
      cl14633
      Location:558
      DD; Death Domain Superfamily of protein-protein interaction domains
    5. NM_001276312.3NP_001263241.1  nucleolar protein 3 isoform MYP

      See identical proteins and their annotated locations for NP_001263241.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform. Variants 1, 2, 4, and 5 encode the same protein (isoform MYP).
      Source sequence(s)
      AC074143
      Consensus CDS
      CCDS42176.1
      UniProtKB/Swiss-Prot
      B4DFL0, O60936, O60937
      UniProtKB/TrEMBL
      Q5TZN6
      Related
      ENSP00000457243.2, ENST00000564053.5
      Conserved Domains (1) summary
      cl14633
      Location:592
      DD; Death Domain Superfamily of protein-protein interaction domains
    6. NM_001394973.1NP_001381902.1  nucleolar protein 3 isoform MYP

      Status: REVIEWED

      Source sequence(s)
      AC074143
      Consensus CDS
      CCDS42176.1
      UniProtKB/Swiss-Prot
      B4DFL0, O60936, O60937
      UniProtKB/TrEMBL
      Q5TZN6
      Conserved Domains (1) summary
      cl14633
      Location:592
      DD; Death Domain Superfamily of protein-protein interaction domains
    7. NM_001394974.1NP_001381903.1  nucleolar protein 3 isoform C

      Status: REVIEWED

      Source sequence(s)
      AC074143
      UniProtKB/TrEMBL
      H3BQJ5
      Conserved Domains (2) summary
      cl00281
      Location:30115
      metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
      cl14633
      Location:558
      DD; Death Domain Superfamily of protein-protein interaction domains
    8. NM_001394975.1NP_001381904.1  nucleolar protein 3 isoform C

      Status: REVIEWED

      Source sequence(s)
      AC074143
      UniProtKB/TrEMBL
      H3BQJ5
      Conserved Domains (2) summary
      cl00281
      Location:30115
      metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
      cl14633
      Location:558
      DD; Death Domain Superfamily of protein-protein interaction domains
    9. NM_001394976.1NP_001381905.1  nucleolar protein 3 isoform C

      Status: REVIEWED

      Source sequence(s)
      AC074143
      UniProtKB/TrEMBL
      H3BQJ5
      Conserved Domains (2) summary
      cl00281
      Location:30115
      metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
      cl14633
      Location:558
      DD; Death Domain Superfamily of protein-protein interaction domains
    10. NM_001394977.1NP_001381906.1  nucleolar protein 3 isoform Nop30

      Status: REVIEWED

      Source sequence(s)
      AC074143
      Consensus CDS
      CCDS58473.1
      UniProtKB/TrEMBL
      H3BQJ5
      Conserved Domains (1) summary
      cl14633
      Location:592
      DD; Death Domain Superfamily of protein-protein interaction domains
    11. NM_001394978.1NP_001381907.1  nucleolar protein 3 isoform Nop30

      Status: REVIEWED

      Source sequence(s)
      AC074143
      Consensus CDS
      CCDS58473.1
      UniProtKB/TrEMBL
      H3BQJ5
      Conserved Domains (1) summary
      cl14633
      Location:592
      DD; Death Domain Superfamily of protein-protein interaction domains
    12. NM_001394979.1NP_001381908.1  nucleolar protein 3 isoform E

      Status: REVIEWED

      Source sequence(s)
      AC074143
      Conserved Domains (1) summary
      cl14633
      Location:592
      DD; Death Domain Superfamily of protein-protein interaction domains
    13. NM_003946.7NP_003937.1  nucleolar protein 3 isoform MYP

      See identical proteins and their annotated locations for NP_003937.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) originates from a different promoter and has a shorter 5' UTR, compared to variant 1. This transcript and protein were described by Stoss et al. (PMID: 10196175). Variants 1, 2, 4 and 5 encode the same protein (isoform MYP).
      Source sequence(s)
      AC074143
      Consensus CDS
      CCDS42176.1
      UniProtKB/Swiss-Prot
      B4DFL0, O60936, O60937
      UniProtKB/TrEMBL
      Q5TZN6
      Related
      ENST00000568503.1
      Conserved Domains (1) summary
      cl14633
      Location:592
      DD; Death Domain Superfamily of protein-protein interaction domains

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      67170538..67175737
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434851.1XP_047290807.1  nucleolar protein 3 isoform X2

    2. XM_047434852.1XP_047290808.1  nucleolar protein 3 isoform X3

      UniProtKB/Swiss-Prot
      B4DFL0, O60936, O60937
      UniProtKB/TrEMBL
      Q5TZN6
    3. XM_047434850.1XP_047290806.1  nucleolar protein 3 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      72964831..72970031
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054314289.1XP_054170264.1  nucleolar protein 3 isoform X2

    2. XM_054314290.1XP_054170265.1  nucleolar protein 3 isoform X3

      UniProtKB/Swiss-Prot
      B4DFL0, O60936, O60937
      UniProtKB/TrEMBL
      Q5TZN6
    3. XM_054314288.1XP_054170263.1  nucleolar protein 3 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001185058.1: Suppressed sequence

      Description
      NM_001185058.1: This RefSeq has been replaced by NM_001276312.1.
    2. NM_001276319.2: Suppressed sequence

      Description
      NM_001276319.2: This RefSeq was removed because currently there is support for the transcript but not for the protein.