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    Srpk2 serine/arginine-rich protein specific kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 20817, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Srpk2provided by MGI
    Official Full Name
    serine/arginine-rich protein specific kinase 2provided by MGI
    Primary source
    MGI:MGI:1201408
    See related
    Ensembl:ENSMUSG00000062604 AllianceGenome:MGI:1201408
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Wbp6; mSRPK2
    Summary
    Enables several functions, including 14-3-3 protein binding activity; ATP binding activity; and magnesium ion binding activity. Involved in several processes, including nuclear speck organization; positive regulation of neuron apoptotic process; and spliceosomal complex assembly. Located in cytoplasm and nucleus. Is expressed in central nervous system; neural retina; and olfactory epithelium. Orthologous to human SRPK2 (SRSF protein kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 17.3), frontal lobe adult (RPKM 13.0) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Srpk2 in Genome Data Viewer
    Location:
    5 A3; 5 10.36 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (23708262..23889639, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (23503356..23684642, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene SPATA31 subfamily H member 2 Neighboring gene STARR-seq mESC enhancer starr_12600 Neighboring gene STARR-seq mESC enhancer starr_12601 Neighboring gene STARR-seq mESC enhancer starr_12603 Neighboring gene RIKEN cDNA 5031425E22 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:22892703-22893070 Neighboring gene STARR-seq mESC enhancer starr_12606 Neighboring gene STARR-seq mESC enhancer starr_12607 Neighboring gene STARR-positive B cell enhancer ABC_E528 Neighboring gene STARR-positive B cell enhancer ABC_E1297 Neighboring gene lysine (K)-specific methyltransferase 2E Neighboring gene STARR-seq mESC enhancer starr_12611 Neighboring gene STARR-positive B cell enhancer mm9_chr5:23122338-23122639 Neighboring gene STARR-positive B cell enhancer mm9_chr5:23143262-23143562 Neighboring gene STARR-seq mESC enhancer starr_12614 Neighboring gene STARR-positive B cell enhancer mm9_chr5:23206519-23206819 Neighboring gene expressed sequence AI506816 Neighboring gene predicted gene, 42226 Neighboring gene predicted gene, 50451

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Use of chromosome engineering to model a segmental deletion of chromosome band 7q22 found in myeloid malignancies. Wong JC, et al. Blood, 2010 Jun 3. PMID 20233966, Free PMC Article
    2. Regulation of vascular endothelial growth factor (VEGF) splicing from pro-angiogenic to anti-angiogenic isoforms: a novel therapeutic strategy for angiogenesis. Nowak DG, et al. J Biol Chem, 2010 Feb 19. PMID 19906640, Free PMC Article
    3. Novel SR-protein-specific kinase, SRPK2, disassembles nuclear speckles. Kuroyanagi N, et al. Biochem Biophys Res Commun, 1998 Jan 14. PMID 9446799
    4. The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs). Koizumi J, et al. J Biol Chem, 1999 Apr 16. PMID 10196197
    5. SRPK2 phosphorylates tau and mediates the cognitive defects in Alzheimer's disease. Hong Y, et al. J Neurosci, 2012 Nov 28. PMID 23197718, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SRPK2 may contribute to the formation of hyperphosphorylated tau and the pathogenesis of Alzheimer disease.
      Title: SRPK2 phosphorylates tau and mediates the cognitive defects in Alzheimer's disease.
    2. Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons.
      Title: Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 14-3-3 protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in R-loop processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in R-loop processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in RNA splicing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in angiogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of viral genome replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nuclear speck organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of neuron apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of viral genome replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spliceosomal complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spliceosomal complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spliceosomal complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SRSF protein kinase 2
    Names
    SFRS protein kinase 2
    SR-protein-specific kinase 2
    WW domain binding protein 6
    serine/threonine-protein kinase SRPK2
    NP_001346101.1
    NP_001346102.1
    NP_001346103.1
    NP_001346104.1
    NP_001394425.1
    NP_001394427.1
    NP_001394428.1
    NP_001394429.1
    NP_001394430.1
    NP_001394431.1
    NP_001394432.1
    NP_001394433.1
    NP_001394434.1
    NP_001394435.1
    NP_001394436.1
    NP_001394437.1
    NP_001394438.1
    NP_001394439.1
    NP_001394440.1
    NP_001394441.1
    NP_001394442.1
    NP_001394443.1
    NP_001394444.1
    NP_001394445.1
    NP_001394446.1
    NP_001394447.1
    NP_001394448.1
    NP_001394449.1
    NP_001394450.1
    NP_001394451.1
    NP_001394452.1
    NP_033300.2
    XP_011248053.1
    XP_011248054.1
    XP_011248056.1
    XP_011248057.1
    XP_011248058.1
    XP_011248059.1
    XP_011248061.1
    XP_017176257.1
    XP_017176259.1
    XP_017176261.1
    XP_030110172.1
    XP_030110173.1
    XP_030110174.1
    XP_030110175.1
    XP_030110176.1
    XP_030110177.1
    XP_030110178.1
    XP_030110179.1
    XP_030110182.1
    XP_030110184.1
    XP_030110185.1
    XP_036020848.1
    XP_036020849.1
    XP_036020850.1
    XP_036020851.1
    XP_036020853.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359172.2 → NP_001346101.1  SRSF protein kinase 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC117614, AC122022
      UniProtKB/Swiss-Prot
      O54781, Q8VCD9
      Conserved Domains (2) summary
      cl21453
      Location:77 → 265
      PKc_like; Protein Kinases, catalytic domain
      cl27511
      Location:312 → 392
      Na_Ca_ex; Sodium/calcium exchanger protein

