U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    TNS3 tensin 3 [ Homo sapiens (human) ]

    Gene ID: 64759, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    TNS3provided by HGNC
    Official Full Name
    tensin 3provided by HGNC
    Primary source
    HGNC:HGNC:21616
    See related
    Ensembl:ENSG00000136205 MIM:606825; AllianceGenome:HGNC:21616
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TEM6; TENS1
    Summary
    Predicted to enable guanyl-nucleotide exchange factor adaptor activity. Predicted to be involved in positive regulation of guanyl-nucleotide exchange factor activity. Predicted to act upstream of or within several processes, including bone resorption; podosome assembly; and regulation of small GTPase mediated signal transduction. Located in cytosol and focal adhesion. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta (RPKM 15.0), lung (RPKM 14.4) and 25 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See TNS3 in Genome Data Viewer
    Location:
    7p12.3
    Exon count:
    46
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (47275154..47582586, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (47436453..47744868, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (47314752..47622184, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375268 Neighboring gene MPRA-validated peak6510 silencer Neighboring gene serine and arginine rich splicing factor 8C, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:47162015-47162514 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25975 Neighboring gene MPRA-validated peak6511 silencer Neighboring gene uncharacterized LOC124901628 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18166 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25976 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:47332661-47333860 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:47354649-47355451 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:47366159-47366764 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:47383941-47384441 Neighboring gene uncharacterized LOC124901629 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18167 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:47410550-47411140 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr7:47411141-47411732 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr7:47411733-47412323 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:47419203-47420066 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:47440071-47440980 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:47442727-47443235 Neighboring gene NANOG hESC enhancer GRCh37_chr7:47459035-47459536 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:47486948-47487448 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:47510136-47510952 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:47514765-47515308 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr7:47519651-47520334 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:47520335-47521016 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:47521589-47522136 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:47528112-47528658 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:47533187-47533778 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25978 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25979 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:47541736-47542333 Neighboring gene small nucleolar RNA, C/D box 151 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:47542334-47542930 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:47543969-47544469 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:47558749-47559460 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:47559461-47560172 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:47560443-47560949 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:47560950-47561455 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:47576373-47577246 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:47595932-47596660 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:47597389-47598116 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:47621045-47621582 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:47621583-47622120 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25980 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:47650466-47650707 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:47653818-47654364 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:47654365-47654909 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr7:47665579-47666118 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:47674273-47674984 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:47699457-47699997 Neighboring gene long intergenic non-protein coding RNA 1447 Neighboring gene long intergenic non-protein coding RNA 2902

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. CpG dinucleotide-specific hypermethylation of the TNS3 gene promoter in human renal cell carcinoma. Carter JA, et al. Epigenetics, 2013 Jul. PMID 23803643, Free PMC Article
    2. Increased expression levels of tensin3 mRNA in thyroid functional adenomas as compared to non-functioning adenomas. Maeda I, et al. Exp Clin Endocrinol Diabetes, 2009 Apr. PMID 18561090
    3. Abnormal TNS3 gene methylation in patients with congenital scoliosis. Wu Y, et al. BMC Musculoskelet Disord, 2022 Aug 20. PMID 35987623, Free PMC Article
    4. Tensin3 is a novel thyroid-specific gene. Maeda I, et al. J Mol Endocrinol, 2006 Feb. PMID 16461921
    5. Tensin-3 Regulates Integrin-Mediated Proliferation and Differentiation of Tonsil-Derived Mesenchymal Stem Cells. Park GC, et al. Cells, 2019 Dec 30. PMID 31905841, Free PMC Article

