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    METTL2A methyltransferase 2A, tRNA N3-cytidine [ Homo sapiens (human) ]

    Gene ID: 339175, updated on 10-Dec-2024

    Summary

    Official Symbol
    METTL2Aprovided by HGNC
    Official Full Name
    methyltransferase 2A, tRNA N3-cytidineprovided by HGNC
    Primary source
    HGNC:HGNC:25755
    See related
    Ensembl:ENSG00000087995 MIM:618902; AllianceGenome:HGNC:25755
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    METTL2
    Summary
    Enables tRNA (cytidine-3-)-methyltransferase activity. Involved in tRNA methylation. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in brain (RPKM 6.2), thyroid (RPKM 6.2) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See METTL2A in Genome Data Viewer
    Location:
    17q23.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (62423897..62453385)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (63293823..63323315)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (60501258..60530746)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene EF-hand calcium binding domain 3 Neighboring gene RNA, U7 small nuclear 52 pseudogene Neighboring gene ribosomal protein S23 pseudogene 7 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:60500991-60501521 Neighboring gene uncharacterized LOC112268200 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60541227-60541728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60541729-60542228 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8805 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8806 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8807 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8808 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:60562255-60562754 Neighboring gene tousled like kinase 2 Neighboring gene MPRA-validated peak2934 silencer Neighboring gene ribosomal protein S10 pseudogene 26

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ12760

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables tRNA (cytidine-3-)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables tRNA (cytidine-3-)-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables tRNA (cytidine-3-)-methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in tRNA metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in tRNA methylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in tRNA modification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    tRNA N(3)-cytidine methyltransferase METTL2A
    Names
    methyltransferase 2A, methylcytidine
    methyltransferase like 2A
    methyltransferase-like protein 2A
    tRNA N(3)-methylcytidine methyltransferase METTL2A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181725.4NP_859076.3  tRNA N(3)-cytidine methyltransferase METTL2A

      See identical proteins and their annotated locations for NP_859076.3

      Status: VALIDATED

      Source sequence(s)
      AC008026, AK022822, BC006985, BP255803, DA027807
      Consensus CDS
      CCDS45752.1
      UniProtKB/Swiss-Prot
      A6NNC4, Q96IZ6, Q9H9G9, Q9NUI8, Q9P0B5
      UniProtKB/TrEMBL
      A0A087WW35
      Related
      ENSP00000309610.6, ENST00000311506.10
      Conserved Domains (1) summary
      pfam13649
      Location:184286
      Methyltransf_25; Methyltransferase domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      62423897..62453385
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      63293823..63323315
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001005372.1: Suppressed sequence

      Description
      NM_001005372.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA (NMD) candidate.