OR8U8 olfactory receptor family 8 subfamily U member 8 [Homo sapiens (human)] - Gene

Summary

Official Symbol: OR8U8provided by HGNC
Official Full Name: olfactory receptor family 8 subfamily U member 8provided by HGNC
Primary source: HGNC:HGNC:27538
See related: AllianceGenome:HGNC:27538
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
Annotation information: Annotation category: only annotated on alternate loci in reference assembly
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Genomic context

Location:: 11q11

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11 (ALT_REF_LOCI_1)	NW_003871073.1 (186374..187333)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11 (PATCHES)	NW_003871073.1 (186374..187333)

NW_003871073.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Variation

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See studies and variants in dbVar

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in detection of chemical stimulus involved in sensory perception of smell	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: olfactory receptor 8U8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013356.2 → NP_001013374.2 olfactory receptor 8U8

Status: VALIDATED

Source sequence(s)

AC208786

UniProtKB/Swiss-Prot

P0C7N1

UniProtKB/TrEMBL

A0A126GW66, A0AAG2T390

Conserved Domains (2) summary

pfam00001
Location:41 → 290

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:31 → 308

7tm_4; Olfactory receptor