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of Tensin-3 as a MALT1 substrate that controls B cell adhesion and lymphoma dissemination.
      Title: Identification of Tensin-3 as a MALT1 substrate that controls B cell adhesion and lymphoma dissemination.
    2. Tensin-3 is involved in osteogenic versus adipogenic fate of human bone marrow stromal cells.
      Title: Tensin-3 is involved in osteogenic versus adipogenic fate of human bone marrow stromal cells.
    3. Abnormal TNS3 gene methylation in patients with congenital scoliosis.
      Title: Abnormal TNS3 gene methylation in patients with congenital scoliosis.
    4. Tensin Regulates Fundamental Biological Processes by Interacting with Integrins of Tonsil-Derived Mesenchymal Stem Cells.
      Title: Tensin Regulates Fundamental Biological Processes by Interacting with Integrins of Tonsil-Derived Mesenchymal Stem Cells.
    5. PEAK1 Y635 phosphorylation regulates cell migration through association with Tensin3 and integrins.
      Title: PEAK1 Y635 phosphorylation regulates cell migration through association with Tensin3 and integrins.
    6. MLL3 suppresses tumorigenesis through regulating TNS3 enhancer activity.
      Title: MLL3 suppresses tumorigenesis through regulating TNS3 enhancer activity.
    7. Tensin-3 Regulates Integrin-Mediated Proliferation and Differentiation of Tonsil-Derived Mesenchymal Stem Cells.
      Title: Tensin-3 Regulates Integrin-Mediated Proliferation and Differentiation of Tonsil-Derived Mesenchymal Stem Cells.
    8. These findings suggested a critical role of MSI1-TNS3 axis in regulating glioblastoma migration.
      Title: Musashi-1 Enhances Glioblastoma Cell Migration and Cytoskeletal Dynamics through Translational Inhibition of Tensin3.
    9. Our work identifies Tns3 as a crucial focal adhesion component regulated by, and functionally contributing to, the switch between adhesive and non-adhesive states in MDA-MB-468 cancer cells.
      Title: A dual phenotype of MDA-MB-468 cancer cells reveals mutual regulation of tensin3 and adhesion plasticity.
    10. A phosphorylation-mediated molecular switch comprising DLC), TNS3, PTEN and PI3K controls the spatiotemporal activation of Rac1 and RhoA, thereby initiating directional cell migration induced by growth factors.
      Title: A phosphorylation switch controls the spatiotemporal activation of Rho GTPases in directional cell migration.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3.
    EBI GWAS Catalog
    A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.
    EBI GWAS Catalog
    Genome-wide diet-gene interaction analyses for risk of colorectal cancer.
    EBI GWAS Catalog

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • FLJ13732, FLJ35545, MGC88434, DKFZp686M1045, DKFZp686K12123

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of Rac protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in focal adhesion HDA PubMed 
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    		  
    located_in podosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    tensin-3
    Names
    tensin-like SH2 domain containing 1
    tensin-like SH2 domain-containing protein 1
    thyroid specific PTB domain protein
    tumor endothelial marker 6

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410877.1 → NP_001397806.1  tensin-3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC073341, AC092000
      Consensus CDS
      CCDS94098.1
      UniProtKB/TrEMBL
      A0A994J537
      Related
      ENSP00000516118.1, ENST00000705350.1

    2. NM_001410878.1 → NP_001397807.1  tensin-3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC073341, AC092000
      Consensus CDS
      CCDS94100.1
      UniProtKB/TrEMBL
      E9PCX8, Q59GW4
      Related
      ENSP00000414358.2, ENST00000457718.6

    3. NM_022748.12 → NP_073585.8  tensin-3 isoform 3

      See identical proteins and their annotated locations for NP_073585.8

      Status: VALIDATED

      Source sequence(s)
      AC073341, AC092000, AF378756, AF417489, AK092864
      Consensus CDS
      CCDS5506.2
      UniProtKB/Swiss-Prot
      B2RNV1, Q68CZ2, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
      UniProtKB/TrEMBL
      Q59GW4
      Related
      ENSP00000312143.9, ENST00000311160.14
      Conserved Domains (5) summary
      cd09927
      Location:1168 → 1284
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      smart00012
      Location:72 → 186
      PTPc_DSPc; Protein tyrosine phosphatase, catalytic domain, undefined specificity
      cd01213
      Location:1308 → 1439
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:173 → 299
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl26464
      Location:624 → 1058
      Atrophin-1; Atrophin-1 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      47275154..47582586 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420733.1 → XP_047276689.1  tensin-3 isoform X9

      UniProtKB/Swiss-Prot
      B2RNV1, Q68CZ2, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
      UniProtKB/TrEMBL
      Q59GW4

    2. XM_047420729.1 → XP_047276685.1  tensin-3 isoform X6

      UniProtKB/TrEMBL
      Q59GW4

    3. XM_047420724.1 → XP_047276680.1  tensin-3 isoform X1

    4. XM_047420731.1 → XP_047276687.1  tensin-3 isoform X9

      UniProtKB/Swiss-Prot
      B2RNV1, Q68CZ2, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
      UniProtKB/TrEMBL
      Q59GW4

