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    Slc7a1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 [ Mus musculus (house mouse) ]

    Gene ID: 11987, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc7a1provided by MGI
    Official Full Name
    solute carrier family 7 (cationic amino acid transporter, y+ system), member 1provided by MGI
    Primary source
    MGI:MGI:88117
    See related
    Ensembl:ENSMUSG00000041313 AllianceGenome:MGI:88117
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ERR; Cat1; EcoR; Atrc1; CAT-1; Rec-1; Rev-1; Atrc-1; mCAT-1; 4831426K01Rik
    Summary
    Enables L-amino acid transmembrane transporter activity and virus receptor activity. Involved in L-arginine transmembrane transport and L-ornithine transmembrane transport. Predicted to be located in apical plasma membrane and basolateral plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; cranium; genitourinary system; immune system; and jaw. Orthologous to human SLC7A1 (solute carrier family 7 member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 11.4), genital fat pad adult (RPKM 10.4) and 27 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Slc7a1 in Genome Data Viewer
    Location:
    5 G3; 5 88.48 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (148264220..148336714, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (148327410..148399904, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene microtubule associated tumor suppressor candidate 2 Neighboring gene STARR-seq mESC enhancer starr_14894 Neighboring gene predicted gene, 46928 Neighboring gene STARR-seq mESC enhancer starr_14896 Neighboring gene fused in sarcoma pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E675 Neighboring gene STARR-seq mESC enhancer starr_14901 Neighboring gene STARR-positive B cell enhancer mm9_chr5:149263482-149263782 Neighboring gene STARR-seq mESC enhancer starr_14907 Neighboring gene STARR-seq mESC enhancer starr_14908 Neighboring gene ubiquitin-like 3 Neighboring gene predicted gene, 35735

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in L-amino acid transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in L-arginine import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in L-arginine import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within L-arginine transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in L-arginine transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in L-arginine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in L-histidine import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in L-histidine import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in L-lysine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in L-ornithine transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in L-ornithine transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in amino acid import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lysine transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lysine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ornithine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in symbiont entry into host cell IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basal plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IC
    Inferred by Curator
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    high affinity cationic amino acid transporter 1
    Names
    cationic amino acid transporter 1
    ecotropic retroviral leukemia receptor
    ecotropic retrovirus receptor
    solute carrier family 7 member 1
    system Y+ basic amino acid transporter

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301424.2NP_001288353.1  high affinity cationic amino acid transporter 1

      See identical proteins and their annotated locations for NP_001288353.1

      Status: VALIDATED

      Source sequence(s)
      AC109498
      Consensus CDS
      CCDS19882.1
      UniProtKB/Swiss-Prot
      P30824, Q09143
      UniProtKB/TrEMBL
      Q3UGD6, Q3UTL4
      Related
      ENSMUSP00000117781.2, ENSMUST00000138257.8
      Conserved Domains (1) summary
      TIGR00906
      Location:4603
      2A0303; cationic amino acid transport permease
    2. NM_001429137.1NP_001416066.1  high affinity cationic amino acid transporter 1

      Status: VALIDATED

      Source sequence(s)
      AC109498
      UniProtKB/Swiss-Prot
      P30824, Q09143
      UniProtKB/TrEMBL
      Q3UGD6, Q3UTL4
    3. NM_001429138.1NP_001416067.1  high affinity cationic amino acid transporter 1

      Status: VALIDATED

      Source sequence(s)
      AC109498
      UniProtKB/Swiss-Prot
      P30824, Q09143
      UniProtKB/TrEMBL
      Q3UGD6, Q3UTL4
    4. NM_007513.5NP_031539.3  high affinity cationic amino acid transporter 1

      See identical proteins and their annotated locations for NP_031539.3

      Status: VALIDATED

      Source sequence(s)
      AC109498
      Consensus CDS
      CCDS19882.1
      UniProtKB/Swiss-Prot
      P30824, Q09143
      UniProtKB/TrEMBL
      Q3UGD6, Q3UTL4
      Related
      ENSMUSP00000046714.9, ENSMUST00000048116.15
      Conserved Domains (1) summary
      TIGR00906
      Location:4603
      2A0303; cationic amino acid transport permease

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      148264220..148336714 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504796.3XP_006504859.1  high affinity cationic amino acid transporter 1 isoform X1

      Conserved Domains (1) summary
      TIGR00906
      Location:4603
      2A0303; cationic amino acid transport permease