    2. NM_001359173.2 → NP_001346102.1  SRSF protein kinase 2 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC117614, AC122022
      UniProtKB/Swiss-Prot
      O54781, Q8VCD9
      Conserved Domains (2) summary
      cl21453
      Location:77 → 265
      PKc_like; Protein Kinases, catalytic domain
      cl27511
      Location:312 → 392
      Na_Ca_ex; Sodium/calcium exchanger protein

    3. NM_001359174.2 → NP_001346103.1  SRSF protein kinase 2 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variant 3, encodes isoform c.
      Source sequence(s)
      AC117614, AC122022
      Consensus CDS
      CCDS39024.1
      UniProtKB/Swiss-Prot
      O54781, Q8VCD9
      UniProtKB/TrEMBL
      A0A0R4J124
      Conserved Domains (3) summary
      cd14217
      Location:66 → 254
      STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
      cl21453
      Location:500 → 680
      PKc_like; Protein Kinases, catalytic domain
      cl27511
      Location:301 → 381
      Na_Ca_ex; Sodium/calcium exchanger protein

    4. NM_001359175.2 → NP_001346104.1  SRSF protein kinase 2 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC117614, AC122022
      UniProtKB/Swiss-Prot
      O54781, Q8VCD9
      Conserved Domains (2) summary
      TIGR00927
      Location:292 → 372
      2A1904; K+-dependent Na+/Ca+ exchanger
      cl21453
      Location:491 → 671
      PKc_like; Protein Kinases, catalytic domain

    5. NM_001407496.1 → NP_001394425.1  SRSF protein kinase 2 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC117614, AC122022
      UniProtKB/Swiss-Prot
      O54781, Q8VCD9

    6. NM_001407498.1 → NP_001394427.1  SRSF protein kinase 2 isoform g

      Status: VALIDATED

      Source sequence(s)
      AC117614, AC122022
      UniProtKB/Swiss-Prot
      O54781, Q8VCD9

    7. NM_001407499.1 → NP_001394428.1  SRSF protein kinase 2 isoform h

      Status: VALIDATED

      Source sequence(s)
      AC117614, AC122022
      UniProtKB/Swiss-Prot
      O54781, Q8VCD9

    8. NM_001407500.1 → NP_001394429.1  SRSF protein kinase 2 isoform i

      Status: VALIDATED

      Source sequence(s)
      AC117614, AC122022
      UniProtKB/Swiss-Prot
      O54781, Q8VCD9

    9. NM_001407501.1 → NP_001394430.1  SRSF protein kinase 2 isoform j

      Status: VALIDATED

      Source sequence(s)
      AC117614, AC122022
      UniProtKB/Swiss-Prot
      O54781, Q8VCD9

