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    LUZP4 leucine zipper protein 4 [ Homo sapiens (human) ]

    Gene ID: 51213, updated on 9-Dec-2024

    Summary

    Official Symbol
    LUZP4provided by HGNC
    Official Full Name
    leucine zipper protein 4provided by HGNC
    Primary source
    HGNC:HGNC:24971
    See related
    Ensembl:ENSG00000102021 MIM:300616; AllianceGenome:HGNC:24971
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT-8; CT28; CT-28; HOM-TES-85
    Summary
    This gene encodes a leucine-zipper protein that was first defined as a cancer testis antigens. The encoded protein is an RNA binding protein that interacts with the mRNA export receptor nuclear RNA export factor 2. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
    Expression
    Restricted expression toward testis (RPKM 5.6) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See LUZP4 in Genome Data Viewer
    Location:
    Xq23
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (115289715..115307563)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (113698307..113716155)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (114524281..114542128)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene leucine rich repeats and calponin homology domain containing 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:114424095-114424596 Neighboring gene RBMX like 3 Neighboring gene ribosomal protein L36 pseudogene 18 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:114552544-114553121 Neighboring gene uncharacterized LOC107985681 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:114579651-114580150 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chrX:114606578-114607435 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:114607575-114608077 Neighboring gene NANOG hESC enhancer GRCh37_chrX:114633821-114634394 Neighboring gene tubulin alpha pseudogene 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    leucine zipper protein 4
    Names
    HOM-TES-85 tumor antigen
    cancer/testis antigen 28
    tumor antigen HOM-TES-85

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021297.2 RefSeqGene

      Range
      4995..22843
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001318840.2NP_001305769.1  leucine zipper protein 4 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' coding region which results in the use of a an alternate 5' most exon and a frameshift in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC239923, AF124430, AK093369, DB035084
      UniProtKB/Swiss-Prot
      Q9P127
      Conserved Domains (1) summary
      pfam12316
      Location:48147
      Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal
    2. NM_016383.5NP_057467.1  leucine zipper protein 4 isoform 1

      See identical proteins and their annotated locations for NP_057467.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC239923, AF124430, AK093369, DB035084
      Consensus CDS
      CCDS14567.1
      UniProtKB/Swiss-Prot
      B3KSD6, Q9P127
      Related
      ENSP00000360988.3, ENST00000371920.4
      Conserved Domains (1) summary
      pfam07078
      Location:14116
      FYTT; Forty-two-three protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      115289715..115307563
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      113698307..113716155
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)