Mitf melanogenesis associated transcription factor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mitfprovided by MGI
Official Full Name: melanogenesis associated transcription factorprovided by MGI
Primary source: MGI:MGI:104554
See related: Ensembl:ENSMUSG00000035158 AllianceGenome:MGI:104554
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Wh; bw; mi; vit; BCC2; Bhlhe32; Gsfbcc2; Vitiligo
Summary: This transcription factor serves at a critical point between extracellular signaling and downstream targets in cell specification in early eye and neural crest development. Mutant alleles have been identified that generate distinct phenotypes. Some of these alleles are being used to model the human diseases Waardenburg syndrome IIa and Tietz syndrome. [provided by RefSeq, Jul 2008]
Expression: Biased expression in placenta adult (RPKM 9.0), heart adult (RPKM 4.3) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 D3; 6 45.05 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (97783966..97998321)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (97807002..98021360)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Novel mechanisms of MITF regulation identified in a mouse suppressor screen.
Title: Novel mechanisms of MITF regulation identified in a mouse suppressor screen.
Mitf regulates gene expression networks implicated in B cell homeostasis, germinal center responses, and tolerance.
Title: Mitf regulates gene expression networks implicated in B cell homeostasis, germinal center responses, and tolerance.
Melanogrit potentiates melanogenesis by escalating cellular tyrosinase activity and MITF levels via pERK inhibition.
Title: Melanogrit potentiates melanogenesis by escalating cellular tyrosinase activity and MITF levels via pERK inhibition.
Ataxia Telangiectasia Mutated Signaling Delays Skin Pigmentation upon UV Exposure by Mediating MITF Function toward DNA Repair Mode.
Title: Ataxia Telangiectasia Mutated Signaling Delays Skin Pigmentation upon UV Exposure by Mediating MITF Function toward DNA Repair Mode.
Progressive Cone-Rod Dystrophy and RPE Dysfunction in Mitf[mi/+] Mice.
Title: Progressive Cone-Rod Dystrophy and RPE Dysfunction in Mitf(mi/+) Mice.
DAPL1 deficiency in mice impairs antioxidant defenses in the RPE and leads to retinal degeneration with AMD-like features.
Title: DAPL1 deficiency in mice impairs antioxidant defenses in the RPE and leads to retinal degeneration with AMD-like features.
Novel role of microphthalmia-associated transcription factor in modulating the differentiation and immunosuppressive functions of myeloid-derived suppressor cells.
Title: Novel role of microphthalmia-associated transcription factor in modulating the differentiation and immunosuppressive functions of myeloid-derived suppressor cells.
Mouse microphthalmia-associated transcription factor (Mitf) mutations affect the structure of the retinal vasculature.
Title: Mouse microphthalmia-associated transcription factor (Mitf) mutations affect the structure of the retinal vasculature.
MicroRNA-183-5p regulates MITF expression in vitiligo skin depigmentation.
Title: MicroRNA-183-5p regulates MITF expression in vitiligo skin depigmentation.
Mitf is required for T cell maturation by regulating dendritic cell homing to the thymus.
Title: Mitf is required for T cell maturation by regulating dendritic cell homing to the thymus.

Submit: New GeneRIF Correction See all GeneRIFs (159)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (8) 1 citation
Endonuclease-mediated (7) 1 citation
Other (1)
Radiation induced (3) 1 citation
Spontaneous (13) 1 citation
Targeted (16) 1 citation
Transgenic (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Mitf (e-PCR), detects polymorphism
- UniSTS:143873

Mitf (e-PCR), detects polymorphism
- UniSTS:468008

NoName (e-PCR)
- UniSTS:484944

AI451023 (e-PCR)
- UniSTS:208004

Mitf (e-PCR), detects polymorphism
- UniSTS:547262

Z23066 (e-PCR)
- UniSTS:125920

UniSTS:496619 (e-PCR)
- UniSTS:496619

Mitf (e-PCR), detects polymorphism
- UniSTS:496619

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables E-box binding	IDA Inferred from Direct Assay more info	PubMed
enables E-box binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	ISA Inferred from Sequence Alignment more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within bone remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within camera-type eye development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of melanocyte apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in melanocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within melanocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within melanocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within osteoclast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pigmentation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription initiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription initiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of RNA biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of osteoclast differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of osteoclast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: microphthalmia-associated transcription factor

Names: black eyed white; microphtalmia-associated transcription factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113198.2 → NP_001106669.1 microphthalmia-associated transcription factor isoform 1

See identical proteins and their annotated locations for NP_001106669.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1, also known as Mitf-A).