    5. XM_047420725.1 → XP_047276681.1  tensin-3 isoform X3

      UniProtKB/TrEMBL
      Q59GW4

    6. XM_047420728.1 → XP_047276684.1  tensin-3 isoform X5

      UniProtKB/TrEMBL
      Q59GW4

    7. XM_047420723.1 → XP_047276679.1  tensin-3 isoform X1

    8. XM_047420730.1 → XP_047276686.1  tensin-3 isoform X9

      UniProtKB/Swiss-Prot
      B2RNV1, Q68CZ2, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
      UniProtKB/TrEMBL
      Q59GW4

    9. XM_047420732.1 → XP_047276688.1  tensin-3 isoform X9

      UniProtKB/Swiss-Prot
      B2RNV1, Q68CZ2, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
      UniProtKB/TrEMBL
      Q59GW4

    10. XM_017012537.2 → XP_016868026.1  tensin-3 isoform X2

      UniProtKB/TrEMBL
      Q59GW4

    11. XM_047420735.1 → XP_047276691.1  tensin-3 isoform X9

      UniProtKB/Swiss-Prot
      B2RNV1, Q68CZ2, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
      UniProtKB/TrEMBL
      Q59GW4

    12. XM_011515480.4 → XP_011513782.1  tensin-3 isoform X9

      See identical proteins and their annotated locations for XP_011513782.1

      UniProtKB/Swiss-Prot
      B2RNV1, Q68CZ2, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
      UniProtKB/TrEMBL
      Q59GW4
      Conserved Domains (5) summary
      cd09927
      Location:1168 → 1284
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      smart00012
      Location:72 → 186
      PTPc_DSPc; Protein tyrosine phosphatase, catalytic domain, undefined specificity
      cd01213
      Location:1308 → 1439
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:173 → 299
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl26464
      Location:624 → 1058
      Atrophin-1; Atrophin-1 family

    13. XM_011515478.3 → XP_011513780.1  tensin-3 isoform X7

      UniProtKB/TrEMBL
      C9JHU5, Q59GW4
      Related
      ENSP00000396914.2, ENST00000450444.6
      Conserved Domains (5) summary
      cd09927
      Location:1257 → 1373
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      smart00404
      Location:161 → 275
      PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
      cd01213
      Location:1397 → 1528
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam00130
      Location:10 → 57
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam10409
      Location:262 → 388
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein

    14. XM_047420726.1 → XP_047276682.1  tensin-3 isoform X4

    15. XM_047420736.1 → XP_047276692.1  tensin-3 isoform X9

      UniProtKB/Swiss-Prot
      B2RNV1, Q68CZ2, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
      UniProtKB/TrEMBL
      Q59GW4

    16. XM_024446876.2 → XP_024302644.1  tensin-3 isoform X9

      UniProtKB/Swiss-Prot
      B2RNV1, Q68CZ2, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
      UniProtKB/TrEMBL
      Q59GW4
      Conserved Domains (5) summary
      cd09927
      Location:1168 → 1284
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      smart00012
      Location:72 → 186
      PTPc_DSPc; Protein tyrosine phosphatase, catalytic domain, undefined specificity
      cd01213
      Location:1308 → 1439
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:173 → 299
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl26464
      Location:624 → 1058
      Atrophin-1; Atrophin-1 family

    17. XM_047420737.1 → XP_047276693.1  tensin-3 isoform X9

      UniProtKB/Swiss-Prot
      B2RNV1, Q68CZ2, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
      UniProtKB/TrEMBL
      Q59GW4

    18. XM_011515481.3 → XP_011513783.1  tensin-3 isoform X9

      See identical proteins and their annotated locations for XP_011513783.1

      UniProtKB/Swiss-Prot
      B2RNV1, Q68CZ2, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
      UniProtKB/TrEMBL
      Q59GW4
      Conserved Domains (5) summary
      cd09927
      Location:1168 → 1284
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      smart00012
      Location:72 → 186
      PTPc_DSPc; Protein tyrosine phosphatase, catalytic domain, undefined specificity
      cd01213
      Location:1308 → 1439
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:173 → 299
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl26464
      Location:624 → 1058
      Atrophin-1; Atrophin-1 family

    19. XM_047420738.1 → XP_047276694.1  tensin-3 isoform X9

      UniProtKB/Swiss-Prot
      B2RNV1, Q68CZ2, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
      UniProtKB/TrEMBL
      Q59GW4

