U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Srpx sushi-repeat-containing protein [ Mus musculus (house mouse) ]

    Gene ID: 51795, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Srpxprovided by MGI
    Official Full Name
    sushi-repeat-containing proteinprovided by MGI
    Primary source
    MGI:MGI:1858306
    See related
    Ensembl:ENSMUSG00000090084 AllianceGenome:MGI:1858306
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    drs; DRS-1; DRS-2; drs-1; drs-2
    Summary
    Acts upstream of or within several processes, including negative regulation of cell proliferation involved in contact inhibition; phagolysosome assembly; and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in autophagosome and endoplasmic reticulum. Is expressed in several structures, including otic capsule and skeleton. Orthologous to human SRPX (sushi repeat containing protein X-linked). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in mammary gland adult (RPKM 23.2), bladder adult (RPKM 15.6) and 16 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Srpx in Genome Data Viewer
    Location:
    X A1.1; X 4.62 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (9904216..9983879, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (10037977..10117640, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene synaptotagmin-like 5 Neighboring gene H2A histone family member L3 Neighboring gene STARR-seq mESC enhancer starr_46716 Neighboring gene predicted gene 5754 Neighboring gene STARR-seq mESC enhancer starr_46717 Neighboring gene predicted gene, 33844 Neighboring gene retinitis pigmentosa GTPase regulator

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The drs tumor suppressor regulates glucose metabolism via lactate dehydrogenase-B. Tambe Y, et al. Mol Carcinog, 2016 Jan. PMID 25620379
    2. Suppression of viral replication by drs tumor suppressor via mTOR dependent pathway. Tambe Y, et al. Cancer Lett, 2012 Jan 1. PMID 21983129
    3. Sushi repeat-containing protein 1: a novel disease-associated molecule in cerebral amyloid angiopathy. Inoue Y, et al. Acta Neuropathol, 2017 Oct. PMID 28478503
    4. Tumor prone phenotype of mice deficient in a novel apoptosis-inducing gene, drs. Tambe Y, et al. Carcinogenesis, 2007 Apr. PMID 17088259
    5. Isolation of a novel mouse variant of the drs tumor suppressor gene. Kawai T, et al. Cancer Lett, 2002 Sep 8. PMID 12049817

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SRPX1 co-accumulated with Abeta deposits in cerebral blood vessels of all autopsied cases with severe cerebral amyloid angiopathy (CAA); no SRPX1 co-accumulated with Abeta deposits in senile plaques. Furthermore, we demonstrated that both Abeta40 and Abeta42 bound to SRPX1 in vitro and enhanced SRPX1 expression in primary cultures of cerebrovascular smooth muscle cells. SRPX1 enhanced caspase activity induced by Abeta40.
      Title: Sushi repeat-containing protein 1: a novel disease-associated molecule in cerebral amyloid angiopathy.
    2. drs regulates glucose metabolism via LDH-B. Downregulating drs may contribute to the Warburg effect, which is closely associated with malignant progression of cancer cells.
      Title: The drs tumor suppressor regulates glucose metabolism via lactate dehydrogenase-B.
    3. Drs suppresses viral replication via mTOR-dependent pathway.
      Title: Suppression of viral replication by drs tumor suppressor via mTOR dependent pathway.
    4. drs is involved in the maturation process of autophagy from autophagosomes to autolysosomes
      Title: The drs tumor suppressor is involved in the maturation process of autophagy induced by low serum.
    5. Tumor prone phenotype of mice deficient in a novel apoptosis-inducing gene, drs
      Title: Tumor prone phenotype of mice deficient in a novel apoptosis-inducing gene, drs.
    6. Isolation of a novel variant of the tumor suppressor gene (mDRS-2)
      Title: Isolation of a novel mouse variant of the drs tumor suppressor gene.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    General gene information

    Go to the top of the page Help

    Markers

    Potential readthrough

    Included gene: Rpgr

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of cell proliferation involved in contact inhibition IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phagolysosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phagolysosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in autophagosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    sushi-repeat-containing protein SRPX
    Names
    sushi-repeat-containing protein, X-chromosome

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001365087.1 → NP_001352016.1  sushi-repeat-containing protein SRPX isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      BX005236
      Consensus CDS
      CCDS90696.1
      UniProtKB/TrEMBL
      A2BE45
      Related
      ENSMUSP00000111205.3, ENSMUST00000115543.3
      Conserved Domains (3) summary
      cd00033
      Location:178 → 233
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam02494
      Location:91 → 173
      HYR; HYR domain
      pfam13778
      Location:248 → 367
      DUF4174; Domain of unknown function (DUF4174)

    2. NM_016911.5 → NP_058607.1  sushi-repeat-containing protein SRPX isoform 1 precursor

      See identical proteins and their annotated locations for NP_058607.1

      Status: VALIDATED

      Source sequence(s)
      BX005236
      Consensus CDS
      CCDS30013.1
      UniProtKB/Swiss-Prot
      A2BE46, A2BE47, Q9R0M2, Q9R0M3
      UniProtKB/TrEMBL
      A2BE45
      Related
      ENSMUSP00000047926.4, ENSMUST00000044789.10
      Conserved Domains (3) summary
      cd00033
      Location:262 → 317
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam02494
      Location:175 → 257
      HYR; HYR domain
      pfam13778
      Location:332 → 449
      DUF4174; Domain of unknown function (DUF4174)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      9904216..9983879 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R0M3.1 GenPept UniProtKB/Swiss-Prot:Q9R0M3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools