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    NPIPB6 nuclear pore complex interacting protein family member B6 [ Homo sapiens (human) ]

    Gene ID: 728741, updated on 10-Dec-2024

    Summary

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    Official Symbol
    NPIPB6provided by HGNC
    Official Full Name
    nuclear pore complex interacting protein family member B6provided by HGNC
    Primary source
    HGNC:HGNC:37454
    See related
    Ensembl:ENSG00000198156 AllianceGenome:HGNC:37454
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NPIPB
    Expression
    Broad expression in testis (RPKM 11.9), skin (RPKM 4.0) and 22 other tissues See more
    Orthologs
    all
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    Genomic context

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    See NPIPB6 in Genome Data Viewer
    Location:
    16p12.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (28342517..28364780, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (28623033..28645151, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (28353838..28376101, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 35 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28271835-28272335 Neighboring gene Sharpr-MPRA regulatory region 11993 Neighboring gene SH3 domain binding kinase 1 Neighboring gene uncharacterized LOC124903670 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:28303338-28303509 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7307 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28341775-28342274 Neighboring gene MPRA-validated peak2550 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28347523-28348022 Neighboring gene eukaryotic translation initiation factor 3 subunit C like Neighboring gene microRNA 6862-1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:28414989-28415489 Neighboring gene cell division cycle 37 pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer. Vichas A, et al. Nat Commun, 2021 Aug 9. PMID 34373451, Free PMC Article
    2. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. Capalbo L, et al. Nat Commun, 2019 Oct 4. PMID 31586073, Free PMC Article
    3. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    nuclear pore complex-interacting protein family member B6
    Names
    nuclear pore complex-interacting protein B type

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282524.2 → NP_001269453.1  nuclear pore complex-interacting protein family member B6

      See identical proteins and their annotated locations for NP_001269453.1

      Status: VALIDATED

      Source sequence(s)
      AC138894, AC138904
      Consensus CDS
      CCDS61892.1
      UniProtKB/Swiss-Prot
      E9PJ23
      UniProtKB/TrEMBL
      B2RXF8
      Conserved Domains (2) summary
      pfam06409
      Location:48 → 301
      NPIP; Nuclear pore complex interacting protein (NPIP)
      cl17068
      Location:2 → 41
      AFD_class_I; Adenylate forming domain, Class I superfamily

    2. NM_001395275.1 → NP_001382204.1  nuclear pore complex-interacting protein family member B6

      Status: VALIDATED

      Source sequence(s)
      AC138894, AC138904
      Consensus CDS
      CCDS61892.1
      UniProtKB/Swiss-Prot
      E9PJ23
      UniProtKB/TrEMBL
      B2RXF8
      Related
      ENSP00000512020.1, ENST00000695563.1
      Conserved Domains (2) summary
      pfam06409
      Location:48 → 301
      NPIP; Nuclear pore complex interacting protein (NPIP)
      cl17068
      Location:2 → 41
      AFD_class_I; Adenylate forming domain, Class I superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      28342517..28364780 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017023631.3 → XP_016879120.1  nuclear pore complex-interacting protein family member B6 isoform X3

      UniProtKB/TrEMBL
      O75199
      Conserved Domains (1) summary
      pfam06409
      Location:23 → 222
      NPIP; Nuclear pore complex interacting protein (NPIP)

    2. XM_005255741.5 → XP_005255798.1  nuclear pore complex-interacting protein family member B6 isoform X1

      See identical proteins and their annotated locations for XP_005255798.1

      UniProtKB/TrEMBL
      E9PS57, I3L0I5
      Related
      ENSP00000435924.1, ENST00000533640.5
      Conserved Domains (2) summary
      pfam06409
      Location:23 → 221
      NPIP; Nuclear pore complex interacting protein (NPIP)
      pfam10243
      Location:330 → 387
      MIP-T3; Microtubule-binding protein MIP-T3

    3. XM_011545931.3 → XP_011544233.1  nuclear pore complex-interacting protein family member B6 isoform X2

      UniProtKB/TrEMBL
      I3L0I5
      Conserved Domains (1) summary
      pfam06409
      Location:10 → 270
      NPIP; Nuclear pore complex interacting protein (NPIP)

    4. XM_047434574.1 → XP_047290530.1  nuclear pore complex-interacting protein family member B6 isoform X1

      UniProtKB/TrEMBL
      E9PS57, I3L0I5

    5. XM_047434575.1 → XP_047290531.1  nuclear pore complex-interacting protein family member B6 isoform X4

      UniProtKB/TrEMBL
      B2RXF8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      28623033..28645151 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047446688.1 → XP_047302644.1  nuclear pore complex-interacting protein family member B6 isoform X9

      UniProtKB/TrEMBL
      I3L0I5

    2. XM_047446687.1 → XP_047302643.1  nuclear pore complex-interacting protein family member B6 isoform X8

      UniProtKB/TrEMBL
      B2RXF8

    3. XM_047446686.1 → XP_047302642.1  nuclear pore complex-interacting protein family member B6 isoform X7

      UniProtKB/TrEMBL
      B2RXF8

    4. XM_047446683.1 → XP_047302639.1  nuclear pore complex-interacting protein family member B6 isoform X5

      UniProtKB/TrEMBL
      B2RXF8

    5. XM_047446684.1 → XP_047302640.1  nuclear pore complex-interacting protein family member B6 isoform X6

      UniProtKB/TrEMBL
      I3L0I5

    6. XM_047446690.1 → XP_047302646.1  nuclear pore complex-interacting protein family member B6 isoform X1

      UniProtKB/TrEMBL
      I3L0I5

    7. XM_047446685.1 → XP_047302641.1  nuclear pore complex-interacting protein family member B6 isoform X6

      UniProtKB/TrEMBL
      I3L0I5

    8. XM_047446689.1 → XP_047302645.1  nuclear pore complex-interacting protein family member B6 isoform X1

      UniProtKB/TrEMBL
      I3L0I5

    9. XM_047446694.1 → XP_047302650.1  nuclear pore complex-interacting protein family member B6 isoform X12

      UniProtKB/TrEMBL
      O75199

    10. XM_047446692.1 → XP_047302648.1  nuclear pore complex-interacting protein family member B6 isoform X3

      UniProtKB/TrEMBL
      O75199

    11. XM_047446691.1 → XP_047302647.1  nuclear pore complex-interacting protein family member B6 isoform X10

      UniProtKB/TrEMBL
      O75199

    12. XM_047446695.1 → XP_047302651.1  nuclear pore complex-interacting protein family member B6 isoform X13

    13. XM_047446693.1 → XP_047302649.1  nuclear pore complex-interacting protein family member B6 isoform X11

    14. XM_047446696.1 → XP_047302652.1  nuclear pore complex-interacting protein family member B6 isoform X14

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9PJ23.1 GenPept UniProtKB/Swiss-Prot:E9PJ23

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