    10. NM_001407502.1 → NP_001394431.1  SRSF protein kinase 2 isoform k

      Status: VALIDATED

      Source sequence(s)
      AC117614, AC122022
      UniProtKB/Swiss-Prot
      O54781, Q8VCD9

    11. NM_001407503.1 → NP_001394432.1  SRSF protein kinase 2 isoform l

      Status: VALIDATED

      Source sequence(s)
      AC117614, AC122022
      UniProtKB/Swiss-Prot
      O54781, Q8VCD9

    12. NM_001407504.1 → NP_001394433.1  SRSF protein kinase 2 isoform m

      Status: VALIDATED

      Source sequence(s)
      AC117614, AC122022
      UniProtKB/Swiss-Prot
      O54781, Q8VCD9

    13. NM_001407505.1 → NP_001394434.1  SRSF protein kinase 2 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC117614, AC122022
      UniProtKB/Swiss-Prot
      O54781, Q8VCD9
      UniProtKB/TrEMBL
      A0A0R4J124

    14. NM_001407506.1 → NP_001394435.1  SRSF protein kinase 2 isoform n

      Status: VALIDATED

      Source sequence(s)
      AC117614, AC122022
      UniProtKB/Swiss-Prot
      O54781, Q8VCD9

    15. NM_001407507.1 → NP_001394436.1  SRSF protein kinase 2 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC117614, AC122022
      UniProtKB/Swiss-Prot
      O54781, Q8VCD9

    16. NM_001407508.1 → NP_001394437.1  SRSF protein kinase 2 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC117614, AC122022
      UniProtKB/Swiss-Prot
      O54781, Q8VCD9

    17. NM_001407509.1 → NP_001394438.1  SRSF protein kinase 2 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC117614, AC122022
      UniProtKB/Swiss-Prot
      O54781, Q8VCD9

    18. NM_001407510.1 → NP_001394439.1  SRSF protein kinase 2 isoform o

      Status: VALIDATED

      Source sequence(s)
      AC117614, AC122022
      UniProtKB/Swiss-Prot
      O54781, Q8VCD9

    19. NM_001407511.1 → NP_001394440.1  SRSF protein kinase 2 isoform p

      Status: VALIDATED

      Source sequence(s)
      AC117614, AC122022
      UniProtKB/Swiss-Prot
      O54781, Q8VCD9

    20. NM_001407512.1 → NP_001394441.1  SRSF protein kinase 2 isoform p

      Status: VALIDATED

      Source sequence(s)
      AC117614, AC122022
      UniProtKB/Swiss-Prot
      O54781, Q8VCD9

    21. NM_001407513.1 → NP_001394442.1  SRSF protein kinase 2 isoform q

      Status: VALIDATED

      Source sequence(s)
      AC117614, AC122022
      UniProtKB/Swiss-Prot
      O54781, Q8VCD9

    22. NM_001407514.1 → NP_001394443.1  SRSF protein kinase 2 isoform r

      Status: VALIDATED

      Source sequence(s)
      AC117614, AC122022
      UniProtKB/Swiss-Prot
      O54781, Q8VCD9

