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    ZNF197 zinc finger protein 197 [ Homo sapiens (human) ]

    Gene ID: 10168, updated on 10-Dec-2024

    Summary

    Official Symbol
    ZNF197provided by HGNC
    Official Full Name
    zinc finger protein 197provided by HGNC
    Primary source
    HGNC:HGNC:12988
    See related
    Ensembl:ENSG00000186448 MIM:618359; AllianceGenome:HGNC:12988
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P18; VHLaK; ZNF20; ZNF166; ZKSCAN9; ZSCAN41; D3S1363E
    Summary
    This gene product belongs to the zinc finger protein superfamily, members of which are regulatory proteins characterized by nucleic acid-binding zinc finger domains. The encoded protein contains 20 tandemly arrayed C2H2-type zinc fingers, a Kruppel-associated box (KRAB) domain, and a SCAN box. This transcript turns over rapidly and contains 3' UTR AUUUA motifs, which are often a hallmark of rapid turnover. It is overexpressed in some thyroid papillary carcinomas. This gene is located in a cluster of zinc finger genes at 3p21. Naturally-occurring readthrough transcription is observed between this gene and the upstream zinc finger protein 660 gene and is represented by GeneID:110354863. [provided by RefSeq, May 2017]
    Expression
    Ubiquitous expression in thyroid (RPKM 4.1), ovary (RPKM 3.4) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ZNF197 in Genome Data Viewer
    Location:
    3p21.31
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (44625036..44648471)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (44640750..44664179)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (44666528..44689963)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ZKSCAN7 ZNF cluster antisense RNA 1 Neighboring gene ZNF660-ZNF197 readthrough Neighboring gene zinc finger protein 660 Neighboring gene ZNF197 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14270 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:44666861-44667363 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:44689909-44690468 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19768 Neighboring gene zinc finger protein 35 Neighboring gene zinc finger protein 251 pseudogene Neighboring gene zinc finger protein OZF-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14271 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14272 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19769

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Readthrough ZNF660-ZNF197

    Readthrough gene: ZNF660-ZNF197, Included gene: ZNF660

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    zinc finger protein 197
    Names
    VHL-associated KRAB-A domain-containing protein
    pVHL-associated KRAB domain-containing protein
    zinc finger protein 166
    zinc finger protein 20
    zinc finger protein with KRAB and SCAN domains 9

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024855.3NP_001020026.1  zinc finger protein 197 isoform 2

      See identical proteins and their annotated locations for NP_001020026.1

      Status: REVIEWED

      Description
      Transcript Variant: Variants 2 and 4 encode the same isoform (2).
      Source sequence(s)
      AY074878, AY279353
      UniProtKB/Swiss-Prot
      O14709
      Related
      ENSP00000373251.2, ENST00000383745.6
      Conserved Domains (2) summary
      smart00431
      Location:38150
      SCAN; leucine rich region
      pfam01352
      Location:216257
      KRAB; KRAB box
    2. NM_001323293.2NP_001310222.1  zinc finger protein 197 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: Variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      AC099669, BQ002665
      UniProtKB/Swiss-Prot
      B2RAH8, O14709, Q86VG0
      Related
      ENSP00000379370.1, ENST00000396058.1
      Conserved Domains (5) summary
      smart00431
      Location:38150
      SCAN; leucine rich region
      COG5048
      Location:424853
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:400420
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:216256
      KRAB; KRAB box
      pfam13465
      Location:384409
      zf-H2C2_2; Zinc-finger double domain
    3. NM_001323294.2NP_001310223.1  zinc finger protein 197 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: Variants 2 and 4 encode the same isoform (2).
      Source sequence(s)
      AC099669, AY279353, BQ002665
      UniProtKB/Swiss-Prot
      O14709
      Related
      ENSP00000373250.4, ENST00000383744.8
      Conserved Domains (2) summary
      smart00431
      Location:38150
      SCAN; leucine rich region
      pfam01352
      Location:216257
      KRAB; KRAB box
    4. NM_001323295.2NP_001310224.1  zinc finger protein 197 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC099669, BQ002665
      Conserved Domains (6) summary
      smart00349
      Location:1454
      KRAB; krueppel associated box
      COG5048
      Location:221650
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:197217
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:615637
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:1453
      KRAB; KRAB box
      pfam13465
      Location:685710
      zf-H2C2_2; Zinc-finger double domain
    5. NM_001323296.2NP_001310225.1  zinc finger protein 197 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC099669, BQ002665
      Conserved Domains (6) summary
      smart00349
      Location:444
      KRAB; krueppel associated box
      COG5048
      Location:211640
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:187207
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:605627
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:443
      KRAB; KRAB box
      pfam13465
      Location:675700
      zf-H2C2_2; Zinc-finger double domain
    6. NM_006991.5NP_008922.1  zinc finger protein 197 isoform 1

      See identical proteins and their annotated locations for NP_008922.1

      Status: REVIEWED

      Description
      Transcript Variant: Variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      AC099669, AY261677, AY279353, BQ002665
      UniProtKB/Swiss-Prot
      B2RAH8, O14709, Q86VG0
      Related
      ENSP00000345809.4, ENST00000344387.9
      Conserved Domains (5) summary
      smart00431
      Location:38150
      SCAN; leucine rich region
      COG5048
      Location:424853
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:400420
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:216256
      KRAB; KRAB box
      pfam13465
      Location:384409
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. NR_136582.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC099669, AY279353, BC031209

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      44625036..44648471
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_009646197.1 Reference GRCh38.p14 PATCHES

      Range
      150390..173825
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      44640750..44664179
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)