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    PRR35 proline rich 35 [ Homo sapiens (human) ]

    Gene ID: 146325, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PRR35provided by HGNC
    Official Full Name
    proline rich 35provided by HGNC
    Primary source
    HGNC:HGNC:14139
    See related
    Ensembl:ENSG00000161992 AllianceGenome:HGNC:14139
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C16orf11; LA16c-366D1.2
    Expression
    Restricted expression toward kidney (RPKM 3.0) See more
    Orthologs
    mouse all
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    Genomic context

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    See PRR35 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (559814..565529)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (563204..568946)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (610394..615529)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene calpain 15 Neighboring gene microRNA 5587 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:595817-595984 Neighboring gene microRNA 3176 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:610518-611064 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:611065-611610 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:614644-615540 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:616436-617331 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6919 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6920 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:620915-621809 Neighboring gene NHL repeat containing 4 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class Q Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6921 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:633157-633913 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:633914-634669

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. Khanna R, et al. FEBS J, 2018 Jun. PMID 29676528
    2. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. Choudhury NR, et al. BMC Biol, 2017 Nov 8. PMID 29117863, Free PMC Article
    3. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proline-rich protein 35

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145270.3 → NP_660313.1  proline-rich protein 35

      See identical proteins and their annotated locations for NP_660313.1

      Status: VALIDATED

      Source sequence(s)
      BC016613, Z97986
      Consensus CDS
      CCDS45365.1
      UniProtKB/Swiss-Prot
      P0CG20
      Related
      ENSP00000386499.3, ENST00000409413.4
      Conserved Domains (1) summary
      pfam15269
      Location:17 → 70
      zf-C2H2_7; Zinc-finger

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      559814..565529
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017022959.3 → XP_016878448.1  proline-rich protein 35 isoform X1

      UniProtKB/Swiss-Prot
      P0CG20
      Conserved Domains (1) summary
      pfam15269
      Location:17 → 70
      zf-C2H2_7; Zinc-finger

    2. XM_017022960.3 → XP_016878449.1  proline-rich protein 35 isoform X1

      UniProtKB/Swiss-Prot
      P0CG20
      Conserved Domains (1) summary
      pfam15269
      Location:17 → 70
      zf-C2H2_7; Zinc-finger

    3. XM_017022961.1 → XP_016878450.1  proline-rich protein 35 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      563204..568946
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054379662.1 → XP_054235637.1  proline-rich protein 35 isoform X1

      UniProtKB/Swiss-Prot
      P0CG20

    2. XM_054379663.1 → XP_054235638.1  proline-rich protein 35 isoform X1

      UniProtKB/Swiss-Prot
      P0CG20

    3. XM_054379664.1 → XP_054235639.1  proline-rich protein 35 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CG20.1 GenPept UniProtKB/Swiss-Prot:P0CG20

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