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    Sftpb surfactant associated protein B [ Mus musculus (house mouse) ]

    Gene ID: 20388, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Sftpbprovided by MGI
    Official Full Name
    surfactant associated protein Bprovided by MGI
    Primary source
    MGI:MGI:109516
    See related
    Ensembl:ENSMUSG00000056370 AllianceGenome:MGI:109516
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SF-B; SP-B; Sftp3; Sftp-3
    Summary
    Predicted to be involved in respiratory gaseous exchange by respiratory system and sphingolipid metabolic process. Located in cytoplasm. Is expressed in lung surfactant and respiratory system. Human ortholog(s) of this gene implicated in lung disease (multiple); respiratory syncytial virus infectious disease; and toxic shock syndrome. Orthologous to human SFTPB (surfactant protein B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward lung adult (RPKM 2635.4) See more
    Orthologs
    human all
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    Genomic context

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    See Sftpb in Genome Data Viewer
    Location:
    6 C1; 6 32.27 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (72281594..72291354)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (72304610..72314373)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene atonal bHLH transcription factor 8 Neighboring gene predicted gene, 52906 Neighboring gene predicted gene, 30782 Neighboring gene STARR-seq mESC enhancer starr_16282 Neighboring gene ubiquitin specific peptidase 39 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:72295216-72295399 Neighboring gene RIKEN cDNA 0610030E20 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Pulmonary surfactant surface tension influences alveolar capillary shape and oxygenation. Ikegami M, et al. Am J Respir Cell Mol Biol, 2009 Oct. PMID 19202005, Free PMC Article
    2. Use of knockout mice to study surfactant protein structure and function. Weaver TE, et al. Biol Neonate, 1999 Jun. PMID 10393388
    3. Surfactant protein B corrects oxygen-induced pulmonary dysfunction in heterozygous surfactant protein B-deficient mice. Tokieda K, et al. Pediatr Res, 1999 Dec. PMID 10590028
    4. Proteomic analysis reveals down-regulation of surfactant protein B in murine type II pneumocytes infected with influenza A virus. Kebaabetswe LP, et al. Virology, 2015 Sep. PMID 25965799, Free PMC Article
    5. Intersubunit disulfide bridge is not required for the protective role of SP-B against lung inflammation. Ikegami M, et al. J Appl Physiol (1985), 2002 Aug. PMID 12133857

    See all (209) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Umbilical Cord-derived Mesenchymal Stem Cells with Surfactant Protein B Alleviates Inflammatory Response in Acute Respiratory Distress Syndrome by Regulating Macrophage Polarization.
      Title: Umbilical Cord-derived Mesenchymal Stem Cells with Surfactant Protein B Alleviates Inflammatory Response in Acute Respiratory Distress Syndrome by Regulating Macrophage Polarization.
    2. Mechanism of Lamellar Body Formation by Lung Surfactant Protein B.
      Title: Mechanism of Lamellar Body Formation by Lung Surfactant Protein B.
    3. This study investigated the relationship between abnormal alveolar micromechanics, alveolar epithelial injury, intra-alveolar fluid properties and remodeling in the conditional surfactant protein B (SP-B) knockout mouse model.
      Title: Surfactant Protein B Deficiency Induced High Surface Tension: Relationship between Alveolar Micromechanics, Alveolar Fluid Properties and Alveolar Epithelial Cell Injury.
    4. EMC3 was essential for the processing and routing of surfactant proteins, SP-B and SP-C, and the biogenesis of the phospholipid transport protein ABCA3.
      Title: EMC3 coordinates surfactant protein and lipid homeostasis required for respiration.
    5. In triple KO mice, the HO-induced lung injury was associated with decreased surfactant protein (SP) A and SPC but not SPB and SPD expression.
      Title: Hyperoxia treatment of TREK-1/TREK-2/TRAAK-deficient mice is associated with a reduction in surfactant proteins.
    6. Surfactant protein B suppresses lung cancer progression by inhibiting secretory phospholipase A2 activity and arachidonic acid production.
      Title: Surfactant Protein B Suppresses Lung Cancer Progression by Inhibiting Secretory Phospholipase A2 Activity and Arachidonic Acid Production.
    7. These data provided a plausible mechanism linking maternal vitamin D deficiency with altered postnatal lung function.
      Title: Identification of vitamin D sensitive pathways during lung development.
    8. Surfactant protein B had decreased levels in influenza A virus PR8-infected cells, which was confirmed by immunoblotting and immunofluorescence assays.
      Title: Proteomic analysis reveals down-regulation of surfactant protein B in murine type II pneumocytes infected with influenza A virus.
    9. macrophages participate in the repression of SFTPB expression by LPS, and that macrophage-released cytokines (including TNF) regulate the transcription factor CEBPB
      Title: LPS-treated macrophage cytokines repress surfactant protein-B in lung epithelial cells.
    10. Tuberous sclerosis complex 1 contributes to the regulation of synthesis of surfactant proteins A and B.
      Title: Deficiency in pulmonary surfactant proteins in mice with fatty acid binding protein 4-Cre-mediated knockout of the tuberous sclerosis complex 1 gene.
    Submit: New GeneRIF Correction See all GeneRIFs (29)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in respiratory gaseous exchange by respiratory system IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sphingolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in alveolar lamellar body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in alveolar lamellar body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in multivesicular body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in multivesicular body ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pulmonary surfactant-associated protein B
    Names
    pulmonary surfactant-associated proteolipid SPL(Phe)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282071.3 → NP_001269000.1  pulmonary surfactant-associated protein B isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC116115, FO681326
      Consensus CDS
      CCDS71775.1
      UniProtKB/TrEMBL
      S4R2L6
      Related
      ENSMUSP00000138695.2, ENSMUST00000183018.8
      Conserved Domains (4) summary
      smart00741
      Location:66 → 142
      SapB; Saposin (B) Domains
      pfam03489
      Location:111 → 142
      SapB_2; Saposin-like type B, region 2
      pfam05184
      Location:68 → 102
      SapB_1; Saposin-like type B, region 1
      cl02494
      Location:27 → 60
      SapA; Saposin A-type domain

    2. NM_147779.3 → NP_680088.1  pulmonary surfactant-associated protein B isoform 1 precursor

      See identical proteins and their annotated locations for NP_680088.1

      Status: VALIDATED

      Source sequence(s)
      AC116115, FO681326
      UniProtKB/Swiss-Prot
      P50405
      Related
      ENSMUSP00000138204.4, ENSMUST00000182014.10
      Conserved Domains (4) summary
      smart00741
      Location:66 → 142
      SapB; Saposin (B) Domains
      pfam03489
      Location:111 → 142
      SapB_2; Saposin-like type B, region 2
      pfam05184
      Location:68 → 102
      SapB_1; Saposin-like type B, region 1
      cl02494
      Location:27 → 60
      SapA; Saposin A-type domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      72281594..72291354
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50405.1 GenPept UniProtKB/Swiss-Prot:P50405

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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