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    Elk4 ELK4, member of ETS oncogene family [ Mus musculus (house mouse) ]

    Gene ID: 13714, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Elk4provided by MGI
    Official Full Name
    ELK4, member of ETS oncogene familyprovided by MGI
    Primary source
    MGI:MGI:102853
    See related
    Ensembl:ENSMUSG00000026436 AllianceGenome:MGI:102853
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sap1; SAP-1; 2310011G17Rik; A130026I01Rik
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Predicted to be involved in cell differentiation; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; and retina. Orthologous to human ELK4 (ETS transcription factor ELK4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 13.6), spleen adult (RPKM 6.7) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Elk4 in Genome Data Viewer
    Location:
    1 E4; 1 57.24 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (131935129..131954186)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (132007577..132026448)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02229 Neighboring gene nuclear casein kinase and cyclin-dependent kinase substrate 1 Neighboring gene solute carrier family 45, member 3 Neighboring gene STARR-positive B cell enhancer mm9_chr1:133879500-133879800 Neighboring gene STARR-positive B cell enhancer ABC_E5800 Neighboring gene STARR-positive B cell enhancer ABC_E5801 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:133904735-133904947 Neighboring gene STARR-positive B cell enhancer ABC_E10036 Neighboring gene STARR-positive B cell enhancer ABC_E11086 Neighboring gene STARR-positive B cell enhancer ABC_E5802 Neighboring gene major facilitator superfamily domain containing 4A Neighboring gene RIKEN cDNA 4833413N01 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:133998691-133998892 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:133998935-133999044 Neighboring gene predicted gene, 37120

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ternary complex factor SAP-1 is required for Erk-mediated thymocyte positive selection. Costello PS, et al. Nat Immunol, 2004 Mar. PMID 14770179
    2. ELK4 ameliorates cognitive impairment and neuroinflammation induced by obstructive sleep apnea. Yang H, et al. Brain Res Bull, 2024 Oct 1. PMID 39173777
    3. Raf signaling but not the ERK effector SAP-1 is required for regulatory T cell development. Willoughby JE, et al. J Immunol, 2007 Nov 15. PMID 17982074, Free PMC Article
    4. CircELK4 Contributes to Lupus Nephritis by Acting as a miR-27b-3p Sponge to Regulate STING/IRF3/IFN-I Signaling. Xu ZQ, et al. Inflammation, 2021 Oct. PMID 34091806
    5. ERK Signaling Controls Innate-like CD8(+) T Cell Differentiation via the ELK4 (SAP-1) and ELK1 Transcription Factors. Maurice D, et al. J Immunol, 2018 Sep 15. PMID 30068599, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ELK4 ameliorates cognitive impairment and neuroinflammation induced by obstructive sleep apnea.
      Title: ELK4 ameliorates cognitive impairment and neuroinflammation induced by obstructive sleep apnea.
    2. CircELK4 Contributes to Lupus Nephritis by Acting as a miR-27b-3p Sponge to Regulate STING/IRF3/IFN-I Signaling.
      Title: CircELK4 Contributes to Lupus Nephritis by Acting as a miR-27b-3p Sponge to Regulate STING/IRF3/IFN-I Signaling.
    3. These data establish that low-level ERK signaling through ELK4 (and ELK1) promotes innate-like alphabeta CD8(+) T cell differentiation, tuning conventional versus innate-like development.
      Title: ERK Signaling Controls Innate-like CD8(+) T Cell Differentiation via the ELK4 (SAP-1) and ELK1 Transcription Factors.
    4. Dok-4 can target Elk-4 activity through multiple mechanisms, including binding of the transactivation domain, nuclear exclusion and protein destabilization.
      Title: Binding and inhibition of the ternary complex factor Elk-4/Sap1 by the adapter protein Dok-4.
    5. MKL1/2 and ELK4 co-regulate distinct serum response factor (SRF) transcription programs in macrophages.
      Title: MKL1/2 and ELK4 co-regulate distinct serum response factor (SRF) transcription programs in macrophages.
    6. Data show that Elk-1 and Net do not contribute significantly to thymocyte development in the presence of SAP-1.
      Title: Ternary complex factors SAP-1 and Elk-1, but not net, are functionally equivalent in thymocyte development.
    7. T cell positive selection, and ERK signaling to SAP-1 is not required for the suppressive activity of T(reg) cells.
      Title: Raf signaling but not the ERK effector SAP-1 is required for regulatory T cell development.
    8. SAP-1 is required for Erk-mediated transcriptional events in thymocyte development.
      Title: Ternary complex factor SAP-1 is required for Erk-mediated thymocyte positive selection.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ETS domain-containing protein Elk-4
    Names
    SRF accessory protein 1
    serum response factor accessory protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001376954.1 → NP_001363883.1  ETS domain-containing protein Elk-4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC107837
      UniProtKB/Swiss-Prot
      A6H693, P41158
      Conserved Domains (2) summary
      smart00413
      Location:17 → 88
      ETS; erythroblast transformation specific domain
      PHA03247
      Location:170 → 349
      PHA03247; large tegument protein UL36; Provisional