Source sequence(s)

AC131676, AC157098, AC158650

Consensus CDS

CCDS51861.1

UniProtKB/Swiss-Prot

A0A0N4SVJ5, O08885, O88203, Q08843, Q08874, Q3U2D2, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9

UniProtKB/TrEMBL

E9PZ28

Related

ENSMUSP00000044938.8, ENSMUST00000043637.14

Conserved Domains (3) summary

cd18926
Location:300 → 403

bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins

pfam11851
Location:397 → 522

DUF3371; Domain of unknown function (DUF3371)

pfam15951
Location:56 → 194

MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
NM_001178049.2 → NP_001171520.1 microphthalmia-associated transcription factor isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3, also known as Mitf-H) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AC157098, AC158650

Consensus CDS

CCDS51862.1

UniProtKB/TrEMBL

E9PZ28

Related

ENSMUSP00000098683.4, ENSMUST00000101123.10

Conserved Domains (3) summary

cd00083
Location:293 → 353

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

pfam11851
Location:381 → 506

DUF3371; Domain of unknown function (DUF3371)

pfam15951
Location:40 → 178

MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
NM_001410051.1 → NP_001396980.1 microphthalmia-associated transcription factor isoform 4

Status: VALIDATED

Source sequence(s)

AC131676, AC157098, AC158650

UniProtKB/TrEMBL

E9PZ28
NM_001410052.1 → NP_001396981.1 microphthalmia-associated transcription factor isoform 5

Status: VALIDATED

Source sequence(s)

AC131676, AC157098, AC158650

UniProtKB/TrEMBL

A0A5H1ZRM6, E9PZ28

Related

ENSMUSP00000145132.2, ENSMUST00000203884.3
NM_001410053.1 → NP_001396982.1 microphthalmia-associated transcription factor isoform 6

Status: VALIDATED

Source sequence(s)

AC157098, AC158650

UniProtKB/TrEMBL

E9PZ28
NM_001410054.1 → NP_001396983.1 microphthalmia-associated transcription factor isoform 7

Status: VALIDATED

Source sequence(s)

AC131676, AC157098, AC158650

UniProtKB/TrEMBL

E9PZ28
NM_001410055.1 → NP_001396984.1 microphthalmia-associated transcription factor isoform 8

Status: VALIDATED

Source sequence(s)

AC131676, AC157098, AC158650

UniProtKB/TrEMBL

E9PZ28
NM_001410056.1 → NP_001396985.1 microphthalmia-associated transcription factor isoform 9

Status: VALIDATED

Source sequence(s)

AC131676, AC157098, AC158650

UniProtKB/TrEMBL

E9PZ28
NM_001410057.1 → NP_001396986.1 microphthalmia-associated transcription factor isoform 10

Status: VALIDATED

Source sequence(s)

AC131676, AC157098, AC158650
NM_001410058.1 → NP_001396987.1 microphthalmia-associated transcription factor isoform 11

Status: VALIDATED

Source sequence(s)

AC131676, AC158650

UniProtKB/TrEMBL

A0A0N4SV79
NM_001410059.1 → NP_001396988.1 microphthalmia-associated transcription factor isoform 12

Status: VALIDATED

Source sequence(s)

AC158650

UniProtKB/TrEMBL

A0A0N4SV79, I6L9I6
NM_008601.4 → NP_032627.1 microphthalmia-associated transcription factor isoform 2

See identical proteins and their annotated locations for NP_032627.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2, also known as Mitf-M) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AC158650

Consensus CDS

CCDS20385.1

UniProtKB/TrEMBL

A0A0N4SV79, Q32MU7

Related

ENSMUSP00000044459.7, ENSMUST00000043628.13

Conserved Domains (3) summary

cd00083
Location:202 → 262

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

pfam11851
Location:290 → 415

DUF3371; Domain of unknown function (DUF3371)

pfam15951
Location:11 → 87

MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

97783966..97998321

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165905.1 → XP_036021798.1 microphthalmia-associated transcription factor isoform X11

Conserved Domains (3) summary

cd18926
Location:164 → 267

bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins

pfam11851
Location:261 → 386

DUF3371; Domain of unknown function (DUF3371)

pfam15951
Location:56 → 118

MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
XM_030255210.2 → XP_030111070.1 microphthalmia-associated transcription factor isoform X3

