Rnase12 ribonuclease, RNase A family, 12 (non-active) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rnase12provided by MGI
Official Full Name: ribonuclease, RNase A family, 12 (non-active)provided by MGI
Primary source: MGI:MGI:3528588
See related: Ensembl:ENSMUSG00000068407 AllianceGenome:MGI:3528588
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rai1
Summary: Predicted to enable RNA nuclease activity. Predicted to be involved in defense response to Gram-positive bacterium. Predicted to be located in extracellular region. Orthologous to human RNASE12 (ribonuclease A family member 12 (inactive)). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human all
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Genomic context

Location:: 14 C1; 14 26.36 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (51294155..51294699, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (51056698..51057242, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA nuclease activity	IBA Inferred from Biological aspect of Ancestor more info
NOT enables RNA nuclease activity	IKR Inferred from Key Residues more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in defense response to Gram-positive bacterium	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: probable inactive ribonuclease-like protein 12

Names: ribonuclease A i1; ribonuclease-like protein 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001011875.2 → NP_001011875.1 probable inactive ribonuclease-like protein 12 precursor

See identical proteins and their annotated locations for NP_001011875.1

Status: VALIDATED

Source sequence(s)

BC146014

Consensus CDS

CCDS27032.1

UniProtKB/Swiss-Prot

Q5GAM8

UniProtKB/TrEMBL

W0UUY1

Related

ENSMUSP00000087231.3, ENSMUST00000089798.3

Conserved Domains (1) summary

cl00128
Location:25 → 138

RNase_A; RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine pancreatic ribonuclease A (RNase A). Many of these enzymes have special biological activities; for example, some stimulate the development of vascular ...