Slc9a2 solute carrier family 9 (sodium/hydrogen exchanger), member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc9a2provided by MGI
Official Full Name: solute carrier family 9 (sodium/hydrogen exchanger), member 2provided by MGI
Primary source: MGI:MGI:105075
See related: Ensembl:ENSMUSG00000026062 AllianceGenome:MGI:105075
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NHE2; NHE-2; 2210416H12Rik; 4932415O19Rik
Summary: Enables sodium:proton antiporter activity. Involved in epithelial cell differentiation and regulation of intracellular pH. Acts upstream of or within protein localization; regulation of pH; and sodium ion transport. Located in apical plasma membrane. Is expressed in genitourinary system and skeleton. Orthologous to human SLC9A2 (solute carrier family 9 member A2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in colon adult (RPKM 88.7), small intestine adult (RPKM 52.2) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 B; 1 19.66 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (40720872..40808045)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (40681712..40768885)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sodium/hydrogen-exchanger-2 modulates colonocyte lineage differentiation.
Title: Sodium/hydrogen-exchanger-2 modulates colonocyte lineage differentiation.
Expression of solute carrier family 40 (iron-regulated transporter) member 1 (Slc40a1) within the mammary gland can mediate the effect of milk mineral concentration quantitative trait loci 9 (Mmcq9) on milk iron concentration.
Title: In silico mapping of quantitative trait loci (QTL) regulating the milk ionome in mice identifies a milk iron locus on chromosome 1.
functional NHE2, but not NHE1, is essential for mouse gastric epithelial restitution and TFFs activate epithelial repair via NHE2
Title: Trefoil factor 2 requires Na/H exchanger 2 activity to enhance mouse gastric epithelial repair.
Mucosa from NHE2(-/-) mice displayed a shift of occludin and claudin-1 expression to the Triton-X-soluble membrane fractions and showed disruption of occludin and claudin-1 localization patterns following injury.
Title: Mice lacking the Na+/H+ exchanger 2 have impaired recovery of intestinal barrier function.
Renal tissue renin activity and plasma renin concentration were elevated three- and twofold, respectively, in NHE2 knckout mice.
Title: Increased renal renin content in mice lacking the Na+/H+ exchanger NHE2.
Here, we show that NHE10 is highly expressed in OCs in response to receptor activator of nuclear factor-kappaB ligand signaling and is required for OC differentiation and survival.
Title: NHE10, an osteoclast-specific member of the Na+/H+ exchanger family, regulates osteoclast differentiation and survival [corrected].
thick ascending cells retain structural and functional properties of their in vivo thick ascending counterparts and express functional NHE2 protein in the apical membrane, which may be inhibited by nitric oxide
Title: Differentiated thick ascending limb (TAL) cultured cells derived from SV40 transgenic mice express functional apical NHE2 isoform: effect of nitric oxide.
This study demonstrated that constitutive absence of NHE2 results in a compensatory increase in a Na(+)-dependent, EIPA-sensitive acid extruder distinct from NHE1, NHE3, or SITS-sensitive transporters.
Title: NHE2 is the main apical NHE in mouse colonic crypts but an alternative Na+-dependent acid extrusion mechanism is upregulated in NHE2-null mice.
High NHE2 expression in crypts. Role for NHE2 in cryptal pH(i) and volume homeostasis.
Title: The Na+/H+ exchanger isoform 2 is the predominant NHE isoform in murine colonic crypts and its lack causes NHE3 upregulation.
Bicarbonate reabsorption in the distal tubule of mice with genetic knockouts at NHE2 or NHE3.
Title: NHE2-mediated bicarbonate reabsorption in the distal tubule of NHE3 null mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc9a2 (e-PCR), detects polymorphism
- UniSTS:144435

AV333884 (e-PCR)
- UniSTS:178378

Slc9a2 (e-PCR), detects polymorphism
- UniSTS:546027

D9M1Mit172 (e-PCR)
- UniSTS:128511

D1Mit172 (e-PCR), detects polymorphism
- UniSTS:128511

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables potassium:proton antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:proton antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:proton antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables sodium:proton antiporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in epithelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of intracellular pH	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of intracellular pH	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of pH	IDA Inferred from Direct Assay more info	PubMed
involved_in sodium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sodium ion transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in brush border	TAS Traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: sodium/hydrogen exchanger 2

Names: Na(+)/H(+) exchanger 2; sodium/hydrogen exchanger; solute carrier family 9 member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033289.2 → NP_001028461.2 sodium/hydrogen exchanger 2 precursor

See identical proteins and their annotated locations for NP_001028461.2

Status: PROVISIONAL

Source sequence(s)

BC103685

Consensus CDS

CCDS14914.1

UniProtKB/Swiss-Prot

Q3ZAS0

Related

ENSMUSP00000027231.8, ENSMUST00000027231.13

Conserved Domains (3) summary

TIGR00840
Location:75 → 631

b_cpa1; sodium/hydrogen exchanger 3

pfam00999
Location:85 → 485

Na_H_Exchanger; Sodium/hydrogen exchanger family

pfam16644
Location:579 → 685

NEXCaM_BD; Regulatory region of Na+/H+ exchanger NHE binds to calmodulin