    23. NM_001407515.1 → NP_001394444.1  SRSF protein kinase 2 isoform s

      Status: VALIDATED

      Source sequence(s)
      AC122022

    24. NM_001407516.1 → NP_001394445.1  SRSF protein kinase 2 isoform t

      Status: VALIDATED

      Source sequence(s)
      AC122022

    25. NM_001407517.1 → NP_001394446.1  SRSF protein kinase 2 isoform u

      Status: VALIDATED

      Source sequence(s)
      AC122022

    26. NM_001407518.1 → NP_001394447.1  SRSF protein kinase 2 isoform v

      Status: VALIDATED

      Source sequence(s)
      AC122022

    27. NM_001407519.1 → NP_001394448.1  SRSF protein kinase 2 isoform w

      Status: VALIDATED

      Source sequence(s)
      AC122022

    28. NM_001407520.1 → NP_001394449.1  SRSF protein kinase 2 isoform w

      Status: VALIDATED

      Source sequence(s)
      AC122022

    29. NM_001407521.1 → NP_001394450.1  SRSF protein kinase 2 isoform x

      Status: VALIDATED

      Source sequence(s)
      AC122022

    30. NM_001407522.1 → NP_001394451.1  SRSF protein kinase 2 isoform x

      Status: VALIDATED

      Source sequence(s)
      AC122022

    31. NM_001407523.1 → NP_001394452.1  SRSF protein kinase 2 isoform y

      Status: VALIDATED

      Source sequence(s)
      AC122022
      UniProtKB/TrEMBL
      Q8C9R8, Q8CBI1

    32. NM_009274.3 → NP_033300.2  SRSF protein kinase 2 isoform c

      See identical proteins and their annotated locations for NP_033300.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variant 4, encodes isoform c.
      Source sequence(s)
      AC117614, AC122022
      Consensus CDS
      CCDS39024.1
      UniProtKB/Swiss-Prot
      O54781, Q8VCD9
      UniProtKB/TrEMBL
      A0A0R4J124
      Related
      ENSMUSP00000085734.5, ENSMUST00000088392.9
      Conserved Domains (3) summary
      cd14217
      Location:66 → 254
      STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
      cl21453
      Location:500 → 680
      PKc_like; Protein Kinases, catalytic domain
      cl27511
      Location:301 → 381
      Na_Ca_ex; Sodium/calcium exchanger protein

    RNA

    1. NR_152854.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC117614, AC122022

    2. NR_176373.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC117614, AC122022

    3. NR_176374.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC117614, AC122022

    4. NR_176375.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC117614, AC122022

    5. NR_176376.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC117614, AC122022

    6. NR_176377.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC117614, AC122022

    7. NR_176378.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC117614, AC122022

    8. NR_176379.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC117614, AC122022

    9. NR_176380.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC122022

    10. NR_176381.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC122022

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      23708262..23889639 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249751.4 → XP_011248053.1  SRSF protein kinase 2 isoform X1

      UniProtKB/Swiss-Prot
      O54781, Q8VCD9
      Conserved Domains (3) summary
      cd14217
      Location:103 → 291
      STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
      TIGR00927
      Location:338 → 418
      2A1904; K+-dependent Na+/Ca+ exchanger
      cl21453
      Location:537 → 748
      PKc_like; Protein Kinases, catalytic domain

    2. XM_011249759.4 → XP_011248061.1  SRSF protein kinase 2 isoform X20

      Conserved Domains (2) summary
      TIGR00927
      Location:140 → 220
      2A1904; K+-dependent Na+/Ca+ exchanger
      cl21453
      Location:339 → 550
      PKc_like; Protein Kinases, catalytic domain

    3. XM_011249757.4 → XP_011248059.1  SRSF protein kinase 2 isoform X6

      See identical proteins and their annotated locations for XP_011248059.1

      UniProtKB/Swiss-Prot
      O54781, Q8VCD9
      Conserved Domains (2) summary
      TIGR00927
      Location:301 → 381
      2A1904; K+-dependent Na+/Ca+ exchanger
      cl21453
      Location:66 → 254
      PKc_like; Protein Kinases, catalytic domain

    4. XM_030254317.2 → XP_030110177.1  SRSF protein kinase 2 isoform X6

      UniProtKB/Swiss-Prot
      O54781, Q8VCD9
      Conserved Domains (2) summary
      TIGR00927
      Location:301 → 381
      2A1904; K+-dependent Na+/Ca+ exchanger
      cl21453
      Location:66 → 254
      PKc_like; Protein Kinases, catalytic domain

    5. XM_030254314.2 → XP_030110174.1  SRSF protein kinase 2 isoform X6

      UniProtKB/Swiss-Prot
      O54781, Q8VCD9
      Conserved Domains (2) summary
      TIGR00927
      Location:301 → 381
      2A1904; K+-dependent Na+/Ca+ exchanger
      cl21453
      Location:66 → 254
      PKc_like; Protein Kinases, catalytic domain

    6. XM_030254315.2 → XP_030110175.1  SRSF protein kinase 2 isoform X6

      UniProtKB/Swiss-Prot
      O54781, Q8VCD9
      Conserved Domains (2) summary
      TIGR00927
      Location:301 → 381
      2A1904; K+-dependent Na+/Ca+ exchanger
      cl21453
      Location:66 → 254
      PKc_like; Protein Kinases, catalytic domain

