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    Arid3c AT-rich interaction domain 3C [ Mus musculus (house mouse) ]

    Gene ID: 550619, updated on 10-Dec-2024

    Summary

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    Official Symbol
    Arid3cprovided by MGI
    Official Full Name
    AT-rich interaction domain 3Cprovided by MGI
    Primary source
    MGI:MGI:3650624
    See related
    Ensembl:ENSMUSG00000066224 AllianceGenome:MGI:3650624
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    This gene is a member of the ARID (AT-rich interaction domain) family of proteins. The ARID domain is a helix-turn-helix motif-based DNA-binding domain. ARID family members have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Arid3c in Genome Data Viewer
    Location:
    4 A5; 4 22.01 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (41723830..41731226, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (41723831..41731142, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene ribonuclease P/MRP 25 subunit-like Neighboring gene dynactin 3 Neighboring gene STARR-positive B cell enhancer ABC_E2689 Neighboring gene sigma non-opioid intracellular receptor 1 Neighboring gene predicted gene, 42274 Neighboring gene STARR-positive B cell enhancer ABC_E10231 Neighboring gene galactose-1-phosphate uridyl transferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ARID proteins: a diverse family of DNA binding proteins implicated in the control of cell growth, differentiation, and development. Wilsker D, et al. Cell Growth Differ, 2002 Mar. PMID 11959810
    2. Characterization of a new ARID family transcription factor (Brightlike/ARID3C) that co-activates Bright/ARID3A-mediated immunoglobulin gene transcription. Tidwell JA, et al. Mol Immunol, 2011 Oct. PMID 21955986, Free PMC Article
    3. Nomenclature of the ARID family of DNA-binding proteins. Wilsker D, et al. Genomics, 2005 Aug. PMID 15922553
    4. Arid3c identifies an uncharacterized subpopulation of V2 interneurons during embryonic spinal cord development. Renaux E, et al. Front Cell Neurosci, 2024. PMID 39479525, Free PMC Article
    5. ARID proteins come in from the desert. Kortschak RD, et al. Trends Biochem Sci, 2000 Jun. PMID 10838570

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. this report introduces Brightlike as an additional functional member of the family of ARID proteins, which should be considered in regulatory circuits, previously ascribed to be mediated by Bright.[ARID3C]
      Title: Characterization of a new ARID family transcription factor (Brightlike/ARID3C) that co-activates Bright/ARID3A-mediated immunoglobulin gene transcription.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    AT-rich interactive domain-containing protein 3C
    Names
    ARID domain-containing protein 3C
    AT rich interactive domain 3C (BRIGHT-like)
    AT rich interactive domain 3C (Bright like)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017362.3 → NP_001017362.1  AT-rich interactive domain-containing protein 3C isoform 1

      See identical proteins and their annotated locations for NP_001017362.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL807796
      Consensus CDS
      CCDS38719.1
      UniProtKB/Swiss-Prot
      A6PWV5, B2RUN0
      Related
      ENSMUSP00000127678.2, ENSMUST00000171251.8
      Conserved Domains (1) summary
      smart00501
      Location:111 → 202
      BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain

    2. NM_001252622.2 → NP_001239551.1  AT-rich interactive domain-containing protein 3C isoform 2

      See identical proteins and their annotated locations for NP_001239551.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AL807796
      Consensus CDS
      CCDS57266.1
      UniProtKB/TrEMBL
      B7ZP08
      Related
      ENSMUSP00000116411.3, ENSMUST00000150809.3
      Conserved Domains (1) summary
      smart00501
      Location:111 → 202
      BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      41723830..41731226 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250077.2 → XP_011248379.1  AT-rich interactive domain-containing protein 3C isoform X1

      Conserved Domains (2) summary
      PRK12323
      Location:67 → 227
      PRK12323; DNA polymerase III subunit gamma/tau
      cl28902
      Location:1 → 88
      ARID; ARID/BRIGHT DNA binding domain family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6PWV5.2 GenPept UniProtKB/Swiss-Prot:A6PWV5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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