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    Aamp angio-associated migratory protein [ Mus musculus (house mouse) ]

    Gene ID: 227290, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Aampprovided by MGI
    Official Full Name
    angio-associated migratory proteinprovided by MGI
    Primary source
    MGI:MGI:107809
    See related
    Ensembl:ENSMUSG00000006299 AllianceGenome:MGI:107809
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Aamp-rs
    Summary
    Predicted to be located in cell surface; intercellular bridge; and microtubule cytoskeleton. Predicted to be active in cytosol. Orthologous to human AAMP (angio associated migratory cell protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 243.7), placenta adult (RPKM 83.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Aamp in Genome Data Viewer
    Location:
    1 C3; 1 38.53 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (74318999..74324833, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (74279840..74284738, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1996 Neighboring gene actin related protein 2/3 complex, subunit 2 Neighboring gene STARR-positive B cell enhancer ABC_E175 Neighboring gene G protein-coupled bile acid receptor 1 Neighboring gene predicted gene 28364 Neighboring gene paroxysmal nonkinesiogenic dyskinesia Neighboring gene transmembrane BAX inhibitor motif containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E3281 Neighboring gene STARR-positive B cell enhancer ABC_E4323 Neighboring gene STARR-seq mESC enhancer starr_01333 Neighboring gene ciliogenesis associated TTC17 interacting protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A high-resolution genetic, physical, and comparative gene map of the doublefoot (Dbf) region of mouse chromosome 1 and the region of conserved synteny on human chromosome 2q35. Hayes C, et al. Genomics, 2001 Dec. PMID 11735226
    2. Functional characterization and chromosomal localization of a cloned taurine transporter from human placenta. Ramamoorthy S, et al. Biochem J, 1994 Jun 15. PMID 8010975, Free PMC Article
    3. High-resolution gene expression analysis of the developing mouse kidney defines novel cellular compartments within the nephron progenitor population. Mugford JW, et al. Dev Biol, 2009 Sep 15. PMID 19591821, Free PMC Article
    4. Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Brady KP, et al. Genome Res, 1997 Nov. PMID 9371744, Free PMC Article
    5. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC30660

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    angio-associated migratory cell protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190444.1 → NP_001177373.1  angio-associated migratory cell protein isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC113473
      Consensus CDS
      CCDS56631.1
      UniProtKB/TrEMBL
      J3QN89, Q3U9F0
      Related
      ENSMUSP00000136644.2, ENSMUST00000178235.8
      Conserved Domains (4) summary
      smart00320
      Location:391 → 429
      WD40; WD40 repeats
      COG2319
      Location:91 → 432
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:88 → 388
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:139 → 177
      7WD40; WD40 repeat [structural motif]

    2. NM_146110.3 → NP_666222.2  angio-associated migratory cell protein isoform 2

      See identical proteins and their annotated locations for NP_666222.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AK162750, AV170929, BY101182
      Consensus CDS
      CCDS15043.1
      UniProtKB/TrEMBL
      Q3TJ22, Q3U9F0
      Related
      ENSMUSP00000006462.8, ENSMUST00000006462.14
      Conserved Domains (3) summary
      smart00320
      Location:390 → 428
      WD40; WD40 repeats
      cd00200
      Location:87 → 387
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:138 → 176
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      74318999..74324833 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164458.1 → XP_036020351.1  angio-associated migratory cell protein isoform X1

      UniProtKB/TrEMBL
      Q3TJ22, Q3U9F0
      Conserved Domains (3) summary
      smart00320
      Location:390 → 428
      WD40; WD40 repeats
      cd00200
      Location:87 → 387
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:138 → 176
      7WD40; WD40 repeat [structural motif]

    2. XM_006495958.5 → XP_006496021.1  angio-associated migratory cell protein isoform X3

      UniProtKB/TrEMBL
      Q3U9F0
      Conserved Domains (3) summary
      smart00320
      Location:384 → 422
      WD40; WD40 repeats
      cd00200
      Location:81 → 381
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:132 → 170
      7WD40; WD40 repeat [structural motif]

    3. XM_006495957.5 → XP_006496020.1  angio-associated migratory cell protein isoform X2

      UniProtKB/TrEMBL
      Q3U9F0
      Conserved Domains (3) summary
      smart00320
      Location:385 → 423
      WD40; WD40 repeats
      cd00200
      Location:82 → 382
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:133 → 171
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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