UniProtKB/TrEMBL

E9PZ28

Conserved Domains (3) summary

pfam11851
Location:390 → 515

DUF3371; Domain of unknown function (DUF3371)

pfam15951
Location:55 → 193

MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

cd18926
Location:293 → 396

bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
XM_030255214.2 → XP_030111074.1 microphthalmia-associated transcription factor isoform X9

UniProtKB/TrEMBL

E9PZ28

Conserved Domains (3) summary

pfam11851
Location:339 → 464

DUF3371; Domain of unknown function (DUF3371)

pfam15951
Location:4 → 142

MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

cd18926
Location:242 → 345

bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
XM_030255213.2 → XP_030111073.1 microphthalmia-associated transcription factor isoform X8

UniProtKB/TrEMBL

E9PZ28

Conserved Domains (3) summary

cd18926
Location:248 → 351

bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins

pfam11851
Location:345 → 470

DUF3371; Domain of unknown function (DUF3371)

pfam15951
Location:4 → 142

MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
XM_006505692.5 → XP_006505755.1 microphthalmia-associated transcription factor isoform X8

See identical proteins and their annotated locations for XP_006505755.1

UniProtKB/TrEMBL

E9PZ28

Conserved Domains (3) summary

cd18926
Location:248 → 351

bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins

pfam11851
Location:345 → 470

DUF3371; Domain of unknown function (DUF3371)

pfam15951
Location:4 → 142

MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
XM_006505691.5 → XP_006505754.1 microphthalmia-associated transcription factor isoform X6

UniProtKB/TrEMBL

E9PZ28

Conserved Domains (3) summary

pfam11851
Location:369 → 494

DUF3371; Domain of unknown function (DUF3371)

pfam15951
Location:28 → 166

MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

cd18926
Location:272 → 375

bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
XM_017321428.3 → XP_017176917.1 microphthalmia-associated transcription factor isoform X7

UniProtKB/TrEMBL

E9PZ28

Conserved Domains (3) summary

pfam11851
Location:368 → 493

DUF3371; Domain of unknown function (DUF3371)

pfam15951
Location:27 → 165

MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

cd18926
Location:271 → 374

bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
XM_006505689.5 → XP_006505752.1 microphthalmia-associated transcription factor isoform X4

UniProtKB/TrEMBL

E9PZ28

Conserved Domains (3) summary

pfam11851
Location:380 → 505

DUF3371; Domain of unknown function (DUF3371)

pfam15951
Location:39 → 177

MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

cd18926
Location:283 → 386

bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
XM_006505694.1 → XP_006505757.1 microphthalmia-associated transcription factor isoform X8

See identical proteins and their annotated locations for XP_006505757.1

UniProtKB/TrEMBL

E9PZ28

Related

ENSMUSP00000108965.2, ENSMUST00000113339.8

Conserved Domains (3) summary

cd18926
Location:248 → 351

bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins

pfam11851
Location:345 → 470

DUF3371; Domain of unknown function (DUF3371)

pfam15951
Location:4 → 142

MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
XM_036165907.1 → XP_036021800.1 microphthalmia-associated transcription factor isoform X12

UniProtKB/TrEMBL

A0A0N4SV79

Conserved Domains (3) summary

cd18926
Location:132 → 235

bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins

pfam11851
Location:229 → 354

DUF3371; Domain of unknown function (DUF3371)

pfam15951
Location:1 → 26

MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
XM_036165906.1 → XP_036021799.1 microphthalmia-associated transcription factor isoform X12

UniProtKB/TrEMBL

A0A0N4SV79

Conserved Domains (3) summary

cd18926
Location:132 → 235

bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins

pfam11851
Location:229 → 354

DUF3371; Domain of unknown function (DUF3371)

pfam15951
Location:1 → 26

MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
XM_006505695.5 → XP_006505758.1 microphthalmia-associated transcription factor isoform X10

UniProtKB/TrEMBL

A0A0N4SV79

Related

ENSMUSP00000144988.2, ENSMUST00000203938.2

Conserved Domains (3) summary

pfam11851
Location:284 → 409

DUF3371; Domain of unknown function (DUF3371)

pfam15951
Location:11 → 87

MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

cd18926
Location:187 → 290

bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins