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    Card14 caspase recruitment domain family, member 14 [ Mus musculus (house mouse) ]

    Gene ID: 170720, updated on 27-Nov-2024

    Summary

    Official Symbol
    Card14provided by MGI
    Official Full Name
    caspase recruitment domain family, member 14provided by MGI
    Primary source
    MGI:MGI:2386258
    See related
    Ensembl:ENSMUSG00000013483 AllianceGenome:MGI:2386258
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bimp2; CARMA2
    Summary
    Predicted to enable CARD domain binding activity. Predicted to be involved in several processes, including positive regulation of NF-kappaB transcription factor activity; positive regulation of canonical NF-kappaB signal transduction; and tumor necrosis factor-mediated signaling pathway. Predicted to be located in aggresome and cytosol. Is expressed in gut; nose; and vibrissa. Used to study psoriasis 2. Human ortholog(s) of this gene implicated in pityriasis rubra pilaris and psoriasis 2. Orthologous to human CARD14 (caspase recruitment domain family member 14). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in colon adult (RPKM 7.9), large intestine adult (RPKM 5.4) and 19 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Card14 in Genome Data Viewer
    Location:
    11 E2; 11 83.36 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (119197923..119236205)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (119307093..119345379)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene glucosidase, alpha, acid Neighboring gene STARR-positive B cell enhancer ABC_E7111 Neighboring gene predicted gene, 39483 Neighboring gene eukaryotic translation initiation factor 4A3 Neighboring gene solute carrier family 26, member 11 Neighboring gene N-sulfoglucosamine sulfohydrolase (sulfamidase) Neighboring gene STARR-seq mESC enhancer starr_31317 Neighboring gene microRNA 1932 Neighboring gene ring finger protein 213

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables CARD domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables CARD domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in aggresome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in aggresome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    caspase recruitment domain-containing protein 14
    Names
    bcl10-interacting MAGUK protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130886.4NP_570956.1  caspase recruitment domain-containing protein 14

      See identical proteins and their annotated locations for NP_570956.1

      Status: VALIDATED

      Source sequence(s)
      AL645911
      Consensus CDS
      CCDS25715.1
      UniProtKB/Swiss-Prot
      Q99KF0
      Related
      ENSMUSP00000101857.2, ENSMUST00000106250.8
      Conserved Domains (8) summary
      cd00992
      Location:580652
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00261
      Location:120364
      Tropomyosin; Tropomyosin
      pfam15898
      Location:205275
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      cd16269
      Location:374385
      GBP_C; coiled coil [structural motif]
      cl14633
      Location:19104
      DD; Death Domain Superfamily of protein-protein interaction domains
      cl17036
      Location:677738
      SH3; Src Homology 3 domain superfamily
      cl17190
      Location:854978
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
      cl20817
      Location:282407
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      119197923..119236205
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532369.4XP_006532432.1  caspase recruitment domain-containing protein 14 isoform X1

      See identical proteins and their annotated locations for XP_006532432.1

      Conserved Domains (5) summary
      COG1196
      Location:132410
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00992
      Location:587659
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl14633
      Location:19104
      DD; Death Domain Superfamily of protein-protein interaction domains
      cl17036
      Location:684745
      SH3; Src Homology 3 domain superfamily
      cl17190
      Location:8841008
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    2. XM_006532379.5XP_006532442.1  caspase recruitment domain-containing protein 14 isoform X6

      Conserved Domains (4) summary
      COG1196
      Location:132410
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00992
      Location:587659
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl14633
      Location:19104
      DD; Death Domain Superfamily of protein-protein interaction domains
      cl17036
      Location:684745
      SH3; Src Homology 3 domain superfamily
    3. XM_006532378.5XP_006532441.1  caspase recruitment domain-containing protein 14 isoform X5

      Conserved Domains (4) summary
      COG1196
      Location:132410
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00992
      Location:587659
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl14633
      Location:19104
      DD; Death Domain Superfamily of protein-protein interaction domains
      cl17036
      Location:684745
      SH3; Src Homology 3 domain superfamily
    4. XM_006532371.5XP_006532434.1  caspase recruitment domain-containing protein 14 isoform X1

