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    Psg16 pregnancy specific beta-1-glycoprotein 16 [ Mus musculus (house mouse) ]

    Gene ID: 26436, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Psg16provided by MGI
    Official Full Name
    pregnancy specific beta-1-glycoprotein 16provided by MGI
    Primary source
    MGI:MGI:1347249
    See related
    Ensembl:ENSMUSG00000066760 AllianceGenome:MGI:1347249
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PSG; bCEA; Cea11
    Summary
    Predicted to be involved in T cell activation and immune response. Located in cell surface. Is expressed in brain; lung; placenta; and spleen. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in placenta adult (RPKM 7.7) and cerebellum adult (RPKM 1.6) See more
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    Genomic context

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    See Psg16 in Genome Data Viewer
    Location:
    7 A2; 7 9.15 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (16807938..16867375)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (17074013..17133450)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 5, catalytic subunit Neighboring gene hypoxia inducible factor 3, alpha subunit Neighboring gene STARR-seq mESC enhancer starr_18149 Neighboring gene predicted gene 45219 Neighboring gene ribosomal protein L15 pseudogene Neighboring gene CEA cell adhesion molecule 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel full-length isoform of murine pregnancy-specific glycoprotein 16 (psg16) is expressed in the brain but does not mediate murine coronavirus (MHV) entry. Phillips JM, et al. J Neurovirol, 2012 Apr. PMID 22302612, Free PMC Article
    2. A pregnancy-specific glycoprotein is expressed in the brain and serves as a receptor for mouse hepatitis virus. Chen DS, et al. Proc Natl Acad Sci U S A, 1995 Dec 19. PMID 8618851, Free PMC Article
    3. Role of mouse hepatitis virus (MHV) receptor murine CEACAM1 in the resistance of mice to MHV infection: studies of mice with chimeric mCEACAM1a and mCEACAM1b. Hirai A, et al. J Virol, 2010 Jul. PMID 20410265, Free PMC Article
    4. Structure and evolution of the mouse pregnancy-specific glycoprotein (Psg) gene locus. McLellan AS, et al. BMC Genomics, 2005 Jan 12. PMID 15647114, Free PMC Article
    5. Effects of Pparγ1 deletion on late-stage murine embryogenesis and cells that undergo endocycle. Nakano T, et al. Dev Biol, 2021 Oct. PMID 34246625

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PSG16 does not mediate CEACAM1a-independent spread of murine coronavirus.
      Title: A novel full-length isoform of murine pregnancy-specific glycoprotein 16 (psg16) is expressed in the brain but does not mediate murine coronavirus (MHV) entry.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pregnancy specific glycoprotein 16
    Names
    carcinoembryonic antigen 11

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310628.1 → NP_001297557.1  pregnancy specific glycoprotein 16 isoform 1

      See identical proteins and their annotated locations for NP_001297557.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC148976
      Consensus CDS
      CCDS80666.1
      UniProtKB/TrEMBL
      Q60962, Q8K0U8
      Related
      ENSMUSP00000071348.7, ENSMUST00000071399.13
      Conserved Domains (4) summary
      cd05774
      Location:67 → 171
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00408
      Location:311 → 364
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:306 → 363
      IG_like; Immunoglobulin like
      cl11960
      Location:1 → 48
      Ig; Immunoglobulin domain

    2. NM_007676.4 → NP_031702.3  pregnancy specific glycoprotein 16 isoform 2

      See identical proteins and their annotated locations for NP_031702.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a 3' exon and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BC030357, CK021085, U34272
      Consensus CDS
      CCDS20861.2
      UniProtKB/TrEMBL
      D0VY58, Q60962
      Related
      ENSMUSP00000113025.3, ENSMUST00000118367.3
      Conserved Domains (3) summary
      smart00408
      Location:311 → 369
      IGc2; Immunoglobulin C-2 Type
      cd05774
      Location:67 → 171
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      cl11960
      Location:1 → 48
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      16807938..16867375
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242606.1 → XP_030098466.1  pregnancy specific glycoprotein 16 isoform X1

      UniProtKB/TrEMBL
      Q60962
      Conserved Domains (2) summary
      cd05740
      Location:388 → 475
      IgI_hCEACAM_2_4_6_like; Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) domains 2, 4, and 6, and similar domains
      cd05774
      Location:158 → 262
      IgV_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

    2. XM_030242607.1 → XP_030098467.1  pregnancy specific glycoprotein 16 isoform X2

      UniProtKB/TrEMBL
      D0VY58, Q60962
      Conserved Domains (3) summary
      smart00408
      Location:311 → 369
      IGc2; Immunoglobulin C-2 Type
      cd05774
      Location:67 → 171
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      cl11960
      Location:1 → 48
      Ig; Immunoglobulin domain

    3. XM_036153135.1 → XP_036009028.1  pregnancy specific glycoprotein 16 isoform X1

      UniProtKB/TrEMBL
      Q60962
      Conserved Domains (2) summary
      cd05740
      Location:388 → 475
      IgI_hCEACAM_2_4_6_like; Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) domains 2, 4, and 6, and similar domains
      cd05774
      Location:158 → 262
      IgV_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    Nucleotide Protein Strain
    Heading Accession and Version

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