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    Zfp563 zinc finger protein 563 [ Mus musculus (house mouse) ]

    Gene ID: 240068, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp563provided by MGI
    Official Full Name
    zinc finger protein 563provided by MGI
    Primary source
    MGI:MGI:2677168
    See related
    Ensembl:ENSMUSG00000067424 AllianceGenome:MGI:2677168
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NTfin7; Zfp413; D130054H01
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system and genitourinary system. Orthologous to human ZNF563 (zinc finger protein 563). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E18 (RPKM 2.6), whole brain E14.5 (RPKM 2.1) and 23 other tissues See more
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    Genomic context

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    See Zfp563 in Genome Data Viewer
    Location:
    17 B1; 17 17.98 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (33308341..33340098)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (33089367..33110707)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 763 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:33170086-33170195 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:33170311-33170494 Neighboring gene STARR-seq mESC enhancer starr_42403 Neighboring gene PHD finger protein 8 like Neighboring gene STARR-positive B cell enhancer ABC_E4206 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:33226471-33226658 Neighboring gene STARR-seq mESC enhancer starr_42404 Neighboring gene microrchidia 2B Neighboring gene predicted gene, 52288 Neighboring gene predicted gene, 21062

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Gene content of the 750-kb critical region for mouse embryonic ectoderm lethal tcl-w5. Abe K, et al. Mamm Genome, 2004 Apr. PMID 15112104
    2. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    3. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 563
    Names
    Novel zinc finger protein
    zinc finger protein NTfin7
    zinc finger protein ZFP413

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024950.2 → NP_001020121.2  zinc finger protein 563

      See identical proteins and their annotated locations for NP_001020121.2

      Status: VALIDATED

      Source sequence(s)
      BB662414, BY329545, CAAA01126850
      Consensus CDS
      CCDS50063.1
      UniProtKB/TrEMBL
      B8JJZ9
      Related
      ENSMUSP00000118809.2, ENSMUST00000131722.9
      Conserved Domains (3) summary
      COG5048
      Location:167 → 328
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:311 → 331
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:3 → 44
      KRAB; KRAB box

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      33308341..33340098
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524255.5 → XP_006524318.1  zinc finger protein 563 isoform X1

      Conserved Domains (2) summary
      COG5048
      Location:189 → 350
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:333 → 353
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_006524256.3 → XP_006524319.1  zinc finger protein 563 isoform X2

      See identical proteins and their annotated locations for XP_006524319.1

      UniProtKB/TrEMBL
      B8JJZ9
      Conserved Domains (3) summary
      COG5048
      Location:167 → 328
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:311 → 331
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:3 → 44
      KRAB; KRAB box

    3. XM_036160604.1 → XP_036016497.1  zinc finger protein 563 isoform X3

      Conserved Domains (2) summary
      COG5048
      Location:135 → 296
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:279 → 299
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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