    20. XM_011515479.3 → XP_011513781.1  tensin-3 isoform X8

      Conserved Domains (4) summary
      cd09927
      Location:1211 → 1327
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      smart00404
      Location:115 → 229
      PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
      cd01213
      Location:1351 → 1482
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:216 → 342
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein

    21. XM_011515483.3 → XP_011513785.1  tensin-3 isoform X9

      See identical proteins and their annotated locations for XP_011513785.1

      UniProtKB/Swiss-Prot
      B2RNV1, Q68CZ2, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
      UniProtKB/TrEMBL
      Q59GW4
      Conserved Domains (5) summary
      cd09927
      Location:1168 → 1284
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      smart00012
      Location:72 → 186
      PTPc_DSPc; Protein tyrosine phosphatase, catalytic domain, undefined specificity
      cd01213
      Location:1308 → 1439
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:173 → 299
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl26464
      Location:624 → 1058
      Atrophin-1; Atrophin-1 family

    22. XM_011515484.4 → XP_011513786.1  tensin-3 isoform X10

      UniProtKB/TrEMBL
      A0A994J7F3, Q8NDL6
      Related
      ENSP00000516130.1, ENST00000705474.1
      Conserved Domains (2) summary
      cd09927
      Location:725 → 841
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      cd01213
      Location:865 → 996
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      47436453..47744868 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358825.1 → XP_054214800.1  tensin-3 isoform X6

      UniProtKB/TrEMBL
      Q59GW4

    2. XM_054358830.1 → XP_054214805.1  tensin-3 isoform X9

      UniProtKB/Swiss-Prot
      B2RNV1, Q68CZ2, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
      UniProtKB/TrEMBL
      Q59GW4

    3. XM_054358822.1 → XP_054214797.1  tensin-3 isoform X3

      UniProtKB/TrEMBL
      Q59GW4

    4. XM_054358824.1 → XP_054214799.1  tensin-3 isoform X5

      UniProtKB/TrEMBL
      Q59GW4

    5. XM_054358820.1 → XP_054214795.1  tensin-3 isoform X1

    6. XM_054358828.1 → XP_054214803.1  tensin-3 isoform X9

      UniProtKB/Swiss-Prot
      B2RNV1, Q68CZ2, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
      UniProtKB/TrEMBL
      Q59GW4

    7. XM_054358832.1 → XP_054214807.1  tensin-3 isoform X9

      UniProtKB/Swiss-Prot
      B2RNV1, Q68CZ2, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
      UniProtKB/TrEMBL
      Q59GW4

    8. XM_054358821.1 → XP_054214796.1  tensin-3 isoform X2

      UniProtKB/TrEMBL
      Q59GW4

    9. XM_054358831.1 → XP_054214806.1  tensin-3 isoform X9

      UniProtKB/Swiss-Prot
      B2RNV1, Q68CZ2, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
      UniProtKB/TrEMBL
      Q59GW4

    10. XM_054358826.1 → XP_054214801.1  tensin-3 isoform X7

      UniProtKB/TrEMBL
      Q59GW4

    11. XM_054358823.1 → XP_054214798.1  tensin-3 isoform X4

    12. XM_054358833.1 → XP_054214808.1  tensin-3 isoform X9

      UniProtKB/Swiss-Prot
      B2RNV1, Q68CZ2, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
      UniProtKB/TrEMBL
      Q59GW4

    13. XM_054358829.1 → XP_054214804.1  tensin-3 isoform X9

      UniProtKB/Swiss-Prot
      B2RNV1, Q68CZ2, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
      UniProtKB/TrEMBL
      Q59GW4

    14. XM_054358834.1 → XP_054214809.1  tensin-3 isoform X9

      UniProtKB/Swiss-Prot
      B2RNV1, Q68CZ2, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
      UniProtKB/TrEMBL
      Q59GW4

    15. XM_054358827.1 → XP_054214802.1  tensin-3 isoform X8

    16. XM_054358835.1 → XP_054214810.1  tensin-3 isoform X9

      UniProtKB/Swiss-Prot
      B2RNV1, Q68CZ2, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
      UniProtKB/TrEMBL
      Q59GW4

    17. XM_054358836.1 → XP_054214811.1  tensin-3 isoform X10

      UniProtKB/TrEMBL
      A0A994J7F3, Q8NDL6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68CZ2.2 GenPept UniProtKB/Swiss-Prot:Q68CZ2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous