unc-112 Protein unc-112 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: unc-112
Official Full Name: Protein unc-112
Primary source: WormBase:WBGene00006836
Locus tag: CELE_C47E8.7
See related: AllianceGenome:WB:WBGene00006836
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables integrin binding activity and protein-macromolecule adaptor activity. Involved in several processes, including muscle cell cellular homeostasis; positive regulation of supramolecular fiber organization; and regulation of engulfment of apoptotic cell. Located in cell-substrate junction; contractile muscle fiber; and plasma membrane. Is expressed in body wall musculature; non-striated muscle; and spermatheca. Human ortholog(s) of this gene implicated in Kindler syndrome; leukocyte adhesion deficiency 1; leukocyte adhesion deficiency 3; telangiectasis; and vesiculobullous skin disease. Orthologous to several human genes including FERMT1 (FERM domain containing kindlin 1) and FERMT2 (FERM domain containing kindlin 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See unc-112 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 6

Sequence:: Chromosome: V; NC_003283.11 (14691855..14696654, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

UIG-1, a DH/PH domain containing protein, links a PAT-3/UNC-112 complex to the CDC-42 signaling pathway during muscle formation.
Title: Identification of a novel Cdc42 GEF that is localized to the PAT-3-mediated adhesive structure.
isolation and characterization of PAT-4 missense mutations that permit binding with UNC-112 D382V
Title: Suppressor mutations suggest a surface on PAT-4 (Integrin-linked Kinase) that interacts with UNC-112 (Kindlin).
The following model is proposed. UNC-112 exists in closed inactive and open active conformations, and upon binding of PAT-4 to the UNC-112 N-terminal half, UNC-112 is converted into the open state, able to bind to PAT-3.
Title: A molecular mechanism for the requirement of PAT-4 (integrin-linked kinase (ILK)) for the localization of UNC-112 (Kindlin) to integrin adhesion sites.
RNAi of unc-112 inhibited the overall assembly of actin cytoskeleton in somatic gonad, resulting in oocyte accumulation in the proximal gonad and distal tip cells migration defects.
Title: pat-4/ILK and unc-112/Mig-2 are required for gonad function in Caenorhabditis elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C47E8.7 (e-PCR)
- UniSTS:306490

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	IDA Inferred from Direct Assay more info	PubMed
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of protein localization to organelle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle cell cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle organ development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of myosin II filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of engulfment of apoptotic cell	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in M band	IDA Inferred from Direct Assay more info	PubMed
located_in M band	IEA Inferred from Electronic Annotation more info
is_active_in cell-substrate junction	IBA Inferred from Biological aspect of Ancestor more info
located_in cell-substrate junction	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in striated muscle dense body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Protein unc-112

NP_506628.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

14691855..14696654 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_074227.8 → NP_506628.1 Protein unc-112 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_506628.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q18685

Conserved Domains (5) summary

smart00295
Location:286 → 371

B41; Band 4.1 homologues

cd01237
Location:403 → 528

PH_fermitin; Fermitin family pleckstrin homology (PH) domain

cd13205
Location:608 → 698

FERM_C_fermitin; FERM domain C-lobe of the Fermitin family

pfam00169
Location:411 → 507

PH; PH domain

pfam00373
Location:556 → 614

FERM_M; FERM central domain