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    Il22ra1 interleukin 22 receptor, alpha 1 [ Mus musculus (house mouse) ]

    Gene ID: 230828, updated on 9-Dec-2024

    Summary

    Official Symbol
    Il22ra1provided by MGI
    Official Full Name
    interleukin 22 receptor, alpha 1provided by MGI
    Primary source
    MGI:MGI:2663588
    See related
    Ensembl:ENSMUSG00000037157 AllianceGenome:MGI:2663588
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Il22r; IL-22R; 9130219A07Rik
    Summary
    Enables interleukin-20 binding activity and interleukin-22 receptor activity. Involved in negative regulation of inflammatory response. Acts upstream of or within defense response to Gram-negative bacterium. Predicted to be active in plasma membrane. Is expressed in ileum. Orthologous to human IL22RA1 (interleukin 22 receptor subunit alpha 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in small intestine adult (RPKM 29.4), large intestine adult (RPKM 23.2) and 3 other tissues See more
    Orthologs
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    Genomic context

    See Il22ra1 in Genome Data Viewer
    Location:
    4 D3; 4 67.99 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (135455470..135482694)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (135728159..135755383)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene interferon lambda receptor 1 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 5 pseudogene Neighboring gene S-phase kinase-associated protein 1A pseudogene Neighboring gene myomesin family, member 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine receptor activity  
    enables interleukin-20 binding PubMed 
    enables interleukin-22 receptor activity PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane  
    is_active_in plasma membrane PubMed 

    General protein information

    Preferred Names
    interleukin-22 receptor subunit alpha-1
    Names
    IL-22 receptor subunit alpha-1
    IL-22R-alpha-1
    IL-22RA1
    interleukin-22 receptor alpha chain

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178257.2NP_839988.1  interleukin-22 receptor subunit alpha-1 precursor

      See identical proteins and their annotated locations for NP_839988.1

      Status: VALIDATED

      Source sequence(s)
      AK141289, AK162333, AL662911
      Consensus CDS
      CCDS18789.1
      UniProtKB/Swiss-Prot
      B2RU51, Q3URP9, Q80XZ4
      Related
      ENSMUSP00000099605.4, ENSMUST00000102546.4
      Conserved Domains (2) summary
      pfam01108
      Location:26107
      Tissue_fac; Tissue factor
      pfam17037
      Location:287374
      CBP_BcsO; Cellulose biosynthesis protein BcsO

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      135455470..135482694
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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