cdc-48.2 Transitional endoplasmic reticulum ATPase homolog 2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cdc-48.2
Official Full Name: Transitional endoplasmic reticulum ATPase homolog 2
Primary source: WormBase:WBGene00008053
Locus tag: CELE_C41C4.8
See related: AllianceGenome:WB:WBGene00008053
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables ATP hydrolysis activity and identical protein binding activity. Involved in several processes, including ERAD pathway; negative regulation of protein localization to centrosome; and protein localization to nucleus. Located in nucleus. Part of VCP-NPL4-UFD1 AAA ATPase complex. Is expressed in body wall musculature; germ line; and intestine. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2Y; Paget's disease of bone; frontotemporal dementia and/or amyotrophic lateral sclerosis 6; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1; and inclusion body myositis. Orthologous to human VCP (valosin containing protein). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cdc-48.2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 5

Sequence:: Chromosome: II; NC_003280.10 (8138496..8141230)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The amount of UBXN-6 was markedly increased upon starvation, but not with the treatment of tunicamycin and rapamycin. The induction upon starvation is a unique characteristic for UBXN-6 among C-terminal cofactors of CDC-48.
Title: Functional characterization of UBXN-6, a C-terminal cofactor of CDC-48, in C. elegans.
ATX-3 interacts with both VCP/p97 worm homologs, CDC-48.1 and CDC-48.2 and the interaction domains were mapped.
Title: ATX-3, CDC-48 and UBXN-5: a new trimolecular complex in Caenorhabditis elegans.
data reveal an essential pathway that regulates reformation of the nucleus after mitosis and defines ubiquitin-dependent protein extraction as a common mechanism of Cdc48/p97 activity also during nucleus formation
Title: Cdc48/p97 promotes reformation of the nucleus by extracting the kinase Aurora B from chromatin.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C41C4.8 (e-PCR)
- UniSTS:309284

C41C4.7 (e-PCR)
- UniSTS:321278

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables polyubiquitin modification-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in ERAD pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in IRE1-mediated unfolded protein response	HEP more info	PubMed
involved_in autophagosome maturation	IBA Inferred from Biological aspect of Ancestor more info
involved_in embryo development ending in birth or egg hatching	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitotic spindle disassembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of protein localization to centrosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in retrograde protein transport, ER to cytosol	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of VCP-NPL4-UFD1 AAA ATPase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of VCP-NPL4-UFD1 AAA ATPase complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Transitional endoplasmic reticulum ATPase homolog 2

NP_495705.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

8138496..8141230

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063304.9 → NP_495705.1 Transitional endoplasmic reticulum ATPase homolog 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495705.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P54812, Q18560

Conserved Domains (5) summary

smart01072
Location:136 → 196

CDC48_2; Cell division protein 48 (CDC48) domain 2

TIGR01243
Location:44 → 773

CDC48; AAA family ATPase, CDC48 subfamily

pfam00004
Location:519 → 652

AAA; ATPase family associated with various cellular activities (AAA)

pfam02359
Location:31 → 112

CDC48_N; Cell division protein 48 (CDC48), N-terminal domain

pfam09336
Location:725 → 769

Vps4_C; Vps4 C terminal oligomerization domain