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    Nup58 nucleoporin 58 [ Mus musculus (house mouse) ]

    Gene ID: 71844, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Nup58provided by MGI
    Official Full Name
    nucleoporin 58provided by MGI
    Primary source
    MGI:MGI:1919094
    See related
    Ensembl:ENSMUSG00000114797 AllianceGenome:MGI:1919094
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nupl1; mKIAA0410; 1700017F11Rik
    Summary
    Predicted to enable identical protein binding activity and nuclear localization sequence binding activity. Predicted to be a structural constituent of nuclear pore. Predicted to be involved in nucleocytoplasmic transport and regulation of protein import into nucleus. Predicted to be located in nuclear envelope. Predicted to be part of nuclear pore. Is expressed in testis. Orthologous to human NUP58 (nucleoporin 58). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 28.8), CNS E11.5 (RPKM 13.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nup58 in Genome Data Viewer
    Location:
    14 D1; 14 31.62 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (60442733..60488951, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (60205284..60251479, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33582 Neighboring gene predicted gene, 57492 Neighboring gene STARR-seq mESC enhancer starr_36855 Neighboring gene microRNA 719 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:60870359-60870542 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:60883833-60884016 Neighboring gene myotubularin related protein 6 Neighboring gene predicted gene, 34874 Neighboring gene STARR-seq mESC enhancer starr_36856 Neighboring gene STARR-seq mESC enhancer starr_36857 Neighboring gene APC membrane recruitment 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Gene- and Species-Specific Hox mRNA Translation by Ribosome Expansion Segments. Leppek K, et al. Mol Cell, 2020 Dec 17. PMID 33202249, Free PMC Article
    2. Peering through the pore: nuclear pore complex structure, assembly, and function. Suntharalingam M, et al. Dev Cell, 2003 Jun. PMID 12791264
    3. Bioinformatics and cellular signaling. Papin J, et al. Curr Opin Biotechnol, 2004 Feb. PMID 15102471
    4. Comprehensive Proteomic Analysis of PGC7-Interacting Proteins. Liu H, et al. J Proteome Res, 2017 Sep 1. PMID 28712289
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear localization sequence binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear localization sequence binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleocytoplasmic transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleocytoplasmic transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear pore NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nucleoporin p58/p45
    Names
    58 kDa nucleoporin
    nucleoporin like 1
    nucleoporin-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362439.1 → NP_001349368.1  nucleoporin p58/p45 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC131687, AC166113, AK006062, AK086412
      Consensus CDS
      CCDS88679.1
      UniProtKB/TrEMBL
      Q3UZQ6
      Related
      ENSMUSP00000153625.2, ENSMUST00000225111.2
      Conserved Domains (1) summary
      cl25599
      Location:3 → 537
      Nucleoporin_FG2; Nucleoporin FG repeated region

    2. NM_001362440.1 → NP_001349369.1  nucleoporin p58/p45 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC131687, AC166113, AK006062, AK078279
      Consensus CDS
      CCDS88680.1
      UniProtKB/TrEMBL
      Q3UZQ6
      Related
      ENSMUSP00000153117.2, ENSMUST00000225311.2
      Conserved Domains (1) summary
      cl25599
      Location:3 → 541
      Nucleoporin_FG2; Nucleoporin FG repeated region

    3. NM_170591.2 → NP_733479.1  nucleoporin p58/p45 isoform 1

      See identical proteins and their annotated locations for NP_733479.1

      Status: VALIDATED

      Source sequence(s)
      AC166113, AK040206, AK139895, AK146477, CJ220943, EH096615
      Consensus CDS
      CCDS27175.1
      UniProtKB/Swiss-Prot
      Q3UJF4, Q8BUA7, Q8BVG7, Q8C0W3, Q8R332
      UniProtKB/TrEMBL
      Q3UZQ6
      Related
      ENSMUSP00000038716.7, ENSMUST00000041905.8
      Conserved Domains (2) summary
      pfam02321
      Location:278 → 424
      OEP; Outer membrane efflux protein
      pfam15967
      Location:22 → 587
      Nucleoporin_FG2; Nucleoporin FG repeated region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      60442733..60488951 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158853.1 → XP_036014746.1  nucleoporin p58/p45 isoform X1

      UniProtKB/TrEMBL
      Q3UZQ6
      Conserved Domains (1) summary
      pfam15967
      Location:2 → 531
      Nucleoporin_FG2; Nucleoporin FG repeated region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R332.1 GenPept UniProtKB/Swiss-Prot:Q8R332

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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