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    Lrrc74b leucine rich repeat containing 74B [ Mus musculus (house mouse) ]

    Gene ID: 74685, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Lrrc74bprovided by MGI
    Official Full Name
    leucine rich repeat containing 74Bprovided by MGI
    Primary source
    MGI:MGI:1921935
    See related
    Ensembl:ENSMUSG00000022759 AllianceGenome:MGI:1921935
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mCG12354; mCP17390; 4930451C15Rik
    Summary
    Orthologous to human LRRC74B (leucine rich repeat containing 74B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in ovary adult (RPKM 2.4), genital fat pad adult (RPKM 1.9) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lrrc74b in Genome Data Viewer
    Location:
    16 A3; 16 10.87 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (17362329..17379159, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (17544465..17561328, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene leucine-zipper-like transcriptional regulator, 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:17531169-17531278 Neighboring gene THAP domain containing 7 Neighboring gene STARR-positive B cell enhancer ABC_E10890 Neighboring gene STARR-seq mESC enhancer starr_40257 Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 6 Neighboring gene solute carrier family 7 (cationic amino acid transporter, y+ system), member 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Risk of meningomyelocele mediated by the common 22q11.2 deletion. Vong KI, et al. Science, 2024 May 3. PMID 38696583
    2. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
    3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 74B
    Names
    leucine-rich repeat-containing protein LOC400891 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145435.1 → NP_001138907.1  leucine-rich repeat-containing protein 74B isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment near the C-terminus, compared to isoform 1.
      Source sequence(s)
      AC113006, AK161226, BB634732
      Consensus CDS
      CCDS49777.1
      UniProtKB/Swiss-Prot
      Q14BP6
      Related
      ENSMUSP00000023442.7, ENSMUST00000023442.13
      Conserved Domains (3) summary
      cd00116
      Location:56 → 340
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:159 → 190
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:189 → 257
      LRR_8; Leucine rich repeat

    2. NM_029053.3 → NP_083329.2  leucine-rich repeat-containing protein 74B isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer variant and encodes the longer isoform (1).
      Source sequence(s)
      AC113006, AK161226, BB634732, BC115678
      Consensus CDS
      CCDS28006.2
      UniProtKB/Swiss-Prot
      Q14BP6, Q3UPS2, Q8BYL7
      Related
      ENSMUSP00000097699.4, ENSMUST00000100123.10
      Conserved Domains (3) summary
      sd00031
      Location:303 → 315
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:159 → 190
      LRR_RI; leucine-rich repeat [structural motif]
      cl39015
      Location:56 → 353
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      17362329..17379159 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522677.4 → XP_006522740.1  leucine-rich repeat-containing protein 74B isoform X2

      Related
      ENSMUSP00000155867.2, ENSMUST00000232637.2
      Conserved Domains (3) summary
      sd00031
      Location:303 → 315
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:159 → 190
      LRR_RI; leucine-rich repeat [structural motif]
      cl39015
      Location:56 → 339
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    2. XM_011246037.3 → XP_011244339.1  leucine-rich repeat-containing protein 74B isoform X1

      Conserved Domains (3) summary
      sd00031
      Location:303 → 315
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:159 → 190
      LRR_RI; leucine-rich repeat [structural motif]
      cl39015
      Location:56 → 339
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    3. XM_036160173.1 → XP_036016066.1  leucine-rich repeat-containing protein 74B isoform X2

      Conserved Domains (3) summary
      sd00031
      Location:303 → 315
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:159 → 190
      LRR_RI; leucine-rich repeat [structural motif]
      cl39015
      Location:56 → 339
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    RNA

    1. XR_875856.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14BP6.1 GenPept UniProtKB/Swiss-Prot:Q14BP6

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