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    METTL26 methyltransferase like 26 [ Homo sapiens (human) ]

    Gene ID: 84326, updated on 3-Dec-2024

    Summary

    Official Symbol
    METTL26provided by HGNC
    Official Full Name
    methyltransferase like 26provided by HGNC
    Primary source
    HGNC:HGNC:14141
    See related
    Ensembl:ENSG00000130731 AllianceGenome:HGNC:14141
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    JFP2; C16orf13
    Expression
    Ubiquitous expression in kidney (RPKM 12.8), ovary (RPKM 12.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See METTL26 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (634430..636305, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (638463..640372, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (684430..686305, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene RAB40C, member RAS oncogene family Neighboring gene uncharacterized LOC124903618 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6927 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10208 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:671701-672454 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:677407-678140 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:679610-680343 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:680344-681078 Neighboring gene WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:685245-685904 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6928 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6929 Neighboring gene uncharacterized LOC100287175 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:687335-688109 Neighboring gene tRNA-Gly (anticodon CCC) 2-2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    methyltransferase-like 26
    Names
    UPF0585 protein C16orf13

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040160.3NP_001035250.1  methyltransferase-like 26 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the central coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b) has a longer and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK295628, BU539308, DB499720
      Consensus CDS
      CCDS42091.1
      UniProtKB/Swiss-Prot
      Q96S19
      Related
      ENSP00000440765.2, ENST00000397666.6
      Conserved Domains (1) summary
      cl17173
      Location:4140
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. NM_001040161.3NP_001035251.1  methyltransferase-like 26 isoform c

      See identical proteins and their annotated locations for NP_001035251.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks three exons in the central coding region, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a.
      Source sequence(s)
      BC007207
      Consensus CDS
      CCDS32352.1
      UniProtKB/Swiss-Prot
      Q96S19
      Related
      ENSP00000444140.2, ENST00000338401.8
      Conserved Domains (1) summary
      cl17173
      Location:4106
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    3. NM_001040162.3NP_001035252.1  methyltransferase-like 26 isoform d

      See identical proteins and their annotated locations for NP_001035252.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two exons in the central coding region, which results in a frameshift, compared to variant 1. The encoded isoform (d) is shorter and has a distinct internal segment, compared to isoform a.
      Source sequence(s)
      BM827705, BU539308, DB499720
      Consensus CDS
      CCDS45367.1
      UniProtKB/Swiss-Prot
      Q96S19
      Related
      ENSP00000440475.2, ENST00000397664.8
      Conserved Domains (1) summary
      cl17173
      Location:4126
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    4. NM_001040165.3NP_001035255.1  methyltransferase-like 26 isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks two exons in the central coding region, which results in a frameshift, compared to variant 1. The encoded isoform (g) is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AI146806, BU539308, DB499720
      Consensus CDS
      CCDS42090.1
      UniProtKB/Swiss-Prot
      Q96S19
      Related
      ENSP00000444460.2, ENST00000397665.6
      Conserved Domains (1) summary
      cl17173
      Location:4134
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    5. NM_001288710.2NP_001275639.1  methyltransferase-like 26 isoform h

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (h) is shorter, compared to isoform 1.
      Source sequence(s)
      BP273946, BU539308, DB499720
      Consensus CDS
      CCDS73798.1
      UniProtKB/TrEMBL
      A0A087WYU2
      Related
      ENSP00000482089.1, ENST00000614890.4
      Conserved Domains (1) summary
      cl17173
      Location:4183
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    6. NM_032366.5NP_115742.3  methyltransferase-like 26 isoform a

      See identical proteins and their annotated locations for NP_115742.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform a.
      Source sequence(s)
      AK294482, DB499720
      Consensus CDS
      CCDS45368.1
      UniProtKB/Swiss-Prot
      A8MTR1, A8MWJ8, A8MZA1, B4DG95, B4DIJ3, D6REA6, F6TF62, F6VM53, Q96IW1, Q96MD6, Q96S19
      Related
      ENSP00000445926.2, ENST00000301686.13
      Conserved Domains (1) summary
      pfam06080
      Location:4203
      DUF938; Protein of unknown function (DUF938)

    RNA

    1. NR_109976.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an internal exon and uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AW027232, BU539308, DB499720
    2. NR_109977.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK294482, DB499720
      Related
      ENST00000568077.5
    3. NR_109978.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK294482, BI762987, BU539308, DB499720
      Related
      ENST00000456420.6
    4. NR_109979.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) lacks two internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BU539308, DB499720

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      634430..636305 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011522714.3XP_011521016.1  methyltransferase-like 26 isoform X2

      UniProtKB/TrEMBL
      H3BNB2
      Conserved Domains (1) summary
      cl17173
      Location:4120
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. XM_011522713.3XP_011521015.1  methyltransferase-like 26 isoform X1

      Conserved Domains (1) summary
      cl17173
      Location:4270
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    3. XM_047434800.1XP_047290756.1  methyltransferase-like 26 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      638463..640372 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054314190.1XP_054170165.1  methyltransferase-like 26 isoform X2

      UniProtKB/TrEMBL
      H3BNB2
    2. XM_054314189.1XP_054170164.1  methyltransferase-like 26 isoform X1

    3. XM_054314191.1XP_054170166.1  methyltransferase-like 26 isoform X3

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001040163.1: Suppressed sequence

      Description
      NM_001040163.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    2. NM_001040164.1: Suppressed sequence

      Description
      NM_001040164.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    3. NM_001040166.1: Suppressed sequence

      Description
      NM_001040166.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.