    2. NM_001376955.1 → NP_001363884.1  ETS domain-containing protein Elk-4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC107837
      UniProtKB/Swiss-Prot
      A6H693, P41158
      Conserved Domains (2) summary
      smart00413
      Location:17 → 88
      ETS; erythroblast transformation specific domain
      PHA03247
      Location:170 → 349
      PHA03247; large tegument protein UL36; Provisional

    3. NM_001376956.1 → NP_001363885.1  ETS domain-containing protein Elk-4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC107837
      UniProtKB/Swiss-Prot
      A6H693, P41158
      Conserved Domains (2) summary
      smart00413
      Location:17 → 88
      ETS; erythroblast transformation specific domain
      PHA03247
      Location:170 → 349
      PHA03247; large tegument protein UL36; Provisional

    4. NM_001376957.1 → NP_001363886.1  ETS domain-containing protein Elk-4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC107837
      UniProtKB/Swiss-Prot
      A6H693, P41158
      Related
      ENSMUSP00000027696.4, ENSMUST00000027696.10
      Conserved Domains (2) summary
      smart00413
      Location:17 → 88
      ETS; erythroblast transformation specific domain
      PHA03247
      Location:170 → 349
      PHA03247; large tegument protein UL36; Provisional

    5. NM_001376958.1 → NP_001363887.1  ETS domain-containing protein Elk-4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC107837
      UniProtKB/Swiss-Prot
      A6H693, P41158
      Conserved Domains (2) summary
      smart00413
      Location:17 → 88
      ETS; erythroblast transformation specific domain
      PHA03247
      Location:170 → 349
      PHA03247; large tegument protein UL36; Provisional

    6. NM_001376959.1 → NP_001363888.1  ETS domain-containing protein Elk-4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC107837
      Conserved Domains (1) summary
      smart00413
      Location:17 → 69
      ETS; erythroblast transformation specific domain

    7. NM_007923.3 → NP_031949.2  ETS domain-containing protein Elk-4 isoform 1

      See identical proteins and their annotated locations for NP_031949.2

      Status: VALIDATED

      Source sequence(s)
      AC107837
      Consensus CDS
      CCDS35704.1
      UniProtKB/Swiss-Prot
      A6H693, P41158
      Related
      ENSMUSP00000083743.6, ENSMUST00000086556.12
      Conserved Domains (2) summary
      smart00413
      Location:17 → 88
      ETS; erythroblast transformation specific domain
      PHA03247
      Location:170 → 349
      PHA03247; large tegument protein UL36; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      131935129..131954186
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158973.1 → XP_036014866.1  ETS domain-containing protein Elk-4 isoform X1

      UniProtKB/Swiss-Prot
      A6H693, P41158
      Conserved Domains (2) summary
      smart00413
      Location:17 → 88
      ETS; erythroblast transformation specific domain
      PHA03247
      Location:170 → 349
      PHA03247; large tegument protein UL36; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P41158.2 GenPept UniProtKB/Swiss-Prot:P41158

    Gene LinkOut

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