    7. XM_030254316.2 → XP_030110176.1  SRSF protein kinase 2 isoform X6

      UniProtKB/Swiss-Prot
      O54781, Q8VCD9
      Conserved Domains (2) summary
      TIGR00927
      Location:301 → 381
      2A1904; K+-dependent Na+/Ca+ exchanger
      cl21453
      Location:66 → 254
      PKc_like; Protein Kinases, catalytic domain

    8. XM_017320770.3 → XP_017176259.1  SRSF protein kinase 2 isoform X13

      UniProtKB/Swiss-Prot
      O54781, Q8VCD9
      Conserved Domains (2) summary
      TIGR00927
      Location:203 → 283
      2A1904; K+-dependent Na+/Ca+ exchanger
      cl21453
      Location:402 → 613
      PKc_like; Protein Kinases, catalytic domain

    9. XM_030254324.2 → XP_030110184.1  SRSF protein kinase 2 isoform X13

      UniProtKB/Swiss-Prot
      O54781, Q8VCD9
      Conserved Domains (2) summary
      TIGR00927
      Location:203 → 283
      2A1904; K+-dependent Na+/Ca+ exchanger
      cl21453
      Location:402 → 613
      PKc_like; Protein Kinases, catalytic domain

    10. XM_030254322.2 → XP_030110182.1  SRSF protein kinase 2 isoform X13

      UniProtKB/Swiss-Prot
      O54781, Q8VCD9
      Conserved Domains (2) summary
      TIGR00927
      Location:203 → 283
      2A1904; K+-dependent Na+/Ca+ exchanger
      cl21453
      Location:402 → 613
      PKc_like; Protein Kinases, catalytic domain

    11. XM_011249756.3 → XP_011248058.1  SRSF protein kinase 2 isoform X6

      See identical proteins and their annotated locations for XP_011248058.1

      UniProtKB/Swiss-Prot
      O54781, Q8VCD9
      Conserved Domains (2) summary
      TIGR00927
      Location:301 → 381
      2A1904; K+-dependent Na+/Ca+ exchanger
      cl21453
      Location:66 → 254
      PKc_like; Protein Kinases, catalytic domain

    12. XM_011249755.4 → XP_011248057.1  SRSF protein kinase 2 isoform X6

      See identical proteins and their annotated locations for XP_011248057.1

      UniProtKB/Swiss-Prot
      O54781, Q8VCD9
      Conserved Domains (2) summary
      TIGR00927
      Location:301 → 381
      2A1904; K+-dependent Na+/Ca+ exchanger
      cl21453
      Location:66 → 254
      PKc_like; Protein Kinases, catalytic domain

    13. XM_030254313.2 → XP_030110173.1  SRSF protein kinase 2 isoform X6

      UniProtKB/Swiss-Prot
      O54781, Q8VCD9
      Conserved Domains (2) summary
      TIGR00927
      Location:301 → 381
      2A1904; K+-dependent Na+/Ca+ exchanger
      cl21453
      Location:66 → 254
      PKc_like; Protein Kinases, catalytic domain

    14. XM_036164955.1 → XP_036020848.1  SRSF protein kinase 2 isoform X6

      UniProtKB/Swiss-Prot
      O54781, Q8VCD9
      Conserved Domains (2) summary
      TIGR00927
      Location:301 → 381
      2A1904; K+-dependent Na+/Ca+ exchanger
      cl21453
      Location:66 → 254
      PKc_like; Protein Kinases, catalytic domain

    15. XM_030254318.2 → XP_030110178.1  SRSF protein kinase 2 isoform X6

      UniProtKB/Swiss-Prot
      O54781, Q8VCD9
      Conserved Domains (2) summary
      TIGR00927
      Location:301 → 381
      2A1904; K+-dependent Na+/Ca+ exchanger
      cl21453
      Location:66 → 254
      PKc_like; Protein Kinases, catalytic domain

    16. XM_036164957.1 → XP_036020850.1  SRSF protein kinase 2 isoform X9

      UniProtKB/Swiss-Prot
      O54781, Q8VCD9
      Conserved Domains (2) summary
      TIGR00927
      Location:292 → 372
      2A1904; K+-dependent Na+/Ca+ exchanger
      cl21453
      Location:66 → 245
      PKc_like; Protein Kinases, catalytic domain

