Trip11 thyroid hormone receptor interactor 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trip11provided by MGI
Official Full Name: thyroid hormone receptor interactor 11provided by MGI
Primary source: MGI:MGI:1924393
See related: Ensembl:ENSMUSG00000021188 AllianceGenome:MGI:1924393
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TRIP230; GMAP-210; 2610511G22Rik; 3110031G15Rik; 6030460N08Rik
Summary: Predicted to enable small GTPase binding activity. Acts upstream of or within several processes, including chondrocyte differentiation involved in endochondral bone morphogenesis; inner ear receptor cell stereocilium organization; and ventricular septum development. Located in acrosomal membrane and cis-Golgi network. Is expressed in cranium. Used to study achondrogenesis type IA. Human ortholog(s) of this gene implicated in achondrogenesis type IA. Orthologous to human TRIP11 (thyroid hormone receptor interactor 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 5.0), cerebellum adult (RPKM 3.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 E; 12 51.3 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (101800304..101879463, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (101834045..101913171, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Disruption of Trip11 in cranial neural crest cells is associated with increased ER and Golgi stress contributing to skull defects in mice.
Title: Disruption of Trip11 in cranial neural crest cells is associated with increased ER and Golgi stress contributing to skull defects in mice.
GMAP210 is essential for acrosome biogenesis, normal mitochondrial sheath formation, and male fertility, and it determines expression levels and acrosomal localization of IFT20 and other acrosomal proteins.
Title: Abnormal fertility, acrosome formation, IFT20 expression and localization in conditional Gmap210 knockout mice.
Data show that IFT88 is present in the Golgi of spermatids, that the microtubule-associated golgin GMAP210 and IFT88 participate in acrosome, HTCA, and tail biogenesis.
Title: GMAP210 and IFT88 are present in the spermatid golgi apparatus and participate in the development of the acrosome-acroplaxome complex, head-tail coupling apparatus and tail.
mice with lethal skeletal dysplasia had a nonsense mutation in the thyroid hormone receptor interactor 11 gene (Trip11), which encodes the Golgi microtubule-associated protein 210 (GMAP-210)
Title: Lethal skeletal dysplasia in mice and humans lacking the golgin GMAP-210.
GMAP210 and IFT20 function together at the Golgi in the sorting of proteins destined for the ciliary membrane.
Title: The Golgin GMAP210/TRIP11 anchors IFT20 to the Golgi complex.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (1)
Gene trapped (1) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Trip11 (e-PCR), detects polymorphism
- UniSTS:547167

D1S3690 (e-PCR)
- UniSTS:474268

AI450776 (e-PCR)
- UniSTS:160245

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Golgi organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Golgi organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Golgi ribbon formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bone development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cartilage development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chondrocyte differentiation involved in endochondral bone morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inner ear receptor cell stereocilium organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein glycosylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ventricular septum development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle tethering to Golgi	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in acrosomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cis-Golgi network	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum-Golgi intermediate compartment	ISO Inferred from Sequence Orthology more info
located_in inner acrosomal membrane	ISO Inferred from Sequence Orthology more info
located_in outer acrosomal membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: thyroid receptor-interacting protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028446.1 → NP_082722.1 thyroid receptor-interacting protein 11

Status: VALIDATED

Source sequence(s)

AC121965

Consensus CDS

CCDS49143.1

UniProtKB/TrEMBL

B2RY51, E9Q512

Related

ENSMUSP00000021605.8, ENSMUST00000021605.14

Conserved Domains (2) summary

COG1196
Location:946 → 1768

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:226 → 1065

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

101800304..101879463 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006515382.4 → XP_006515445.1 thyroid receptor-interacting protein 11 isoform X1

UniProtKB/TrEMBL

B2RY51

Conserved Domains (2) summary

COG1196
Location:945 → 1767

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:225 → 1064

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_011243986.3 → XP_011242288.1 thyroid receptor-interacting protein 11 isoform X2

UniProtKB/TrEMBL

B2RY51

Conserved Domains (2) summary

COG1196
Location:882 → 1704

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:162 → 1001

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_036157159.1 → XP_036013052.1 thyroid receptor-interacting protein 11 isoform X3

UniProtKB/TrEMBL

H3BJG4

Conserved Domains (2) summary

COG1196
Location:10 → 764

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam10375
Location:1370 → 1415

GRAB; GRIP-related Arf-binding domain