      See identical proteins and their annotated locations for XP_006532434.1

      Conserved Domains (5) summary
      COG1196
      Location:132410
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00992
      Location:587659
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl14633
      Location:19104
      DD; Death Domain Superfamily of protein-protein interaction domains
      cl17036
      Location:684745
      SH3; Src Homology 3 domain superfamily
      cl17190
      Location:8841008
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    5. XM_006532366.4XP_006532429.1  caspase recruitment domain-containing protein 14 isoform X1

      See identical proteins and their annotated locations for XP_006532429.1

      Conserved Domains (5) summary
      COG1196
      Location:132410
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00992
      Location:587659
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl14633
      Location:19104
      DD; Death Domain Superfamily of protein-protein interaction domains
      cl17036
      Location:684745
      SH3; Src Homology 3 domain superfamily
      cl17190
      Location:8841008
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    6. XM_006532373.3XP_006532436.1  caspase recruitment domain-containing protein 14 isoform X2

      Conserved Domains (5) summary
      COG1196
      Location:132410
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00992
      Location:580652
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl14633
      Location:19104
      DD; Death Domain Superfamily of protein-protein interaction domains
      cl17036
      Location:677738
      SH3; Src Homology 3 domain superfamily
      cl17190
      Location:8771001
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    7. XM_006532374.4XP_006532437.1  caspase recruitment domain-containing protein 14 isoform X3

      Conserved Domains (5) summary
      COG1196
      Location:132410
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00992
      Location:579651
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl14633
      Location:19104
      DD; Death Domain Superfamily of protein-protein interaction domains
      cl17036
      Location:676737
      SH3; Src Homology 3 domain superfamily
      cl17190
      Location:8761000
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    8. XM_006532370.5XP_006532433.1  caspase recruitment domain-containing protein 14 isoform X1

      See identical proteins and their annotated locations for XP_006532433.1

      Conserved Domains (5) summary
      COG1196
      Location:132410
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00992
      Location:587659
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl14633
      Location:19104
      DD; Death Domain Superfamily of protein-protein interaction domains
      cl17036
      Location:684745
      SH3; Src Homology 3 domain superfamily
      cl17190
      Location:8841008
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    9. XM_006532372.5XP_006532435.1  caspase recruitment domain-containing protein 14 isoform X1

      See identical proteins and their annotated locations for XP_006532435.1

      Conserved Domains (5) summary
      COG1196
      Location:132410
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00992
      Location:587659
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl14633
      Location:19104
      DD; Death Domain Superfamily of protein-protein interaction domains
      cl17036
      Location:684745
      SH3; Src Homology 3 domain superfamily
      cl17190
      Location:8841008
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    10. XM_006532367.5XP_006532430.1  caspase recruitment domain-containing protein 14 isoform X1

      See identical proteins and their annotated locations for XP_006532430.1

      Conserved Domains (5) summary
      COG1196
      Location:132410
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00992
      Location:587659
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl14633
      Location:19104
      DD; Death Domain Superfamily of protein-protein interaction domains
      cl17036
      Location:684745
      SH3; Src Homology 3 domain superfamily
      cl17190
      Location:8841008
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    11. XM_006532375.3XP_006532438.1  caspase recruitment domain-containing protein 14 isoform X4

      Conserved Domains (5) summary
      COG1196
      Location:132410
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00992
      Location:587659
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl14633
      Location:19104
      DD; Death Domain Superfamily of protein-protein interaction domains
      cl17036
      Location:684745
      SH3; Src Homology 3 domain superfamily
      cl17190
      Location:861985
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    12. XM_006532368.5XP_006532431.1  caspase recruitment domain-containing protein 14 isoform X1

      See identical proteins and their annotated locations for XP_006532431.1

      Conserved Domains (5) summary
      COG1196
      Location:132410
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00992
      Location:587659
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl14633
      Location:19104
      DD; Death Domain Superfamily of protein-protein interaction domains
      cl17036
      Location:684745
      SH3; Src Homology 3 domain superfamily
      cl17190
      Location:8841008
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...