Sly Sycp3 like Y-linked [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slyprovided by MGI
Official Full Name: Sycp3 like Y-linkedprovided by MGI
Primary source: MGI:MGI:2687328
See related: Ensembl:ENSMUSG00000101155 AllianceGenome:MGI:2687328
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Acts upstream of or within several processes, including sex determination; single fertilization; and spermatid differentiation. Located in cytoplasm and nucleus. Is expressed in brain and testis. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: Y; Y C2

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	Y	NC_000087.8 (57195734..57221886)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	Y	NC_000087.7 (57187206..57213358)

Chromosome Y - NC_000087.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Battle of the Sex Chromosomes: Competition between X and Y Chromosome-Encoded Proteins for Partner Interaction and Chromatin Occupancy Drives Multicopy Gene Expression and Evolution in Muroid Rodents.
Title: Battle of the Sex Chromosomes: Competition between X and Y Chromosome-Encoded Proteins for Partner Interaction and Chromatin Occupancy Drives Multicopy Gene Expression and Evolution in Muroid Rodents.
SLY is a regulator of sperm chromatin remodeling. SMRT/N-CoR repressor complex is involved in gene regulation during sperm differentiation since members of this complex, in particular TBL1XR1, interact with SLY in postmeiotic male germ cells.
Title: SLY regulates genes involved in chromatin remodeling and interacts with TBL1XR1 during sperm differentiation.
deficiency is responsible for the sperm DNA damage/chromatin packaging
Title: Deficiency of the multi-copy mouse Y gene Sly causes sperm DNA damage and abnormal chromatin packaging.
expansion of sex-linked spermatid-expressed genes in mouse is a consequence of the enhancement of postmeiotic sex chromatin repression that accompanies Sly amplification
Title: The multicopy gene Sly represses the sex chromosomes in the male mouse germline after meiosis.
SLY1 interacts with acrosomal protein DKKL1, histone acetyltransferase KAT5 & microtubule-associated protein APPBP2; data suggest SLY1 may be involved in spermiogenesis processes, including control of gene expression & acrosome development or function
Title: The multi-copy mouse gene Sycp3-like Y-linked (Sly) encodes an abundant spermatid protein that interacts with a histone acetyltransferase and an acrosomal protein.

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General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within sex determination	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within single fertilization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within single fertilization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatid differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within spermatid differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Sycp3 like Y-linked

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.