Slc38a8 solute carrier family 38, member 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc38a8provided by MGI
Official Full Name: solute carrier family 38, member 8provided by MGI
Primary source: MGI:MGI:2685433
See related: Ensembl:ENSMUSG00000034224 AllianceGenome:MGI:2685433
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm587
Summary: Predicted to enable L-amino acid transmembrane transporter activity. Acts upstream of or within nervous system development; retinal pigment epithelium development; and visual perception. Predicted to be located in axon and cell cortex. Predicted to be active in membrane. Used to study foveal hypoplasia 2. Human ortholog(s) of this gene implicated in foveal hypoplasia 2. Orthologous to human SLC38A8 (solute carrier family 38 member 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 8 E1; 8 67.8 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (120206313..120228503, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (119479574..119501698, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Picornavirus infection enhances aspartate by the SLC38A8 transporter to promote viral replication.
Title: Picornavirus infection enhances aspartate by the SLC38A8 transporter to promote viral replication.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Gene trapped (1)

General gene information

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Markers

Slc38a8 (e-PCR), detects polymorphism
- UniSTS:547102

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in amino acid transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in amino acid transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within optic nerve development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retina development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retinal pigment epithelium development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within visual perception	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cell cortex	IEA Inferred from Electronic Annotation more info
is_active_in cellular_component	ND No biological Data available more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: solute carrier family 38 member 8

Names: amino acid transporter SLC38A8; putative sodium-coupled neutral amino acid transporter 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009950.2 → NP_001009950.1 solute carrier family 38 member 8

See identical proteins and their annotated locations for NP_001009950.1

Status: VALIDATED

Source sequence(s)

AC140672, AC166781

Consensus CDS

CCDS22706.1

UniProtKB/Swiss-Prot

Q5HZH7

Related

ENSMUSP00000038438.9, ENSMUST00000036748.15

Conserved Domains (2) summary

COG0814
Location:23 → 429

SdaC; Amino acid permease [Amino acid transport and metabolism]

cl00456
Location:23 → 421

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

120206313..120228503 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011248368.2 → XP_011246670.1 solute carrier family 38 member 8 isoform X1

See identical proteins and their annotated locations for XP_011246670.1

Conserved Domains (1) summary

cl00456
Location:1 → 322

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain