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    Adam29 a disintegrin and metallopeptidase domain 29 [ Mus musculus (house mouse) ]

    Gene ID: 244486, updated on 9-Dec-2024

    Summary

    Official Symbol
    Adam29provided by MGI
    Official Full Name
    a disintegrin and metallopeptidase domain 29provided by MGI
    Primary source
    MGI:MGI:2676326
    See related
    Ensembl:ENSMUSG00000046258 AllianceGenome:MGI:2676326
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. [provided by RefSeq, May 2016]
    Expression
    Restricted expression toward testis adult (RPKM 7.0) See more
    Orthologs
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    Genomic context

    See Adam29 in Genome Data Viewer
    Location:
    8 B2; 8 29.68 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (56323947..56359999, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (55870912..55906964, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36453 Neighboring gene STARR-seq mESC enhancer starr_21507 Neighboring gene STARR-seq mESC enhancer starr_21508 Neighboring gene STARR-seq mESC enhancer starr_21509 Neighboring gene STARR-seq mESC enhancer starr_21510 Neighboring gene methyltransferase like 13 pseudogene Neighboring gene STARR-seq mESC enhancer starr_21511 Neighboring gene glycine receptor, alpha 3 subunit Neighboring gene ribosomal protein S7 pseudogene Neighboring gene STARR-seq mESC enhancer starr_21512 Neighboring gene STARR-seq mESC enhancer starr_21513 Neighboring gene STARR-seq mESC enhancer starr_21514 Neighboring gene STARR-seq mESC enhancer starr_21515 Neighboring gene STARR-seq mESC enhancer starr_21516 Neighboring gene hydroxyprostaglandin dehydrogenase 15 (NAD)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metalloendopeptidase activity  
    enables metalloendopeptidase activity  
    enables molecular_function  
    Process Evidence Code Pubs
    involved_in male gonad development  
    involved_in proteolysis  
    involved_in proteolysis  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane  
    located_in external side of plasma membrane PubMed 
    is_active_in plasma membrane  
    is_active_in sperm head plasma membrane  
    located_in sperm head plasma membrane PubMed 

    General protein information

    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 29
    Names
    a disintegrin and metalloprotease domain 29
    a disintegrin and metalloproteinase domain 29

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175939.3NP_787953.2  disintegrin and metalloproteinase domain-containing protein 29 preproprotein

      See identical proteins and their annotated locations for NP_787953.2

      Status: VALIDATED

      Source sequence(s)
      AC158951, BB614467
      Consensus CDS
      CCDS22311.1
      UniProtKB/Swiss-Prot
      Q811Q4
      UniProtKB/TrEMBL
      G3X9B5
      Related
      ENSMUSP00000054292.5, ENSMUST00000053441.5
      Conserved Domains (5) summary
      smart00608
      Location:489624
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:205391
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:412484
      Disintegrin; Disintegrin
      pfam01421
      Location:205391
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:58158
      Pep_M12B_propep; Reprolysin family propeptide

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      56323947..56359999 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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