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    Mrps5 mitochondrial ribosomal protein S5 [ Mus musculus (house mouse) ]

    Gene ID: 77721, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mrps5provided by MGI
    Official Full Name
    mitochondrial ribosomal protein S5provided by MGI
    Primary source
    MGI:MGI:1924971
    See related
    Ensembl:ENSMUSG00000027374 AllianceGenome:MGI:1924971
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1620401I16Rik
    Summary
    Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Located in mitochondrion. Is expressed in several structures, including early conceptus; gonad; heart; liver; and metanephros. Orthologous to human MRPS5 (mitochondrial ribosomal protein S5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 26.9), CNS E18 (RPKM 25.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mrps5 in Genome Data Viewer
    Location:
    2 F1; 2 62.05 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (127429346..127445906)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (127587426..127603986)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 14229 Neighboring gene zinc finger protein 661 Neighboring gene STARR-seq mESC enhancer starr_05627 Neighboring gene STARR-seq mESC enhancer starr_05628 Neighboring gene myelin and lymphocyte protein, T cell differentiation protein Neighboring gene predicted gene, 22889

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phenotype of Mrps5-Associated Phylogenetic Polymorphisms Is Intimately Linked to Mitoribosomal Misreading. Juskeviciene R, et al. Int J Mol Sci, 2022 Apr 15. PMID 35457201, Free PMC Article
    2. Mitonuclear protein imbalance as a conserved longevity mechanism. Houtkooper RH, et al. Nature, 2013 May 23. PMID 23698443, Free PMC Article
    3. A defect in mitochondrial protein translation influences mitonuclear communication in the heart. Gao F, et al. Nat Commun, 2023 Mar 22. PMID 36949106, Free PMC Article
    4. Ribosome. The structure of the human mitochondrial ribosome. Amunts A, et al. Science, 2015 Apr 3. PMID 25838379, Free PMC Article
    5. Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit. Suzuki T, et al. J Biol Chem, 2001 Aug 31. PMID 11402041

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phenotype of Mrps5-Associated Phylogenetic Polymorphisms Is Intimately Linked to Mitoribosomal Misreading.
      Title: Phenotype of Mrps5-Associated Phylogenetic Polymorphisms Is Intimately Linked to Mitoribosomal Misreading.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of mitochondrial small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial small ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial small ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of mitochondrial small ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    small ribosomal subunit protein uS5m
    Names
    28S ribosomal protein S5, mitochondrial
    MRP-S5
    S5mt

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029963.2 → NP_084239.1  small ribosomal subunit protein uS5m

      See identical proteins and their annotated locations for NP_084239.1

      Status: PROVISIONAL

      Source sequence(s)
      AB049941
      Consensus CDS
      CCDS16706.1
      UniProtKB/Swiss-Prot
      Q99N87
      UniProtKB/TrEMBL
      Q3U2U4
      Related
      ENSMUSP00000028852.7, ENSMUST00000028852.13
      Conserved Domains (3) summary
      TIGR01021
      Location:219 → 374
      rpsE_bact; ribosomal protein S5, bacterial/organelle type
      pfam00333
      Location:220 → 285
      Ribosomal_S5; Ribosomal protein S5, N-terminal domain
      pfam03719
      Location:299 → 367
      Ribosomal_S5_C; Ribosomal protein S5, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      127429346..127445906
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99N87.1 GenPept UniProtKB/Swiss-Prot:Q99N87

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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