    17. XM_036164958.1 → XP_036020851.1  SRSF protein kinase 2 isoform X9

      UniProtKB/Swiss-Prot
      O54781, Q8VCD9
      Conserved Domains (2) summary
      TIGR00927
      Location:292 → 372
      2A1904; K+-dependent Na+/Ca+ exchanger
      cl21453
      Location:66 → 245
      PKc_like; Protein Kinases, catalytic domain

    18. XM_017320768.2 → XP_017176257.1  SRSF protein kinase 2 isoform X8

      UniProtKB/Swiss-Prot
      O54781, Q8VCD9
      Conserved Domains (2) summary
      TIGR00927
      Location:329 → 409
      2A1904; K+-dependent Na+/Ca+ exchanger
      cl21453
      Location:103 → 282
      PKc_like; Protein Kinases, catalytic domain

    19. XM_011249752.3 → XP_011248054.1  SRSF protein kinase 2 isoform X2

      UniProtKB/Swiss-Prot
      O54781, Q8VCD9
      Conserved Domains (2) summary
      TIGR00927
      Location:329 → 409
      2A1904; K+-dependent Na+/Ca+ exchanger
      cl21453
      Location:103 → 282
      PKc_like; Protein Kinases, catalytic domain

    20. XM_011249754.3 → XP_011248056.1  SRSF protein kinase 2 isoform X4

      UniProtKB/Swiss-Prot
      O54781, Q8VCD9
      Conserved Domains (3) summary
      cd14217
      Location:103 → 291
      STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
      TIGR00927
      Location:338 → 418
      2A1904; K+-dependent Na+/Ca+ exchanger
      cl21453
      Location:537 → 717
      PKc_like; Protein Kinases, catalytic domain

    21. XM_030254312.1 → XP_030110172.1  SRSF protein kinase 2 isoform X5

      UniProtKB/Swiss-Prot
      O54781, Q8VCD9
      Conserved Domains (2) summary
      TIGR00927
      Location:303 → 383
      2A1904; K+-dependent Na+/Ca+ exchanger
      cl21453
      Location:77 → 256
      PKc_like; Protein Kinases, catalytic domain

    22. XM_030254319.2 → XP_030110179.1  SRSF protein kinase 2 isoform X9

      UniProtKB/Swiss-Prot
      O54781, Q8VCD9
      Conserved Domains (2) summary
      TIGR00927
      Location:292 → 372
      2A1904; K+-dependent Na+/Ca+ exchanger
      cl21453
      Location:66 → 245
      PKc_like; Protein Kinases, catalytic domain

    23. XM_030254325.1 → XP_030110185.1  SRSF protein kinase 2 isoform X14

      UniProtKB/Swiss-Prot
      O54781, Q8VCD9
      Conserved Domains (2) summary
      TIGR00927
      Location:194 → 274
      2A1904; K+-dependent Na+/Ca+ exchanger
      cl21453
      Location:393 → 604
      PKc_like; Protein Kinases, catalytic domain

    24. XM_036164956.1 → XP_036020849.1  SRSF protein kinase 2 isoform X9

      UniProtKB/Swiss-Prot
      O54781, Q8VCD9
      Conserved Domains (2) summary
      TIGR00927
      Location:292 → 372
      2A1904; K+-dependent Na+/Ca+ exchanger
      cl21453
      Location:66 → 245
      PKc_like; Protein Kinases, catalytic domain

    25. XM_036164960.1 → XP_036020853.1  SRSF protein kinase 2 isoform X21

      Conserved Domains (2) summary
      TIGR00927
      Location:131 → 211
      2A1904; K+-dependent Na+/Ca+ exchanger
      cl21453
      Location:330 → 541
      PKc_like; Protein Kinases, catalytic domain

    26. XM_017320772.3 → XP_017176261.1  SRSF protein kinase 2 isoform X19

      Conserved Domains (2) summary
      TIGR00927
      Location:145 → 225
      2A1904; K+-dependent Na+/Ca+ exchanger
      cl21453
      Location:344 → 555
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O54781.2 GenPept UniProtKB/Swiss-Prot:O54781

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