Trim58 tripartite motif-containing 58 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trim58provided by MGI
Official Full Name: tripartite motif-containing 58provided by MGI
Primary source: MGI:MGI:2684862
See related: Ensembl:ENSMUSG00000037124 AllianceGenome:MGI:2684862
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm16; Gm1783
Summary: Enables dynein heavy chain binding activity; dynein intermediate chain binding activity; and ubiquitin protein ligase activity. Involved in several processes, including positive regulation of erythrocyte enucleation; protein ubiquitination; and regulation of nuclear migration along microtubule. Predicted to be active in cytosol and nucleoplasm. Orthologous to human TRIM58 (tripartite motif containing 58). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in liver E14.5 (RPKM 8.4), liver E14 (RPKM 6.8) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B1.3; 11 36.23 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (58531232..58543277)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (58640465..58652404)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Trim58 binds dynein, promotes its proteasomal degradation and regulates terminal erythropoiesis.
Title: Trim58 degrades Dynein and regulates terminal erythropoiesis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables dynein heavy chain binding	IDA Inferred from Direct Assay more info	PubMed
enables dynein intermediate chain binding	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of erythrocyte enucleation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autoubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein polyubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of nuclear migration along microtubule	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase TRIM58

Names: RING-type E3 ubiquitin transferase TRIM58; tripartite motif-containing protein 58

NP_001034136.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039047.2 → NP_001034136.1 E3 ubiquitin-protein ligase TRIM58

See identical proteins and their annotated locations for NP_001034136.1

Status: VALIDATED

Source sequence(s)

AL645802

Consensus CDS

CCDS24738.1

UniProtKB/Swiss-Prot

Q5NCC9

UniProtKB/TrEMBL

B9EK29

Related

ENSMUSP00000074594.5, ENSMUST00000075084.5

Conserved Domains (3) summary

smart00336
Location:90 → 131

BBOX; B-Box-type zinc finger

pfam15227
Location:15 → 58

zf-C3HC4_4; zinc finger of C3HC4-type, RING

cd15816
Location:291 → 458

SPRY_PRY_TRIM58; PRY/SPRY domain in tripartite motif-binding protein 58 (TRIM58), also known as BIA2